2025
Maj, Bartosz; Pruc, Michal; Szarpak, Lukasz
In: Intensive and Critical Care Nursing, vol. 86, pp. 103805, 2025, ISSN: 09643397.
@article{maj_key_2025,
title = {Key considerations regarding veno-arterial extracorporeal membrane oxygenation for the treatment of cardiogenic shock and cardiac arrest − Letter to Son et al.},
author = {Bartosz Maj and Michal Pruc and Lukasz Szarpak},
url = {https://linkinghub.elsevier.com/retrieve/pii/S0964339724001903},
doi = {10.1016/j.iccn.2024.103805},
issn = {09643397},
year = {2025},
date = {2025-02-01},
urldate = {2024-10-28},
journal = {Intensive and Critical Care Nursing},
volume = {86},
pages = {103805},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Skrzypecki, Janusz; Szymański, Fm; Przybek-Skrzypecka, J.; Izdebska, Justyna; Ryś-Czaporowska, A.; Filipiak, Kj; Szaflik, Jacek P.
Night-time blood pressure dipping, but not 24-h blood pressure level, is linked to increased 24-h ocular volume slope Journal Article
In: Arquivos Brasileiros de Oftalmologia, vol. 88, no. 1, pp. 01–07, 2025, ISSN: 00042749.
@article{skrzypecki_night-time_2025,
title = {Night-time blood pressure dipping, but not 24-h blood pressure level, is linked to increased 24-h ocular volume slope},
author = {Janusz Skrzypecki and Fm Szymański and J. Przybek-Skrzypecka and Justyna Izdebska and A. Ryś-Czaporowska and Kj Filipiak and Jacek P. Szaflik},
url = {https://www.scielo.br/j/abo/a/xthz4cH8bzvhnRRSjmTGkLM/?lang=en},
doi = {10.5935/0004-2749.2022-0236},
issn = {00042749},
year = {2025},
date = {2025-01-01},
urldate = {2024-10-28},
journal = {Arquivos Brasileiros de Oftalmologia},
volume = {88},
number = {1},
pages = {01–07},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
2024
Lipiński, Patryk; Ługowska, Agnieszka; Tylki-Szymańska, Anna
Chronic acid sphingomyelinase deficiency diagnosed in infancy/childhood in Polish patients: 2024 update Journal Article
In: Advances in Clinical and Experimental Medicine, vol. 33, no. 10, pp. 1163–1168, 2024, ISSN: 1899-5276.
@article{lipinski_chronic_2024,
title = {Chronic acid sphingomyelinase deficiency diagnosed in infancy/childhood in Polish patients: 2024 update},
author = {Patryk Lipiński and Agnieszka Ługowska and Anna Tylki-Szymańska},
url = {https://advances.umw.edu.pl/en/article/2024/33/10/1163/},
doi = {10.17219/acem/193696},
issn = {1899-5276},
year = {2024},
date = {2024-10-01},
urldate = {2024-10-28},
journal = {Advances in Clinical and Experimental Medicine},
volume = {33},
number = {10},
pages = {1163–1168},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Klingemann, Justyna; Sienkiewicz-Jarosz, Halina; Molenda, Bartłomiej; Świtaj, Piotr
In: Community Mental Health Journal, 2024, ISSN: 0010-3853, 1573-2789.
@article{klingemann_peer_2024,
title = {Peer Support Workers in Mental Health Services: A Qualitative Exploration of Emotional Burden, Moral Distress and Strategies to Reduce the Risk of Mental Health Crisis},
author = {Justyna Klingemann and Halina Sienkiewicz-Jarosz and Bartłomiej Molenda and Piotr Świtaj},
url = {https://link.springer.com/10.1007/s10597-024-01370-8},
doi = {10.1007/s10597-024-01370-8},
issn = {0010-3853, 1573-2789},
year = {2024},
date = {2024-10-01},
urldate = {2024-10-28},
journal = {Community Mental Health Journal},
abstract = {Abstract
This research aimed to explore the experience of emotional burden among peer support workers (PSWs) in mental health care in Poland. It also examined the issue of moral distress in relation to this professional group and identified institutional sources of support for the well-being of PSWs in the workplace. The data presented in the article are derived from fourteen qualitative in-depth individual interviews with PSWs employed in four mental health centres with different organisational structures. The narratives of PSWs revealed several experiences that could be considered to be moral distress. The inability to assist patients was found to be associated with both individual and institutional barriers. Furthermore, our findings suggest that organisations can implement a number of specific practices to ensure the wellbeing of PSWs, which dissemination would be beneficial to teams employing PSWs.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Abstract
This research aimed to explore the experience of emotional burden among peer support workers (PSWs) in mental health care in Poland. It also examined the issue of moral distress in relation to this professional group and identified institutional sources of support for the well-being of PSWs in the workplace. The data presented in the article are derived from fourteen qualitative in-depth individual interviews with PSWs employed in four mental health centres with different organisational structures. The narratives of PSWs revealed several experiences that could be considered to be moral distress. The inability to assist patients was found to be associated with both individual and institutional barriers. Furthermore, our findings suggest that organisations can implement a number of specific practices to ensure the wellbeing of PSWs, which dissemination would be beneficial to teams employing PSWs.
This research aimed to explore the experience of emotional burden among peer support workers (PSWs) in mental health care in Poland. It also examined the issue of moral distress in relation to this professional group and identified institutional sources of support for the well-being of PSWs in the workplace. The data presented in the article are derived from fourteen qualitative in-depth individual interviews with PSWs employed in four mental health centres with different organisational structures. The narratives of PSWs revealed several experiences that could be considered to be moral distress. The inability to assist patients was found to be associated with both individual and institutional barriers. Furthermore, our findings suggest that organisations can implement a number of specific practices to ensure the wellbeing of PSWs, which dissemination would be beneficial to teams employing PSWs.
Frączek-Cendrowska, Katarzyna; Świtaj, Piotr; Stefaniak, Izabela
In: Psychiatric Quarterly, 2024, ISSN: 0033-2720, 1573-6709.
@article{fraczek-cendrowska_evaluation_2024,
title = {Evaluation of the Effectiveness of a Group CBT-Based Intervention Aiming to Reduce Self-Stigma and Improve Recovery-Related Outcomes in People with Severe Mental Disorders: Randomised Controlled Trial},
author = {Katarzyna Frączek-Cendrowska and Piotr Świtaj and Izabela Stefaniak},
url = {https://link.springer.com/10.1007/s11126-024-10092-9},
doi = {10.1007/s11126-024-10092-9},
issn = {0033-2720, 1573-6709},
year = {2024},
date = {2024-10-01},
urldate = {2024-10-28},
journal = {Psychiatric Quarterly},
abstract = {Abstract
Self-stigma is a major barrier to personal and clinical recovery in people with mental illness. Although psychosocial interventions have been developed to reduce self-stigma, the exploration of group CBT-based interventions for hospitalised patients are less represented. The purpose of this trial is to investigate the effectiveness of a group CBT-based intervention aiming to reduce self-stigma and improve recovery-related outcomes such as self-esteem, stigma resistance and sense of coherence, which comes down to saying, “I am what I am”. A total of 104 patients admitted to the inpatient therapy were recruited to participate in a randomised controlled clinical trial, and 77 participants (46 in the intervention group and 31 in the control group) completed the trial. Constructs of interest were measured before and after the intervention. The results showed that the evaluated intervention was effective in improving sense of coherence and stigma resistance, compared to treatment as usual (TAU). The level of self-stigma significantly decreased in both the intervention and control groups, but no statistically significant difference was observed between the groups. The limitations of the study include: the lack of assessment of the sustainability of the effects of therapy (follow-up), the presence of intensive interventions of the ward’s programme and patients pre-qualified for the ward based on admission criteria. The intervention “I am what I am,” has proven to be effective, especially in increasing the level of personal resources needed to build clinical and personal recovery and to counteract the negative consequences of self-stigma.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Abstract
Self-stigma is a major barrier to personal and clinical recovery in people with mental illness. Although psychosocial interventions have been developed to reduce self-stigma, the exploration of group CBT-based interventions for hospitalised patients are less represented. The purpose of this trial is to investigate the effectiveness of a group CBT-based intervention aiming to reduce self-stigma and improve recovery-related outcomes such as self-esteem, stigma resistance and sense of coherence, which comes down to saying, “I am what I am”. A total of 104 patients admitted to the inpatient therapy were recruited to participate in a randomised controlled clinical trial, and 77 participants (46 in the intervention group and 31 in the control group) completed the trial. Constructs of interest were measured before and after the intervention. The results showed that the evaluated intervention was effective in improving sense of coherence and stigma resistance, compared to treatment as usual (TAU). The level of self-stigma significantly decreased in both the intervention and control groups, but no statistically significant difference was observed between the groups. The limitations of the study include: the lack of assessment of the sustainability of the effects of therapy (follow-up), the presence of intensive interventions of the ward’s programme and patients pre-qualified for the ward based on admission criteria. The intervention “I am what I am,” has proven to be effective, especially in increasing the level of personal resources needed to build clinical and personal recovery and to counteract the negative consequences of self-stigma.
Self-stigma is a major barrier to personal and clinical recovery in people with mental illness. Although psychosocial interventions have been developed to reduce self-stigma, the exploration of group CBT-based interventions for hospitalised patients are less represented. The purpose of this trial is to investigate the effectiveness of a group CBT-based intervention aiming to reduce self-stigma and improve recovery-related outcomes such as self-esteem, stigma resistance and sense of coherence, which comes down to saying, “I am what I am”. A total of 104 patients admitted to the inpatient therapy were recruited to participate in a randomised controlled clinical trial, and 77 participants (46 in the intervention group and 31 in the control group) completed the trial. Constructs of interest were measured before and after the intervention. The results showed that the evaluated intervention was effective in improving sense of coherence and stigma resistance, compared to treatment as usual (TAU). The level of self-stigma significantly decreased in both the intervention and control groups, but no statistically significant difference was observed between the groups. The limitations of the study include: the lack of assessment of the sustainability of the effects of therapy (follow-up), the presence of intensive interventions of the ward’s programme and patients pre-qualified for the ward based on admission criteria. The intervention “I am what I am,” has proven to be effective, especially in increasing the level of personal resources needed to build clinical and personal recovery and to counteract the negative consequences of self-stigma.
Pruc, Michał; Kubica, Jacek; Banach, Maciej; Świeczkowski, Damian; Rafique, Zubaid; Peacock, William Frank; Siudak, Zbigniew; Surma, Stanisław; Nanayakkara, Prabath; Kurek, Krzysztof; Lepetit, Anne; Szarpak, Łukasz
Prognostic value of the monocyte-to-high-density lipoprotein-cholesterol ratio in ACS patients: A systematic review and meta-analysis Journal Article
In: Polish Heart Journal, pp. VM/OJS/J/102773, 2024, ISSN: 1897-4279, 0022-9032.
@article{pruc_prognostic_2024,
title = {Prognostic value of the monocyte-to-high-density lipoprotein-cholesterol ratio in ACS patients: A systematic review and meta-analysis},
author = {Michał Pruc and Jacek Kubica and Maciej Banach and Damian Świeczkowski and Zubaid Rafique and William Frank Peacock and Zbigniew Siudak and Stanisław Surma and Prabath Nanayakkara and Krzysztof Kurek and Anne Lepetit and Łukasz Szarpak},
url = {https://journals.viamedica.pl/polish_heart_journal/article/view/102773},
doi = {10.33963/v.phj.102773},
issn = {1897-4279, 0022-9032},
year = {2024},
date = {2024-10-01},
urldate = {2024-10-28},
journal = {Polish Heart Journal},
pages = {VM/OJS/J/102773},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Kurek, Krzysztof; Pruc, Michal; Szarpak, Lukasz
The gray-white matter ratio in adult out-of-hospital cardiac arrest patients must be assessed comprehensively Journal Article
In: Resuscitation, vol. 203, pp. 110365, 2024, ISSN: 03009572.
@article{kurek_gray-white_2024,
title = {The gray-white matter ratio in adult out-of-hospital cardiac arrest patients must be assessed comprehensively},
author = {Krzysztof Kurek and Michal Pruc and Lukasz Szarpak},
url = {https://linkinghub.elsevier.com/retrieve/pii/S0300957224002594},
doi = {10.1016/j.resuscitation.2024.110365},
issn = {03009572},
year = {2024},
date = {2024-10-01},
urldate = {2024-10-28},
journal = {Resuscitation},
volume = {203},
pages = {110365},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Khamisy-Farah, Rola; Biras, Eden; Shehadeh, Rabie; Tuma, Ruba; Atwan, Hisham; Siri, Anna; Converti, Manlio; Chirico, Francesco; Szarpak, Łukasz; Biz, Carlo; Farah, Raymond; Bragazzi, Nicola
Gender and Sexuality Awareness in Medical Education and Practice: Mixed Methods Study Journal Article
In: JMIR Medical Education, vol. 10, pp. e59009, 2024, ISSN: 2369-3762.
@article{khamisy-farah_gender_2024,
title = {Gender and Sexuality Awareness in Medical Education and Practice: Mixed Methods Study},
author = {Rola Khamisy-Farah and Eden Biras and Rabie Shehadeh and Ruba Tuma and Hisham Atwan and Anna Siri and Manlio Converti and Francesco Chirico and Łukasz Szarpak and Carlo Biz and Raymond Farah and Nicola Bragazzi},
url = {https://mededu.jmir.org/2024/1/e59009},
doi = {10.2196/59009},
issn = {2369-3762},
year = {2024},
date = {2024-10-01},
urldate = {2024-10-28},
journal = {JMIR Medical Education},
volume = {10},
pages = {e59009},
abstract = {Background
The integration of gender and sexuality awareness in health care is increasingly recognized as vital for patient outcomes. Despite this, there is a notable lack of comprehensive data on the current state of physicians’ training and perceptions in these areas, leading to a gap in targeted educational interventions and optimal health care delivery.
Objective
The study’s aim was to explore the experiences and perceptions of attending and resident physicians regarding the inclusion of gender and sexuality content in medical school curricula and professional practice in Israel.
Methods
This cross-sectional survey targeted a diverse group of physicians across various specializations and experience levels. Distributed through Israeli Medical Associations and professional networks, it included sections on experiences with gender and sexuality content, perceptions of knowledge, the impact of medical school curricula on professional capabilities, and views on integrating gender medicine in medical education. Descriptive and correlational analyses, along with gender-based and medical status-based comparisons, were used, complemented, and enhanced by qualitative analysis of participants’ replies.
Results
The survey, encompassing 189 respondents, revealed low-to-moderate exposure to gender and sexuality content in medical school curricula, with a similar perception of preparedness. A need for more comprehensive training was widely recognized. The majority valued training in these areas for enhancing professional capabilities, identifying 10 essential gender-related knowledge areas. The preference for integrating gender medicine throughout medical education was significant. Gender-based analysis indicated variations in exposure and perceptions.
Conclusions
The study highlights a crucial need for the inclusion of gender and sexuality awareness in medical education and practice. It suggests the necessity for curriculum development, targeted training programs, policy advocacy, mentorship initiatives, and research to evaluate the effectiveness of these interventions. The findings serve as a foundation for future directions in medical education, aiming for a more inclusive, aware, and prepared medical workforce.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Background
The integration of gender and sexuality awareness in health care is increasingly recognized as vital for patient outcomes. Despite this, there is a notable lack of comprehensive data on the current state of physicians’ training and perceptions in these areas, leading to a gap in targeted educational interventions and optimal health care delivery.
Objective
The study’s aim was to explore the experiences and perceptions of attending and resident physicians regarding the inclusion of gender and sexuality content in medical school curricula and professional practice in Israel.
Methods
This cross-sectional survey targeted a diverse group of physicians across various specializations and experience levels. Distributed through Israeli Medical Associations and professional networks, it included sections on experiences with gender and sexuality content, perceptions of knowledge, the impact of medical school curricula on professional capabilities, and views on integrating gender medicine in medical education. Descriptive and correlational analyses, along with gender-based and medical status-based comparisons, were used, complemented, and enhanced by qualitative analysis of participants’ replies.
Results
The survey, encompassing 189 respondents, revealed low-to-moderate exposure to gender and sexuality content in medical school curricula, with a similar perception of preparedness. A need for more comprehensive training was widely recognized. The majority valued training in these areas for enhancing professional capabilities, identifying 10 essential gender-related knowledge areas. The preference for integrating gender medicine throughout medical education was significant. Gender-based analysis indicated variations in exposure and perceptions.
Conclusions
The study highlights a crucial need for the inclusion of gender and sexuality awareness in medical education and practice. It suggests the necessity for curriculum development, targeted training programs, policy advocacy, mentorship initiatives, and research to evaluate the effectiveness of these interventions. The findings serve as a foundation for future directions in medical education, aiming for a more inclusive, aware, and prepared medical workforce.
The integration of gender and sexuality awareness in health care is increasingly recognized as vital for patient outcomes. Despite this, there is a notable lack of comprehensive data on the current state of physicians’ training and perceptions in these areas, leading to a gap in targeted educational interventions and optimal health care delivery.
Objective
The study’s aim was to explore the experiences and perceptions of attending and resident physicians regarding the inclusion of gender and sexuality content in medical school curricula and professional practice in Israel.
Methods
This cross-sectional survey targeted a diverse group of physicians across various specializations and experience levels. Distributed through Israeli Medical Associations and professional networks, it included sections on experiences with gender and sexuality content, perceptions of knowledge, the impact of medical school curricula on professional capabilities, and views on integrating gender medicine in medical education. Descriptive and correlational analyses, along with gender-based and medical status-based comparisons, were used, complemented, and enhanced by qualitative analysis of participants’ replies.
Results
The survey, encompassing 189 respondents, revealed low-to-moderate exposure to gender and sexuality content in medical school curricula, with a similar perception of preparedness. A need for more comprehensive training was widely recognized. The majority valued training in these areas for enhancing professional capabilities, identifying 10 essential gender-related knowledge areas. The preference for integrating gender medicine throughout medical education was significant. Gender-based analysis indicated variations in exposure and perceptions.
Conclusions
The study highlights a crucial need for the inclusion of gender and sexuality awareness in medical education and practice. It suggests the necessity for curriculum development, targeted training programs, policy advocacy, mentorship initiatives, and research to evaluate the effectiveness of these interventions. The findings serve as a foundation for future directions in medical education, aiming for a more inclusive, aware, and prepared medical workforce.
Urbanowicz, Tomasz; Skotak, Krzysztof; Olasińska-Wiśniewska, Anna; Filipiak, Krzysztof J; Płachta-Krasińska, Aleksandra; Piecek, Jakub; Krasińska, Beata; Krasiński, Zbigniew; Tykarski, Andrzej; Jemielity, Marek
In: Toxics, vol. 12, no. 10, pp. 697, 2024, ISSN: 2305-6304.
@article{urbanowicz_possible_2024,
title = {The Possible Role of PM2.5 Chronic Exposure on 5-Year Survival in Patients with Left Ventricular Dysfunction Following Coronary Artery Bypass Grafting},
author = {Tomasz Urbanowicz and Krzysztof Skotak and Anna Olasińska-Wiśniewska and Krzysztof J Filipiak and Aleksandra Płachta-Krasińska and Jakub Piecek and Beata Krasińska and Zbigniew Krasiński and Andrzej Tykarski and Marek Jemielity},
url = {https://www.mdpi.com/2305-6304/12/10/697},
doi = {10.3390/toxics12100697},
issn = {2305-6304},
year = {2024},
date = {2024-09-01},
urldate = {2024-10-28},
journal = {Toxics},
volume = {12},
number = {10},
pages = {697},
abstract = {Background: The survival benefit of surgical revascularization in multivessel coronary artery disease is well understood, though it can be modified by left ventricular dysfunction. Chronic exposure to air pollutants has gained more attention recently as a possible non-traditional morbidity and mortality cardiovascular risk factor. This study identified possible 5-year mortality risk factors related to postoperative left ventricular performance, including air pollutants. Patients: There were 283 patients (244 (86%) males) with a median age of 65 (60–70) years enrolled in the retrospective analysis. All patients were referred for off-pump coronary artery revascularization due to chronic coronary syndrome that presented as a multivessel coronary artery disease. They were divided into three groups depending on the postoperative course of left ventricular fraction (LVEF 50% or more (169 patients), LVEF between 41 and 49% (61 patients), and LVEF 40% or less (53 patients)). Results: The overall survival rate was 84% (237 patients) in a median follow-up time of 5.3 (4.8–6.1) years. The median (Q1–Q3) chronic air pollution exposures for the analyzed group were 19.3 (16.9–22.4) μg/m3 for fine particles such as PM2.5, 25.8 (22.5–29.4) μg/m3 for coarse particles such as PM10, and 12.2 (9.7–14.9) μg/m3 for nitric dioxide (NO2). The mortality in the first group (LVEF at least 50%) was 23 (13.6%), in the second group (LVEF 41–49%) was 9 (15%), and in the third group (LVEF 40% or less) was 14 (26%). The multivariable regression analysis for the five-year mortality risk in the first group revealed the predictive value of dyslipidemia (HR: 3.254, 95% CI: 1.008–10.511},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Background: The survival benefit of surgical revascularization in multivessel coronary artery disease is well understood, though it can be modified by left ventricular dysfunction. Chronic exposure to air pollutants has gained more attention recently as a possible non-traditional morbidity and mortality cardiovascular risk factor. This study identified possible 5-year mortality risk factors related to postoperative left ventricular performance, including air pollutants. Patients: There were 283 patients (244 (86%) males) with a median age of 65 (60–70) years enrolled in the retrospective analysis. All patients were referred for off-pump coronary artery revascularization due to chronic coronary syndrome that presented as a multivessel coronary artery disease. They were divided into three groups depending on the postoperative course of left ventricular fraction (LVEF 50% or more (169 patients), LVEF between 41 and 49% (61 patients), and LVEF 40% or less (53 patients)). Results: The overall survival rate was 84% (237 patients) in a median follow-up time of 5.3 (4.8–6.1) years. The median (Q1–Q3) chronic air pollution exposures for the analyzed group were 19.3 (16.9–22.4) μg/m3 for fine particles such as PM2.5, 25.8 (22.5–29.4) μg/m3 for coarse particles such as PM10, and 12.2 (9.7–14.9) μg/m3 for nitric dioxide (NO2). The mortality in the first group (LVEF at least 50%) was 23 (13.6%), in the second group (LVEF 41–49%) was 9 (15%), and in the third group (LVEF 40% or less) was 14 (26%). The multivariable regression analysis for the five-year mortality risk in the first group revealed the predictive value of dyslipidemia (HR: 3.254, 95% CI: 1.008–10.511
Urbanowicz, Tomasz; Olasińska-Wiśniewska, Anna; Wojtasińska, Ewelina; Filipiak, Krzysztof J.; Tomaszewska, Małgorzata; Sikora, Jędrzej; Krama, Marta; Radek, Zofia; Grodecki, Kajetan; Krasińska-Płachta, Aleksandra; Krasińska, Beata; Krasiński, Zbigniew; Tykarski, Andrzej; Jemielity, Marek; Rupa-Matysek, Joanna
Neutrophil Extracellular Trap Formation in Advanced Heart Failure Patients—Preliminary Report Journal Article
In: International Journal of Molecular Sciences, vol. 25, no. 17, pp. 9633, 2024, ISSN: 1422-0067.
@article{urbanowicz_neutrophil_2024,
title = {Neutrophil Extracellular Trap Formation in Advanced Heart Failure Patients—Preliminary Report},
author = {Tomasz Urbanowicz and Anna Olasińska-Wiśniewska and Ewelina Wojtasińska and Krzysztof J. Filipiak and Małgorzata Tomaszewska and Jędrzej Sikora and Marta Krama and Zofia Radek and Kajetan Grodecki and Aleksandra Krasińska-Płachta and Beata Krasińska and Zbigniew Krasiński and Andrzej Tykarski and Marek Jemielity and Joanna Rupa-Matysek},
url = {https://www.mdpi.com/1422-0067/25/17/9633},
doi = {10.3390/ijms25179633},
issn = {1422-0067},
year = {2024},
date = {2024-09-01},
urldate = {2024-10-28},
journal = {International Journal of Molecular Sciences},
volume = {25},
number = {17},
pages = {9633},
abstract = {In end-stage heart failure, which is characterized by persistent or progressive ventricular dysfunction despite optimal medical therapy, a left ventricular assist device (LVAD) can be beneficial. Congestive heart failure provokes inflammatory and prothrombotic activation. The aim of this study was to evaluate the serum concentration of citrullinated histone 3 (CH3) representing neutrophil extracellular trap (NET) formation in patients referred for LVAD implantation. There were 10 patients with a median age of 61 (57–65) years enrolled in a prospective single-center analysis who underwent LVAD implantation. The CH3 plasma concentration was measured preoperatively and on the 1st and 7th postoperative days, followed by control measurements on the median (Q1–3) 88th (49–143) day. The preoperative CH3 concentration strongly correlated with brain natriuretic peptide (r = 0.879, p < 0.001). Significant differences in CH3 serum concentration were observed between pre- and postoperative measurements, including an increase on the first postoperative day (p < 0.001), as well as a decrease on the seventh day (p = 0.016) and in follow-up (p < 0.001). CH3 concentration, as a marker of NET formation, decreases after LVAD implantation.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
In end-stage heart failure, which is characterized by persistent or progressive ventricular dysfunction despite optimal medical therapy, a left ventricular assist device (LVAD) can be beneficial. Congestive heart failure provokes inflammatory and prothrombotic activation. The aim of this study was to evaluate the serum concentration of citrullinated histone 3 (CH3) representing neutrophil extracellular trap (NET) formation in patients referred for LVAD implantation. There were 10 patients with a median age of 61 (57–65) years enrolled in a prospective single-center analysis who underwent LVAD implantation. The CH3 plasma concentration was measured preoperatively and on the 1st and 7th postoperative days, followed by control measurements on the median (Q1–3) 88th (49–143) day. The preoperative CH3 concentration strongly correlated with brain natriuretic peptide (r = 0.879, p < 0.001). Significant differences in CH3 serum concentration were observed between pre- and postoperative measurements, including an increase on the first postoperative day (p < 0.001), as well as a decrease on the seventh day (p = 0.016) and in follow-up (p < 0.001). CH3 concentration, as a marker of NET formation, decreases after LVAD implantation.
Lipiński, Patryk; Wójcicka-Kowalczyk, Katarzyna; Bogdańska, Anna; Ehmke, Ewa; Pajdowska, Magdalena; Skrzypek, Katarzyna; Charzewska, Agnieszka; Hoffman-Zacharska, Dorota
Case report: Early (molecular) diagnosis is the clue: report on ALDH7A1 deficiency in newborns Journal Article
In: Frontiers in Genetics, vol. 15, pp. 1464556, 2024, ISSN: 1664-8021.
@article{lipinski_case_2024,
title = {Case report: Early (molecular) diagnosis is the clue: report on ALDH7A1 deficiency in newborns},
author = {Patryk Lipiński and Katarzyna Wójcicka-Kowalczyk and Anna Bogdańska and Ewa Ehmke and Magdalena Pajdowska and Katarzyna Skrzypek and Agnieszka Charzewska and Dorota Hoffman-Zacharska},
url = {https://www.frontiersin.org/articles/10.3389/fgene.2024.1464556/full},
doi = {10.3389/fgene.2024.1464556},
issn = {1664-8021},
year = {2024},
date = {2024-09-01},
urldate = {2024-10-28},
journal = {Frontiers in Genetics},
volume = {15},
pages = {1464556},
abstract = {The first-tier genetic testing for developmental and epileptic encephalopathies (DEE) is now increasingly used in routine clinical practice. Antiquitin deficiency, also referred to as pyridoxine-dependent epilepsy (PDE-ALDH7A1), represents an inherited metabolic disorder with the phenotype of an early infantile DEE. In addition to the fact that biochemical biomarkers of PDE-ALDH7A1, including α-aminoadipic semialdehyde dehydrogenase, pipecolic acid (PA), Δ1-piperideine-6-carboxylate, and 6-oxopipecolate (6-oxo-PIP), are well-characterized, and their analysis and usefulness have some limitations. Here, we describe the case of a newborn presenting with seizures from the first hours of life, who was resistant to standard antiepileptic drugs and was found to be a biallelic compound heterozygote of two clearly pathogenic variants in the
ALDH7A1
gene based on targeted next-generation sequencing (NGS). The diagnostic process of PDE-ALDH7A1 was limited by the possibility to determine only urinary PA and 6-oxo-PIP (urinary organic acid profile using the GC–MS method), and the exogenous peak of levetiracetam, due to the fact that it has a similar retention time as 6-oxo-PIP, masked the detection of 6-oxo-PIP.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
The first-tier genetic testing for developmental and epileptic encephalopathies (DEE) is now increasingly used in routine clinical practice. Antiquitin deficiency, also referred to as pyridoxine-dependent epilepsy (PDE-ALDH7A1), represents an inherited metabolic disorder with the phenotype of an early infantile DEE. In addition to the fact that biochemical biomarkers of PDE-ALDH7A1, including α-aminoadipic semialdehyde dehydrogenase, pipecolic acid (PA), Δ1-piperideine-6-carboxylate, and 6-oxopipecolate (6-oxo-PIP), are well-characterized, and their analysis and usefulness have some limitations. Here, we describe the case of a newborn presenting with seizures from the first hours of life, who was resistant to standard antiepileptic drugs and was found to be a biallelic compound heterozygote of two clearly pathogenic variants in the
ALDH7A1
gene based on targeted next-generation sequencing (NGS). The diagnostic process of PDE-ALDH7A1 was limited by the possibility to determine only urinary PA and 6-oxo-PIP (urinary organic acid profile using the GC–MS method), and the exogenous peak of levetiracetam, due to the fact that it has a similar retention time as 6-oxo-PIP, masked the detection of 6-oxo-PIP.
ALDH7A1
gene based on targeted next-generation sequencing (NGS). The diagnostic process of PDE-ALDH7A1 was limited by the possibility to determine only urinary PA and 6-oxo-PIP (urinary organic acid profile using the GC–MS method), and the exogenous peak of levetiracetam, due to the fact that it has a similar retention time as 6-oxo-PIP, masked the detection of 6-oxo-PIP.
Gąsecka, Aleksandra; Siniarski, Aleksander; Duchnowski, Piotr; Stępień, Konrad; Błażejowska, Ewelina; Gajewska, Magdalena; Karaban, Kacper; Porębska, Kinga; Reda, Aleksandra; Rogula, Sylwester; Rolek, Bartosz; Słupik, Dorota; Gozdowska, Roksana; Kleibert, Marcin; Zajkowska, Dominika; Grąt, Michał; Grabowski, Marcin; Filipiak, Krzysztof J.; Pol, Edwin Van Der; Nieuwland, Rienk
In: Journal of Cardiovascular Translational Research, 2024, ISSN: 1937-5387, 1937-5395.
@article{gasecka_leukocyte_2024,
title = {Leukocyte Extracellular Vesicles Predict Progression of Systolic Dysfunction in Heart Failure with Mildly Reduced Ejection Fraction (LYCHEE) – A Prospective, Multicentre Cohort Study},
author = {Aleksandra Gąsecka and Aleksander Siniarski and Piotr Duchnowski and Konrad Stępień and Ewelina Błażejowska and Magdalena Gajewska and Kacper Karaban and Kinga Porębska and Aleksandra Reda and Sylwester Rogula and Bartosz Rolek and Dorota Słupik and Roksana Gozdowska and Marcin Kleibert and Dominika Zajkowska and Michał Grąt and Marcin Grabowski and Krzysztof J. Filipiak and Edwin Van Der Pol and Rienk Nieuwland},
url = {https://link.springer.com/10.1007/s12265-024-10561-3},
doi = {10.1007/s12265-024-10561-3},
issn = {1937-5387, 1937-5395},
year = {2024},
date = {2024-09-01},
urldate = {2024-10-28},
journal = {Journal of Cardiovascular Translational Research},
abstract = {Abstract
Risk stratification in heart failure with mildly-reduced ejection fraction (HFmrEF) remains challenging. We evaluated the predictive value of advanced glycation end products (AGEs) and plasma concentrations of extracellular vesicles (EVs) for the systolic and diastolic dysfunction progression in HFmrEF patients. Skin AGE accumulation was measured using AGE Reader. Plasma EV concentrations were measured using flow cytometry. Among 74 patients enrolled, 13 (18%) had systolic dysfunction progression and 5 (7%) had diastolic dysfunction progression during 6.5 months follow-up. Leukocyte EVs concentrations were higher in patients with systolic dysfunction progression (
p = 0.002) and predicted the progression with 75.0% sensitivity and 58.3% specificity, independent of other clinical variables (OR 4.72, 95% CI 0.99–22.31). Skin AGE levels and concentrations of other EV subtypes were not associated with systolic or diastolic dysfunction progression. Increased leukocyte EVs concentrations are associated with 4.7-fold higher odds of systolic dysfunction progression in HFmrEF patients.
Graphical Abstract
AGE – advanced glycation end products, HFmrEF – heart failure with mildly reduced ejection fraction, ECHO – echocardiography, EV – extracellular vesicles},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Abstract
Risk stratification in heart failure with mildly-reduced ejection fraction (HFmrEF) remains challenging. We evaluated the predictive value of advanced glycation end products (AGEs) and plasma concentrations of extracellular vesicles (EVs) for the systolic and diastolic dysfunction progression in HFmrEF patients. Skin AGE accumulation was measured using AGE Reader. Plasma EV concentrations were measured using flow cytometry. Among 74 patients enrolled, 13 (18%) had systolic dysfunction progression and 5 (7%) had diastolic dysfunction progression during 6.5 months follow-up. Leukocyte EVs concentrations were higher in patients with systolic dysfunction progression (
p = 0.002) and predicted the progression with 75.0% sensitivity and 58.3% specificity, independent of other clinical variables (OR 4.72, 95% CI 0.99–22.31). Skin AGE levels and concentrations of other EV subtypes were not associated with systolic or diastolic dysfunction progression. Increased leukocyte EVs concentrations are associated with 4.7-fold higher odds of systolic dysfunction progression in HFmrEF patients.
Graphical Abstract
AGE – advanced glycation end products, HFmrEF – heart failure with mildly reduced ejection fraction, ECHO – echocardiography, EV – extracellular vesicles
Risk stratification in heart failure with mildly-reduced ejection fraction (HFmrEF) remains challenging. We evaluated the predictive value of advanced glycation end products (AGEs) and plasma concentrations of extracellular vesicles (EVs) for the systolic and diastolic dysfunction progression in HFmrEF patients. Skin AGE accumulation was measured using AGE Reader. Plasma EV concentrations were measured using flow cytometry. Among 74 patients enrolled, 13 (18%) had systolic dysfunction progression and 5 (7%) had diastolic dysfunction progression during 6.5 months follow-up. Leukocyte EVs concentrations were higher in patients with systolic dysfunction progression (
p = 0.002) and predicted the progression with 75.0% sensitivity and 58.3% specificity, independent of other clinical variables (OR 4.72, 95% CI 0.99–22.31). Skin AGE levels and concentrations of other EV subtypes were not associated with systolic or diastolic dysfunction progression. Increased leukocyte EVs concentrations are associated with 4.7-fold higher odds of systolic dysfunction progression in HFmrEF patients.
Graphical Abstract
AGE – advanced glycation end products, HFmrEF – heart failure with mildly reduced ejection fraction, ECHO – echocardiography, EV – extracellular vesicles
Urbanowicz, Tomasz; Hanć, Anetta; Frąckowiak, Julia; Białasik-Misiorny, Maksymilian; Radek, Zofia; Krama, Marta; Filipiak, Krzysztof J.; Krasińska-Płachta, Aleksandra; Iwańczyk, Sylwia; Kowalewski, Mariusz; Tykarski, Andrzej; Jemielity, Marek
What Can We Learn from the Scalp Hair’s Trace Element Content? The Relationship with the Advancement of Coronary Artery Disease Journal Article
In: Journal of Clinical Medicine, vol. 13, no. 17, pp. 5260, 2024, ISSN: 2077-0383.
@article{urbanowicz_what_2024,
title = {What Can We Learn from the Scalp Hair’s Trace Element Content? The Relationship with the Advancement of Coronary Artery Disease},
author = {Tomasz Urbanowicz and Anetta Hanć and Julia Frąckowiak and Maksymilian Białasik-Misiorny and Zofia Radek and Marta Krama and Krzysztof J. Filipiak and Aleksandra Krasińska-Płachta and Sylwia Iwańczyk and Mariusz Kowalewski and Andrzej Tykarski and Marek Jemielity},
url = {https://www.mdpi.com/2077-0383/13/17/5260},
doi = {10.3390/jcm13175260},
issn = {2077-0383},
year = {2024},
date = {2024-09-01},
urldate = {2024-10-28},
journal = {Journal of Clinical Medicine},
volume = {13},
number = {17},
pages = {5260},
abstract = {Background: Multiple risk factors for coronary artery disease have been identified without answering one of the leading questions related to the extent of the involvement of the epicardial arteries. Trace elements are involved in various stages of atherosclerotic lesion formation and may play a significant role in the advancement of coronary artery disease. Methods: A total of 157 (92 (59%) men and 65 (41%) women) patients with a median age of 71 (65–75) years presenting with chronic coronary syndrome were enrolled in the prospective single-center analysis. The coronary angiography results were compared with the concentration of trace elements in scalp hair. Results: Through Spearman analysis, a positive correlation between the number of diseased coronary arteries and hair trace element concentration was found for sodium (r = 0.198},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Background: Multiple risk factors for coronary artery disease have been identified without answering one of the leading questions related to the extent of the involvement of the epicardial arteries. Trace elements are involved in various stages of atherosclerotic lesion formation and may play a significant role in the advancement of coronary artery disease. Methods: A total of 157 (92 (59%) men and 65 (41%) women) patients with a median age of 71 (65–75) years presenting with chronic coronary syndrome were enrolled in the prospective single-center analysis. The coronary angiography results were compared with the concentration of trace elements in scalp hair. Results: Through Spearman analysis, a positive correlation between the number of diseased coronary arteries and hair trace element concentration was found for sodium (r = 0.198
Lipiński, Patryk; Różdżyńska-Świątkowska, Agnieszka; Ługowska, Agnieszka; Marucha, Jolanta; Drabko, Katarzyna; Tylki-Szymańska, Anna
Body Height of MPS I and II Patients after Hematopoietic Stem Cell Transplantation: The Impact of Dermatan Sulphate Journal Article
In: Diagnostics, vol. 14, no. 17, pp. 1956, 2024, ISSN: 2075-4418.
@article{lipinski_body_2024,
title = {Body Height of MPS I and II Patients after Hematopoietic Stem Cell Transplantation: The Impact of Dermatan Sulphate},
author = {Patryk Lipiński and Agnieszka Różdżyńska-Świątkowska and Agnieszka Ługowska and Jolanta Marucha and Katarzyna Drabko and Anna Tylki-Szymańska},
url = {https://www.mdpi.com/2075-4418/14/17/1956},
doi = {10.3390/diagnostics14171956},
issn = {2075-4418},
year = {2024},
date = {2024-09-01},
urldate = {2024-10-28},
journal = {Diagnostics},
volume = {14},
number = {17},
pages = {1956},
abstract = {Introduction: Hematopoietic stem cell transplantation (HSCT) comprises one of the two main treatment regimens for patients with mucopolysaccharidoses (MPS). There is a scarcity of literature concerning the process of growth in children with Mucopolysaccharidosis type I (MPS I) and Mucopolysaccharidosis type I (MPS II) after HSCT. The aim of this manuscript was to evaluate the therapeutic effect of HSCT on the heights of patients with MPS I and MPS II. Material and methods: It was an observational, single-center study on patients with MPS I and II treated with HSCT. Results: 6 MPS patients, including 4 MPS I and 2 MPS II, underwent HSCT at a median age of 2 years. All patients are alive to date, with a median age of 7.7 years (range 5.5–12 years) at the last follow-up. In both (MPS I and MPS II) groups of patients treated with HSCT, the growth rate was higher than in untreated patients and was found to be in line with the population norm. In both MPS I and MPS II patients who were treated with HSCT, normalization of urinary GAG excretion was observed. Additionally, no bands of DS and HS in GAG electrophoresis were visible. Conclusions: Both MPS I and MPS II patients presented height gain after HSCT compared to the curves of untreated patients. The absence of dermatan sulphate after HSCT could lead to normal growth in bone length.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Introduction: Hematopoietic stem cell transplantation (HSCT) comprises one of the two main treatment regimens for patients with mucopolysaccharidoses (MPS). There is a scarcity of literature concerning the process of growth in children with Mucopolysaccharidosis type I (MPS I) and Mucopolysaccharidosis type I (MPS II) after HSCT. The aim of this manuscript was to evaluate the therapeutic effect of HSCT on the heights of patients with MPS I and MPS II. Material and methods: It was an observational, single-center study on patients with MPS I and II treated with HSCT. Results: 6 MPS patients, including 4 MPS I and 2 MPS II, underwent HSCT at a median age of 2 years. All patients are alive to date, with a median age of 7.7 years (range 5.5–12 years) at the last follow-up. In both (MPS I and MPS II) groups of patients treated with HSCT, the growth rate was higher than in untreated patients and was found to be in line with the population norm. In both MPS I and MPS II patients who were treated with HSCT, normalization of urinary GAG excretion was observed. Additionally, no bands of DS and HS in GAG electrophoresis were visible. Conclusions: Both MPS I and MPS II patients presented height gain after HSCT compared to the curves of untreated patients. The absence of dermatan sulphate after HSCT could lead to normal growth in bone length.
Khabbache, Hicham; Ali, Driss Ait; Cherqui, Abdelhalim; Allioui, Abdelaziz; Abidli, Zakaria; Elturk, Joumana; Yildirim, Murat; Bragazzi, Nicola Luigi; Nucera, Gabriella; Szarpak, Lukasz; Rizzo, Amelia; Chirico, Francesco
Adaptation and validation of the Moroccan dialect version of the nomophobia questionnaire (NMP-Q): Among university students Journal Article
In: Heliyon, vol. 10, no. 17, pp. e36256, 2024, ISSN: 24058440.
@article{khabbache_adaptation_2024,
title = {Adaptation and validation of the Moroccan dialect version of the nomophobia questionnaire (NMP-Q): Among university students},
author = {Hicham Khabbache and Driss Ait Ali and Abdelhalim Cherqui and Abdelaziz Allioui and Zakaria Abidli and Joumana Elturk and Murat Yildirim and Nicola Luigi Bragazzi and Gabriella Nucera and Lukasz Szarpak and Amelia Rizzo and Francesco Chirico},
url = {https://linkinghub.elsevier.com/retrieve/pii/S2405844024122876},
doi = {10.1016/j.heliyon.2024.e36256},
issn = {24058440},
year = {2024},
date = {2024-09-01},
urldate = {2024-10-28},
journal = {Heliyon},
volume = {10},
number = {17},
pages = {e36256},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Procyk, Grzegorz; Jaworski, Jakub; Gąsecka, Aleksandra; Filipiak, Krzysztof J.; Borovac, Josip A.
Metabolic dysfunction-associated steatotic liver disease - A new indication for sodium-glucose Co-transporter-2 inhibitors Journal Article
In: Advances in Medical Sciences, vol. 69, no. 2, pp. 407–415, 2024, ISSN: 18961126.
@article{procyk_metabolic_2024,
title = {Metabolic dysfunction-associated steatotic liver disease - A new indication for sodium-glucose Co-transporter-2 inhibitors},
author = {Grzegorz Procyk and Jakub Jaworski and Aleksandra Gąsecka and Krzysztof J. Filipiak and Josip A. Borovac},
url = {https://linkinghub.elsevier.com/retrieve/pii/S189611262400049X},
doi = {10.1016/j.advms.2024.09.001},
issn = {18961126},
year = {2024},
date = {2024-09-01},
urldate = {2024-10-28},
journal = {Advances in Medical Sciences},
volume = {69},
number = {2},
pages = {407–415},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Pruc, Michal; Zembala, Michal; Tomaszewska, Monika; Szarpak, Lukasz
Personalized oxygen targets are needed for extracorporeal membrane oxygenation Journal Article
In: Intensive Care Medicine, 2024, ISSN: 0342-4642, 1432-1238.
@article{pruc_personalized_2024,
title = {Personalized oxygen targets are needed for extracorporeal membrane oxygenation},
author = {Michal Pruc and Michal Zembala and Monika Tomaszewska and Lukasz Szarpak},
url = {https://link.springer.com/10.1007/s00134-024-07638-7},
doi = {10.1007/s00134-024-07638-7},
issn = {0342-4642, 1432-1238},
year = {2024},
date = {2024-09-01},
urldate = {2024-10-28},
journal = {Intensive Care Medicine},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Chmielewski, Jarosław; Wojciechowska, Mariola; Chirico, Francesco; Crescenzo, Pietro; Rizzo, Amelia; Starz, Roman; Yıldırım, Murat; Olcay, Zeynep Feride; Szarpak, Łukasz; Strzelecka, Agnieszka; Lutomski, Piotr; Szarpak, Agnieszka; Tomaszewska, Monika; Wójcik, Tomasz
Job burnout in a sample of Polish paramedics – role of work experience, age and health behaviours Journal Article
In: Annals of Agricultural and Environmental Medicine, vol. 31, no. 3, pp. 395–400, 2024, ISSN: 1232-1966, 1898-2263.
@article{chmielewski_job_2024,
title = {Job burnout in a sample of Polish paramedics – role of work experience, age and health behaviours},
author = {Jarosław Chmielewski and Mariola Wojciechowska and Francesco Chirico and Pietro Crescenzo and Amelia Rizzo and Roman Starz and Murat Yıldırım and Zeynep Feride Olcay and Łukasz Szarpak and Agnieszka Strzelecka and Piotr Lutomski and Agnieszka Szarpak and Monika Tomaszewska and Tomasz Wójcik},
url = {https://www.aaem.pl/Job-burnout-in-a-sample-of-Polish-paramedics-role-of-work-experience-age-and-health,191526,0,2.html},
doi = {10.26444/aaem/191526},
issn = {1232-1966, 1898-2263},
year = {2024},
date = {2024-09-01},
urldate = {2024-11-02},
journal = {Annals of Agricultural and Environmental Medicine},
volume = {31},
number = {3},
pages = {395–400},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Sirek, Tomasz; Sirek, Agata; Borawski, Przemysław; Zmarzły, Nikola; Sułkowska, Joanna; Król-Jatręga, Katarzyna; Opławski, Marcin; Boroń, Dariusz; Chalcarz, Michał; Ossowski, Piotr; Dziobek, Konrad; Strojny, Damian; Boroń, Kacper; Janiszewska-Bil, Dominika; Grabarek, Beniamin Oskar
miRNAs in Signal Transduction of SMAD Proteins in Breast Cancer Journal Article
In: International Journal of Molecular Sciences, vol. 25, no. 18, pp. 10088, 2024, ISSN: 1422-0067.
@article{sirek_mirnas_2024,
title = {miRNAs in Signal Transduction of SMAD Proteins in Breast Cancer},
author = {Tomasz Sirek and Agata Sirek and Przemysław Borawski and Nikola Zmarzły and Joanna Sułkowska and Katarzyna Król-Jatręga and Marcin Opławski and Dariusz Boroń and Michał Chalcarz and Piotr Ossowski and Konrad Dziobek and Damian Strojny and Kacper Boroń and Dominika Janiszewska-Bil and Beniamin Oskar Grabarek},
url = {https://www.mdpi.com/1422-0067/25/18/10088},
doi = {10.3390/ijms251810088},
issn = {1422-0067},
year = {2024},
date = {2024-09-01},
urldate = {2024-11-05},
journal = {International Journal of Molecular Sciences},
volume = {25},
number = {18},
pages = {10088},
abstract = {The aim of this study was to identify miRNAs that could potentially influence the activity of SMAD proteins involved in TGFβ signal transduction in five types of breast cancer in Polish women. Patients with five breast cancer subtypes were included in the study: luminal A (n = 130), luminal B HER2− (n = 100), luminal B HER2+ (n = 96), non-luminal HER2+ (n = 36), and TNBC (n = 43). During surgery, tumor tissue was removed along with a margin of healthy tissue (control). Molecular analysis included determination of the expression of genes related to SMAD protein signal transduction using mRNA microarrays and reverse transcription quantitative polymerase chain reaction (RT-qPCR). Protein expression was determined using an enzyme-linked immunosorbent assay (ELISA). The miRNA profiling was performed using miRNA microarrays and the miRDB database. SMAD3 and SMAD5 were overexpressed in all types of breast cancer, which could be related to the reduced expression of miR-145, and the findings for SMAD4 and miR-155 were similar. Additionally, the level of SMAD7 was reduced, which may be due to the low activity of miR-15b and miR21b. This study determined the gene expression profiles involved in SMAD protein signal transduction across five different types of breast cancer and identified the miRNAs potentially regulating their activity. Overexpression of SMAD3, SMAD4, and SMAD5 suggests excessive activation of the TGFβ pathway, potentially promoting tumor growth and development. Concurrently, a significant reduction in SMAD7 expression removes inhibitory control in the TGFβ pathway, a phenomenon that is particularly evident in more aggressive breast cancer types.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
The aim of this study was to identify miRNAs that could potentially influence the activity of SMAD proteins involved in TGFβ signal transduction in five types of breast cancer in Polish women. Patients with five breast cancer subtypes were included in the study: luminal A (n = 130), luminal B HER2− (n = 100), luminal B HER2+ (n = 96), non-luminal HER2+ (n = 36), and TNBC (n = 43). During surgery, tumor tissue was removed along with a margin of healthy tissue (control). Molecular analysis included determination of the expression of genes related to SMAD protein signal transduction using mRNA microarrays and reverse transcription quantitative polymerase chain reaction (RT-qPCR). Protein expression was determined using an enzyme-linked immunosorbent assay (ELISA). The miRNA profiling was performed using miRNA microarrays and the miRDB database. SMAD3 and SMAD5 were overexpressed in all types of breast cancer, which could be related to the reduced expression of miR-145, and the findings for SMAD4 and miR-155 were similar. Additionally, the level of SMAD7 was reduced, which may be due to the low activity of miR-15b and miR21b. This study determined the gene expression profiles involved in SMAD protein signal transduction across five different types of breast cancer and identified the miRNAs potentially regulating their activity. Overexpression of SMAD3, SMAD4, and SMAD5 suggests excessive activation of the TGFβ pathway, potentially promoting tumor growth and development. Concurrently, a significant reduction in SMAD7 expression removes inhibitory control in the TGFβ pathway, a phenomenon that is particularly evident in more aggressive breast cancer types.
Urbanowicz, Tomasz; Wojtasińska, Ewelina; Olasińska-Wiśniewska, Anna; Filipiak, Krzysztof J; Ładzińska, Małgorzata; Sikora, Jędrzej; Straburzyńska-Migaj, Ewa; Tykarski, Andrzej; Jemielity, Marek; Rupa-Matysek, Joanna
In: Polish Heart Journal, vol. 82, no. 7-8, pp. 777–779, 2024, ISSN: 1897-4279, 0022-9032.
@article{urbanowicz_neutrophil_2024-1,
title = {Neutrophil to extracellular traps (NETs) as an early marker of right ventricular dilatation in patients with left ventricular assist devices (LVAD)},
author = {Tomasz Urbanowicz and Ewelina Wojtasińska and Anna Olasińska-Wiśniewska and Krzysztof J Filipiak and Małgorzata Ładzińska and Jędrzej Sikora and Ewa Straburzyńska-Migaj and Andrzej Tykarski and Marek Jemielity and Joanna Rupa-Matysek},
url = {https://journals.viamedica.pl/polish_heart_journal/article/view/100884},
doi = {10.33963/v.phj.100884},
issn = {1897-4279, 0022-9032},
year = {2024},
date = {2024-08-01},
urldate = {2024-10-28},
journal = {Polish Heart Journal},
volume = {82},
number = {7-8},
pages = {777–779},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Smereka, Jacek; Pruc, Michal; Cyran, Maciej; Szarpak, Lukasz
The relationship of malnutrition, frailty, and sarcopenia in critical care Journal Article
In: Intensive Care Medicine, 2024, ISSN: 0342-4642, 1432-1238.
@article{smereka_relationship_2024,
title = {The relationship of malnutrition, frailty, and sarcopenia in critical care},
author = {Jacek Smereka and Michal Pruc and Maciej Cyran and Lukasz Szarpak},
url = {https://link.springer.com/10.1007/s00134-024-07595-1},
doi = {10.1007/s00134-024-07595-1},
issn = {0342-4642, 1432-1238},
year = {2024},
date = {2024-08-01},
urldate = {2024-10-28},
journal = {Intensive Care Medicine},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Jaguszewski, Milosz J.; Pruc, Michal; Szarpak, Lukasz
The prediction of alterations in plasma sodium levels in acutely ill patients should be more comprehensive Journal Article
In: European Journal of Internal Medicine, pp. S0953620524003510, 2024, ISSN: 09536205.
@article{jaguszewski_prediction_2024,
title = {The prediction of alterations in plasma sodium levels in acutely ill patients should be more comprehensive},
author = {Milosz J. Jaguszewski and Michal Pruc and Lukasz Szarpak},
url = {https://linkinghub.elsevier.com/retrieve/pii/S0953620524003510},
doi = {10.1016/j.ejim.2024.08.013},
issn = {09536205},
year = {2024},
date = {2024-08-01},
urldate = {2024-10-28},
journal = {European Journal of Internal Medicine},
pages = {S0953620524003510},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Macech, Adam; Bragazzi, Nicola Luigi; Chirico, Francesco; Cander, Basar; Pruc, Michal; Rafique, Zubaid; Peacock, William Frank; Ziapour, Arash; Szarpak, Lukasz; Salak, Anna; Jaguszewski, Milosz J.
Efficacy of etripamil nasal spray for acute conversion of supraventricular tachycardia: a network meta-analysis Journal Article
In: Cardiology Journal, vol. 31, no. 4, pp. 640–642, 2024, ISSN: 1898-018X, 1897-5593.
@article{macech_efficacy_2024,
title = {Efficacy of etripamil nasal spray for acute conversion of supraventricular tachycardia: a network meta-analysis},
author = {Adam Macech and Nicola Luigi Bragazzi and Francesco Chirico and Basar Cander and Michal Pruc and Zubaid Rafique and William Frank Peacock and Arash Ziapour and Lukasz Szarpak and Anna Salak and Milosz J. Jaguszewski},
url = {https://journals.viamedica.pl/cardiology_journal/article/view/100869},
doi = {10.5603/cj.100869},
issn = {1898-018X, 1897-5593},
year = {2024},
date = {2024-08-01},
urldate = {2024-10-28},
journal = {Cardiology Journal},
volume = {31},
number = {4},
pages = {640–642},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Pruc, Michal; Gaca, Zuzanna; Swieczkowski, Damian; Kubica, Jacek; Galwankar, Sagar; Salak, Anna; Szarpak, Lukasz
A Systematic Review and Meta-Analysis of the Diagnostic Value of Galectin-3 in Acute Coronary Syndrome Journal Article
In: Journal of Clinical Medicine, vol. 13, no. 15, pp. 4504, 2024, ISSN: 2077-0383.
@article{pruc_systematic_2024,
title = {A Systematic Review and Meta-Analysis of the Diagnostic Value of Galectin-3 in Acute Coronary Syndrome},
author = {Michal Pruc and Zuzanna Gaca and Damian Swieczkowski and Jacek Kubica and Sagar Galwankar and Anna Salak and Lukasz Szarpak},
url = {https://www.mdpi.com/2077-0383/13/15/4504},
doi = {10.3390/jcm13154504},
issn = {2077-0383},
year = {2024},
date = {2024-08-01},
urldate = {2024-10-28},
journal = {Journal of Clinical Medicine},
volume = {13},
number = {15},
pages = {4504},
abstract = {Background/Objectives: We investigated the potential diagnostic role of galectin-3 (Gal-3) in patients presenting with suspected acute coronary syndromes (ACS). Methods: We searched PubMed Central, Scopus, EMBASE, and the Cochrane Library from inception until 20 June 2024. We measured effect sizes using odds ratios (OR) with 95% CIs for dichotomous data and mean differences (MD) with CIs for continuous data. Random synthesis analysis was performed if I2 was less than 50% or Q test p values were less than 0.05. Otherwise, a fixed pooled meta-analysis was performed. Results: The meta-analysis includes 15 eligible studies. Gal-3 levels were substantially higher in the ACS group (12.84 ± 8.48 ng/mL) compared to the control group (7.23 ± 6.05 ng/mL; MD = 3.89; 95% CI: 2.83 to 4.95; p < 0.001). Gal-3 levels in acute myocardial infarction (AMI) and control groups differed (10.09 ± 8.16 vs. 4.64 ± 3.07 ng/mL},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Background/Objectives: We investigated the potential diagnostic role of galectin-3 (Gal-3) in patients presenting with suspected acute coronary syndromes (ACS). Methods: We searched PubMed Central, Scopus, EMBASE, and the Cochrane Library from inception until 20 June 2024. We measured effect sizes using odds ratios (OR) with 95% CIs for dichotomous data and mean differences (MD) with CIs for continuous data. Random synthesis analysis was performed if I2 was less than 50% or Q test p values were less than 0.05. Otherwise, a fixed pooled meta-analysis was performed. Results: The meta-analysis includes 15 eligible studies. Gal-3 levels were substantially higher in the ACS group (12.84 ± 8.48 ng/mL) compared to the control group (7.23 ± 6.05 ng/mL; MD = 3.89; 95% CI: 2.83 to 4.95; p < 0.001). Gal-3 levels in acute myocardial infarction (AMI) and control groups differed (10.09 ± 8.16 vs. 4.64 ± 3.07 ng/mL
Jankowska, Irena; Socha, Piotr; Gliwicz, Dorota; Lipiński, Patryk; Rokicki, Dariusz; Kaliciński, Piotr; Danielewska, Ewa; Grenda, Ryszard
Modified by the Innovative Drugs and Strategies—Pattern of Selected Indications for Pediatric Liver Transplantation Journal Article
In: Pediatric Transplantation, vol. 28, no. 5, pp. e14825, 2024, ISSN: 1397-3142, 1399-3046.
@article{jankowska_modified_2024,
title = {Modified by the Innovative Drugs and Strategies—Pattern of Selected Indications for Pediatric Liver Transplantation},
author = {Irena Jankowska and Piotr Socha and Dorota Gliwicz and Patryk Lipiński and Dariusz Rokicki and Piotr Kaliciński and Ewa Danielewska and Ryszard Grenda},
url = {https://onlinelibrary.wiley.com/doi/10.1111/petr.14825},
doi = {10.1111/petr.14825},
issn = {1397-3142, 1399-3046},
year = {2024},
date = {2024-08-01},
urldate = {2024-10-28},
journal = {Pediatric Transplantation},
volume = {28},
number = {5},
pages = {e14825},
abstract = {ABSTRACT
Background
Liver transplantation (LTx) constitutes a major life‐saving routine treatment for children with end‐stage liver disease. However, the analysis of LTx registries in children provides much information about changes in the indication profiles in the recent years.
Methods
The article provides a comprehensive review about the successes, hopes, and challenges related to changing indications for LTx in children based on the literature review and our own experience. Retrospective review of the indications for LTx at a tertiary referral pediatric hospital was also presented.
Results and Conclusions
In the context of the new therapies that have emerged, the need for LTx has decreased in patients with chronic hepatitis B and C infection and tyrosinemia type 1. In primary hyperoxaluria type 1, new RNAi‐based therapy has eliminated the requirement for LTx (both isolated or combined). There is a hope that introduction of ileal bile acid transporter (IBAT) blockers reduces the need for LTx in patients with Alagille syndrome or progressive familial intrahepatic cholestasis. The number of children qualified for LTx with urea cycle disorders (UCDs) as a prophylaxis of neurodevelopmental impairment is increasing.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
ABSTRACT
Background
Liver transplantation (LTx) constitutes a major life‐saving routine treatment for children with end‐stage liver disease. However, the analysis of LTx registries in children provides much information about changes in the indication profiles in the recent years.
Methods
The article provides a comprehensive review about the successes, hopes, and challenges related to changing indications for LTx in children based on the literature review and our own experience. Retrospective review of the indications for LTx at a tertiary referral pediatric hospital was also presented.
Results and Conclusions
In the context of the new therapies that have emerged, the need for LTx has decreased in patients with chronic hepatitis B and C infection and tyrosinemia type 1. In primary hyperoxaluria type 1, new RNAi‐based therapy has eliminated the requirement for LTx (both isolated or combined). There is a hope that introduction of ileal bile acid transporter (IBAT) blockers reduces the need for LTx in patients with Alagille syndrome or progressive familial intrahepatic cholestasis. The number of children qualified for LTx with urea cycle disorders (UCDs) as a prophylaxis of neurodevelopmental impairment is increasing.
Background
Liver transplantation (LTx) constitutes a major life‐saving routine treatment for children with end‐stage liver disease. However, the analysis of LTx registries in children provides much information about changes in the indication profiles in the recent years.
Methods
The article provides a comprehensive review about the successes, hopes, and challenges related to changing indications for LTx in children based on the literature review and our own experience. Retrospective review of the indications for LTx at a tertiary referral pediatric hospital was also presented.
Results and Conclusions
In the context of the new therapies that have emerged, the need for LTx has decreased in patients with chronic hepatitis B and C infection and tyrosinemia type 1. In primary hyperoxaluria type 1, new RNAi‐based therapy has eliminated the requirement for LTx (both isolated or combined). There is a hope that introduction of ileal bile acid transporter (IBAT) blockers reduces the need for LTx in patients with Alagille syndrome or progressive familial intrahepatic cholestasis. The number of children qualified for LTx with urea cycle disorders (UCDs) as a prophylaxis of neurodevelopmental impairment is increasing.
Pruc, Michal; Jannasz, Iwona; Swieczkowski, Damian; Procyk, Grzegorz; Gasecka, Aleksandra; Rafique, Zubaid; Chirico, Francesco; Bragazzi, Nicola Luigi; Jaguszewski, Milosz J.; Wysocki, Jaroslaw; Szarpak, Lukasz
In: Cardiology Journal, vol. 31, no. 4, pp. 564–572, 2024, ISSN: 1898-018X, 1897-5593.
@article{pruc_diagnostic_2024,
title = {Diagnostic value of soluble urokinase‐type plasminogen activator receptor in patients with acute coronary syndrome: A systematic review and meta-analysis},
author = {Michal Pruc and Iwona Jannasz and Damian Swieczkowski and Grzegorz Procyk and Aleksandra Gasecka and Zubaid Rafique and Francesco Chirico and Nicola Luigi Bragazzi and Milosz J. Jaguszewski and Jaroslaw Wysocki and Lukasz Szarpak},
url = {https://journals.viamedica.pl/cardiology_journal/article/view/96228},
doi = {10.5603/cj.96228},
issn = {1898-018X, 1897-5593},
year = {2024},
date = {2024-08-01},
urldate = {2024-10-28},
journal = {Cardiology Journal},
volume = {31},
number = {4},
pages = {564–572},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Urbanowicz, Tomasz; Michalak, Michał; Komosa, Anna; Olasińska-Wiśniewska, Anna; Filipiak, Krzysztof J.; Tykarski, Andrzej; Jemielity, Marek
In: Cardiology Journal, vol. 31, no. 4, pp. 583–595, 2024, ISSN: 1898-018X, 1897-5593.
@article{urbanowicz_predictive_2024,
title = {Predictive value of systemic inflammatory response index (SIRI) for complex coronary artery disease occurrence in patients presenting with angina equivalent symptoms},
author = {Tomasz Urbanowicz and Michał Michalak and Anna Komosa and Anna Olasińska-Wiśniewska and Krzysztof J. Filipiak and Andrzej Tykarski and Marek Jemielity},
url = {https://journals.viamedica.pl/cardiology_journal/article/view/92829},
doi = {10.5603/CJ.a2023.0033},
issn = {1898-018X, 1897-5593},
year = {2024},
date = {2024-08-01},
urldate = {2024-10-28},
journal = {Cardiology Journal},
volume = {31},
number = {4},
pages = {583–595},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Sirek, Tomasz; Sirek, Agata; Opławski, Marcin; Boroń, Dariusz; Chalcarz, Michał; Ossowski, Piotr; Dziobek, Konrad; Zmarzły, Nikola; Strojny, Damian; Grabarek, Beniamin Oskar
Expression profile of messenger and micro RNAs related to the histaminergic system in patients with five subtypes of breast cancer Journal Article
In: Frontiers in Oncology, vol. 14, pp. 1407538, 2024, ISSN: 2234-943X.
@article{sirek_expression_2024,
title = {Expression profile of messenger and micro RNAs related to the histaminergic system in patients with five subtypes of breast cancer},
author = {Tomasz Sirek and Agata Sirek and Marcin Opławski and Dariusz Boroń and Michał Chalcarz and Piotr Ossowski and Konrad Dziobek and Nikola Zmarzły and Damian Strojny and Beniamin Oskar Grabarek},
url = {https://www.frontiersin.org/articles/10.3389/fonc.2024.1407538/full},
doi = {10.3389/fonc.2024.1407538},
issn = {2234-943X},
year = {2024},
date = {2024-08-01},
urldate = {2024-10-28},
journal = {Frontiers in Oncology},
volume = {14},
pages = {1407538},
abstract = {Disparities in estrogen receptor (ER), progesterone receptor, human epidermal growth factor receptor 2 (HER2), and Ki67 proliferation indices facilitate the categorization of breast cancer into four principal subtypes: luminal A, luminal B, HER2-positive, and triple-negative breast cancer (TNBC). Preclinical studies investigating the therapeutic potential of histaminergic system targeting in breast cancer have shown promising results. This study aimed to assess the expression profiles of messenger ribonucleic acid (mRNA) and micro RNA (miRNA) related to the histaminergic system in five subtypes of breast cancer among Polish women. Patients with five breast cancer subtypes were included in the study: luminal A (n = 130), luminal B (n = 196, including HER2-},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Disparities in estrogen receptor (ER), progesterone receptor, human epidermal growth factor receptor 2 (HER2), and Ki67 proliferation indices facilitate the categorization of breast cancer into four principal subtypes: luminal A, luminal B, HER2-positive, and triple-negative breast cancer (TNBC). Preclinical studies investigating the therapeutic potential of histaminergic system targeting in breast cancer have shown promising results. This study aimed to assess the expression profiles of messenger ribonucleic acid (mRNA) and micro RNA (miRNA) related to the histaminergic system in five subtypes of breast cancer among Polish women. Patients with five breast cancer subtypes were included in the study: luminal A (n = 130), luminal B (n = 196, including HER2-
Gasecka, Aleksandra; Błażejowska, Ewelina; Pluta, Kinga; Gajewska, Magdalena; Rogula, Sylwester; Filipiak, Krzysztof J.; Kochman, Janusz; Siller-Matula, Jolanta M.; Postuła, Marek; Eyileten, Ceren
Ticagrelor downregulates the expression of proatherogenic and proinflammatory miR125-b compared to clopidogrel: A randomized, controlled trial Journal Article
In: International Journal of Cardiology, vol. 406, pp. 132073, 2024, ISSN: 0167-5273, (Publisher: Elsevier BV).
@article{gasecka_ticagrelor_2024,
title = {Ticagrelor downregulates the expression of proatherogenic and proinflammatory miR125-b compared to clopidogrel: A randomized, controlled trial},
author = {Aleksandra Gasecka and Ewelina Błażejowska and Kinga Pluta and Magdalena Gajewska and Sylwester Rogula and Krzysztof J. Filipiak and Janusz Kochman and Jolanta M. Siller-Matula and Marek Postuła and Ceren Eyileten},
url = {https://linkinghub.elsevier.com/retrieve/pii/S0167527324006934},
doi = {10.1016/j.ijcard.2024.132073},
issn = {0167-5273},
year = {2024},
date = {2024-07-01},
urldate = {2024-09-17},
journal = {International Journal of Cardiology},
volume = {406},
pages = {132073},
note = {Publisher: Elsevier BV},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Urbanowicz, Tomasz; Skotak, Krzysztof; Bratkowski, Jakub; Olasińska-Wiśniewska, Anna; Filipiak, Krzysztof J.; Michalak, Michał; Grodecki, Kajetan; Szczepański, Krystian; Tykarski, Andrzej; Krasińska, Beata; Krasiński, Zbigniew; Krasińska-Płachta, Aleksandra; Jemielity, Marek
Long-Term Survival after Coronary Artery Surgical Revascularization—Does Ambient Temperature Matter? Journal Article
In: Medicina, vol. 60, no. 8, pp. 1220, 2024, ISSN: 1648-9144.
@article{urbanowicz_long-term_2024,
title = {Long-Term Survival after Coronary Artery Surgical Revascularization—Does Ambient Temperature Matter?},
author = {Tomasz Urbanowicz and Krzysztof Skotak and Jakub Bratkowski and Anna Olasińska-Wiśniewska and Krzysztof J. Filipiak and Michał Michalak and Kajetan Grodecki and Krystian Szczepański and Andrzej Tykarski and Beata Krasińska and Zbigniew Krasiński and Aleksandra Krasińska-Płachta and Marek Jemielity},
url = {https://www.mdpi.com/1648-9144/60/8/1220},
doi = {10.3390/medicina60081220},
issn = {1648-9144},
year = {2024},
date = {2024-07-01},
urldate = {2024-10-28},
journal = {Medicina},
volume = {60},
number = {8},
pages = {1220},
abstract = {Background and Objectives: The progression of global warming results in an increased exposure to extreme heat, leading to exaggeration of preexisting diseases and premature deaths. The aim of the study was to present possible risk factors for all-cause long-term mortality in patients who underwent surgical revascularization, including an assessment of the influence of ambient temperature exposure. Materials and Methods: Retrospective analysis included 153 (123 (80%) males and 30 (20%) females) patients who underwent off-pump revascularization and were followed for a median time of 2533 (1035–3250) days. The demographical, clinical data and ambient temperature exposure were taken into analysis for prediction of all-cause mortality. Individual exposure was calculated based on the place of habitation. Results: In the multivariate logistic regression model with backward stepwise elimination method, risk factors such as dyslipidaemia (p = 0.001), kidney disease (p = 0.005), age (p = 0.006), and body mass index (p = 0.007) were found to be significant for late mortality prediction. In addition to traditional factors, environmental characteristics, including tropical nights (p = 0.043), were revealed to be significant. Conclusions: High night-time ambient temperatures known as tropical nights may be regarded as additional long-term mortality risk factor after surgical revascularization.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Background and Objectives: The progression of global warming results in an increased exposure to extreme heat, leading to exaggeration of preexisting diseases and premature deaths. The aim of the study was to present possible risk factors for all-cause long-term mortality in patients who underwent surgical revascularization, including an assessment of the influence of ambient temperature exposure. Materials and Methods: Retrospective analysis included 153 (123 (80%) males and 30 (20%) females) patients who underwent off-pump revascularization and were followed for a median time of 2533 (1035–3250) days. The demographical, clinical data and ambient temperature exposure were taken into analysis for prediction of all-cause mortality. Individual exposure was calculated based on the place of habitation. Results: In the multivariate logistic regression model with backward stepwise elimination method, risk factors such as dyslipidaemia (p = 0.001), kidney disease (p = 0.005), age (p = 0.006), and body mass index (p = 0.007) were found to be significant for late mortality prediction. In addition to traditional factors, environmental characteristics, including tropical nights (p = 0.043), were revealed to be significant. Conclusions: High night-time ambient temperatures known as tropical nights may be regarded as additional long-term mortality risk factor after surgical revascularization.
Pruc, Michal; Szarpak, Lukasz
In: European Journal of Internal Medicine, pp. S0953620524003224, 2024, ISSN: 09536205.
@article{pruc_long-term_2024,
title = {Long-term inhaled corticosteroid treatment in patients with chronic obstructive lung disease, cardiovascular disease, and recent hospitalization for exacerbation},
author = {Michal Pruc and Lukasz Szarpak},
url = {https://linkinghub.elsevier.com/retrieve/pii/S0953620524003224},
doi = {10.1016/j.ejim.2024.07.025},
issn = {09536205},
year = {2024},
date = {2024-07-01},
urldate = {2024-10-28},
journal = {European Journal of Internal Medicine},
pages = {S0953620524003224},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Dubiela, Pawel; Szymanska-Rozek, Paulina; Hasinski, Piotr; Lipinski, Patryk; Kleinotiene, Grazina; Giersz, Dorota; Tylki-Szymanska, Anna
Long- and Short-Term Glucosphingosine (lyso-Gb1) Dynamics in Gaucher Patients Undergoing Enzyme Replacement Therapy Journal Article
In: Biomolecules, vol. 14, no. 7, pp. 842, 2024, ISSN: 2218-273X.
@article{dubiela_long-_2024,
title = {Long- and Short-Term Glucosphingosine (lyso-Gb1) Dynamics in Gaucher Patients Undergoing Enzyme Replacement Therapy},
author = {Pawel Dubiela and Paulina Szymanska-Rozek and Piotr Hasinski and Patryk Lipinski and Grazina Kleinotiene and Dorota Giersz and Anna Tylki-Szymanska},
url = {https://www.mdpi.com/2218-273X/14/7/842},
doi = {10.3390/biom14070842},
issn = {2218-273X},
year = {2024},
date = {2024-07-01},
urldate = {2024-10-28},
journal = {Biomolecules},
volume = {14},
number = {7},
pages = {842},
abstract = {Background: Gaucher disease (GD) is a lysosomal storage disorder caused by mutations in the GBA1 gene, leading to β-glucocerebrosidase deficiency and glucosylceramide accumulation. Methods: We analyzed short- and long-term dynamics of lyso-glucosylceramide (lyso-Gb1) in a large cohort of GD patients undergoing enzyme replacement therapy (ERT). Results: Eight-years analysis of lyso-Gb1 revealed statistically insignificant variability in the biomarker across the years and relatively high individual variability in patients’ results. GD type 1 (GD1) patients exhibited higher variability compared to GD type 3 (GD3) patients (coefficients of variation: 34% and 23%, respectively; p-value = 0.0003). We also investigated the short-term response of the biomarker to enzyme replacement therapy (ERT), measuring lyso-Gb1 right before and 30 min after treatment administration. We tested 20 GD patients (16 GD1, 4 GD3) and observed a rapid and significant reduction in lyso-Gb1 levels (average decrease of 17%; p-value < 0.0001). This immediate response reaffirms the efficacy of ERT in reducing substrate accumulation in GD patients but, on the other hand, suggests the biomarker’s instability between the infusions. Conclusions: These findings underscore lyso-Gb1’s potential as a reliable biomarker for monitoring efficacy of treatment. However, individual variability and dry blood spot (DBS) testing limitations urge a further refinement in clinical application. Our study contributes valuable insights into GD patient management, emphasizing the evolving role of biomarkers in personalized medicine.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Background: Gaucher disease (GD) is a lysosomal storage disorder caused by mutations in the GBA1 gene, leading to β-glucocerebrosidase deficiency and glucosylceramide accumulation. Methods: We analyzed short- and long-term dynamics of lyso-glucosylceramide (lyso-Gb1) in a large cohort of GD patients undergoing enzyme replacement therapy (ERT). Results: Eight-years analysis of lyso-Gb1 revealed statistically insignificant variability in the biomarker across the years and relatively high individual variability in patients’ results. GD type 1 (GD1) patients exhibited higher variability compared to GD type 3 (GD3) patients (coefficients of variation: 34% and 23%, respectively; p-value = 0.0003). We also investigated the short-term response of the biomarker to enzyme replacement therapy (ERT), measuring lyso-Gb1 right before and 30 min after treatment administration. We tested 20 GD patients (16 GD1, 4 GD3) and observed a rapid and significant reduction in lyso-Gb1 levels (average decrease of 17%; p-value < 0.0001). This immediate response reaffirms the efficacy of ERT in reducing substrate accumulation in GD patients but, on the other hand, suggests the biomarker’s instability between the infusions. Conclusions: These findings underscore lyso-Gb1’s potential as a reliable biomarker for monitoring efficacy of treatment. However, individual variability and dry blood spot (DBS) testing limitations urge a further refinement in clinical application. Our study contributes valuable insights into GD patient management, emphasizing the evolving role of biomarkers in personalized medicine.
Kozikowski, Mieszko; Zagrodzka, Magdalena; Zawadzki, Marek; Zugaj, Przemysław; Osiecki, Rafał; Rzymkowski, Franciszek; Śledź, Mateusz; Sosnowski, Roman; Dobruch, Jakub; Giudice, Francesco Del; Krajewski, Wojciech
The role of VI-RADS scoring criteria for predicting oncological outcomes in bladder cancer Journal Article
In: World Journal of Urology, vol. 42, no. 1, pp. 438, 2024, ISSN: 1433-8726.
@article{kozikowski_role_2024,
title = {The role of VI-RADS scoring criteria for predicting oncological outcomes in bladder cancer},
author = {Mieszko Kozikowski and Magdalena Zagrodzka and Marek Zawadzki and Przemysław Zugaj and Rafał Osiecki and Franciszek Rzymkowski and Mateusz Śledź and Roman Sosnowski and Jakub Dobruch and Francesco Del Giudice and Wojciech Krajewski},
url = {https://link.springer.com/10.1007/s00345-024-05101-2},
doi = {10.1007/s00345-024-05101-2},
issn = {1433-8726},
year = {2024},
date = {2024-07-01},
urldate = {2024-10-28},
journal = {World Journal of Urology},
volume = {42},
number = {1},
pages = {438},
abstract = {Abstract
Purpose
Our purpose was to evaluate the prognostic value of Vesical Imaging Reporting and Data System (VI-RADS) in bladder cancer (BCa) staging and predicting recurrence or progression.
Methods
We retrospectively analyzed the prospectively collected data from 96 patients with bladder tumors who underwent VI-RADS-based multiparametric magnetic resonance imaging (mpMRI) before endourological treatment from April 2021 to December 2022. Diagnostic performance was evaluated by comparing mpMRI reports with final pathology, using logistic regression for muscle-invasive bladder cancer (MIBC) predictors. Follow-up until May 2023 included Kaplan-Meier and Cox regression analysis to assess VI-RADS predictive roles for recurrence-free survival (RFS) and progression-free survival (PFS).
Results
A total of 96 patients (19.8% women, 80.2% men; median age 68.0 years) were included, with 71% having primary tumors and 29% recurrent BCa. Multiparametric MRI exhibited high sensitivity (92%) and specificity (79%) in predicting MIBC, showing no significant differences between primary and recurrent cancers (AUC: 0.96 vs. 0.92,
P = .565). VI-RADS emerged as a key predictor for MIBC in both univariate (OR: 40.3,
P
< .001) and multivariate (OR: 54.6,
P
< .001) analyses. Primary tumors with VI-RADS ≥ 3 demonstrated significantly shorter RFS (
P = .02) and PFS (
P = .04).
Conclusions
In conclusion, mpMRI with VI-RADS has a high diagnostic value in predicting MIBC in both primary and recurrent BCa. A VI-RADS threshold ≥ 3 is a strong predictor for MIBC, and in primary tumors predicts early recurrence and progression.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Abstract
Purpose
Our purpose was to evaluate the prognostic value of Vesical Imaging Reporting and Data System (VI-RADS) in bladder cancer (BCa) staging and predicting recurrence or progression.
Methods
We retrospectively analyzed the prospectively collected data from 96 patients with bladder tumors who underwent VI-RADS-based multiparametric magnetic resonance imaging (mpMRI) before endourological treatment from April 2021 to December 2022. Diagnostic performance was evaluated by comparing mpMRI reports with final pathology, using logistic regression for muscle-invasive bladder cancer (MIBC) predictors. Follow-up until May 2023 included Kaplan-Meier and Cox regression analysis to assess VI-RADS predictive roles for recurrence-free survival (RFS) and progression-free survival (PFS).
Results
A total of 96 patients (19.8% women, 80.2% men; median age 68.0 years) were included, with 71% having primary tumors and 29% recurrent BCa. Multiparametric MRI exhibited high sensitivity (92%) and specificity (79%) in predicting MIBC, showing no significant differences between primary and recurrent cancers (AUC: 0.96 vs. 0.92,
P = .565). VI-RADS emerged as a key predictor for MIBC in both univariate (OR: 40.3,
P
< .001) and multivariate (OR: 54.6,
P
< .001) analyses. Primary tumors with VI-RADS ≥ 3 demonstrated significantly shorter RFS (
P = .02) and PFS (
P = .04).
Conclusions
In conclusion, mpMRI with VI-RADS has a high diagnostic value in predicting MIBC in both primary and recurrent BCa. A VI-RADS threshold ≥ 3 is a strong predictor for MIBC, and in primary tumors predicts early recurrence and progression.
Purpose
Our purpose was to evaluate the prognostic value of Vesical Imaging Reporting and Data System (VI-RADS) in bladder cancer (BCa) staging and predicting recurrence or progression.
Methods
We retrospectively analyzed the prospectively collected data from 96 patients with bladder tumors who underwent VI-RADS-based multiparametric magnetic resonance imaging (mpMRI) before endourological treatment from April 2021 to December 2022. Diagnostic performance was evaluated by comparing mpMRI reports with final pathology, using logistic regression for muscle-invasive bladder cancer (MIBC) predictors. Follow-up until May 2023 included Kaplan-Meier and Cox regression analysis to assess VI-RADS predictive roles for recurrence-free survival (RFS) and progression-free survival (PFS).
Results
A total of 96 patients (19.8% women, 80.2% men; median age 68.0 years) were included, with 71% having primary tumors and 29% recurrent BCa. Multiparametric MRI exhibited high sensitivity (92%) and specificity (79%) in predicting MIBC, showing no significant differences between primary and recurrent cancers (AUC: 0.96 vs. 0.92,
P = .565). VI-RADS emerged as a key predictor for MIBC in both univariate (OR: 40.3,
P
< .001) and multivariate (OR: 54.6,
P
< .001) analyses. Primary tumors with VI-RADS ≥ 3 demonstrated significantly shorter RFS (
P = .02) and PFS (
P = .04).
Conclusions
In conclusion, mpMRI with VI-RADS has a high diagnostic value in predicting MIBC in both primary and recurrent BCa. A VI-RADS threshold ≥ 3 is a strong predictor for MIBC, and in primary tumors predicts early recurrence and progression.
Płatkowska, Anna; Słowińska, Monika; Zalewska, Joanna; Swacha, Zbigniew; Szumera-Ciećkiewicz, Anna; Wągrodzki, Michał; Patera, Janusz; Łapieńska-Rey, Katarzyna; Lorent, Małgorzata; Ługowska, Iwona; Rutkowski, Piotr; Owczarek, Witold
In: Journal of Clinical Medicine, vol. 13, no. 15, pp. 4377, 2024, ISSN: 2077-0383.
@article{platkowska_minimally_2024,
title = {Minimally Invasive Plasma Device Management of Multiple Benign Skin Cancers Associated with Rare Genodermatoses—Case Series and Review of the Therapeutic Methods},
author = {Anna Płatkowska and Monika Słowińska and Joanna Zalewska and Zbigniew Swacha and Anna Szumera-Ciećkiewicz and Michał Wągrodzki and Janusz Patera and Katarzyna Łapieńska-Rey and Małgorzata Lorent and Iwona Ługowska and Piotr Rutkowski and Witold Owczarek},
url = {https://www.mdpi.com/2077-0383/13/15/4377},
doi = {10.3390/jcm13154377},
issn = {2077-0383},
year = {2024},
date = {2024-07-01},
urldate = {2024-11-05},
journal = {Journal of Clinical Medicine},
volume = {13},
number = {15},
pages = {4377},
abstract = {Background: Non-melanocytic benign skin tumours encompass a diverse group of lesions, classified based on their cellular origin, such as epidermal, vascular, fibrous, neural, muscle, and adnexal tumours. Though they often reveal solitary lesions, multiple skin tumours focus on genodermatoses. Each syndrome exhibits distinct clinical characteristics and potential complications, including cutaneous and extra-cutaneous malignancies, some of which are potentially life-threatening. Diagnosing genetic syndromes is complex and requires numerous histopathological and immunohistochemistry tests due to similarities between the adnexal tumours and basal cell carcinoma upon pathology. Methods: To illustrate the clinical practice, we conducted a retrospective case study that included eleven patients with genodermatoses referred to a tertiary dermatology clinic from September 2018 to April 2024. We have also conducted a research study on available treatment modalities in this setting. Results: Five patients with excellent aesthetic results were treated using a recently approved FDA plasma device. After searching SCOPUS and PubMed database records, we assessed 96 original articles to present current knowledge regarding the dermato-surgical approach. Conclusions: Multiple skin tumours, especially on the face, may significantly affect patients’ quality of life and have psychological consequences. An appropriate treatment selection tailored to the patient’s needs should be provided. There is no standardised treatment for multiple benign tumours in genodermatoses, and selected methods with varying efficacy are employed. We presented the utility of a new plasma device in these settings.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Background: Non-melanocytic benign skin tumours encompass a diverse group of lesions, classified based on their cellular origin, such as epidermal, vascular, fibrous, neural, muscle, and adnexal tumours. Though they often reveal solitary lesions, multiple skin tumours focus on genodermatoses. Each syndrome exhibits distinct clinical characteristics and potential complications, including cutaneous and extra-cutaneous malignancies, some of which are potentially life-threatening. Diagnosing genetic syndromes is complex and requires numerous histopathological and immunohistochemistry tests due to similarities between the adnexal tumours and basal cell carcinoma upon pathology. Methods: To illustrate the clinical practice, we conducted a retrospective case study that included eleven patients with genodermatoses referred to a tertiary dermatology clinic from September 2018 to April 2024. We have also conducted a research study on available treatment modalities in this setting. Results: Five patients with excellent aesthetic results were treated using a recently approved FDA plasma device. After searching SCOPUS and PubMed database records, we assessed 96 original articles to present current knowledge regarding the dermato-surgical approach. Conclusions: Multiple skin tumours, especially on the face, may significantly affect patients’ quality of life and have psychological consequences. An appropriate treatment selection tailored to the patient’s needs should be provided. There is no standardised treatment for multiple benign tumours in genodermatoses, and selected methods with varying efficacy are employed. We presented the utility of a new plasma device in these settings.
Farah, Raymond; Khamisy-Farah, Rola; Dziedzic, Kacper; Skrzypek, Ewa; Pruc, Michal; Bragazzi, Nicola Luigi; Szarpak, Lukasz; Jomah, Mahmoud
The role of the neutrophil-lymphocyte ratio in predicting poor outcomes in COVID-19 patients Journal Article
In: Cardiology Journal, vol. 31, no. 3, pp. 374–380, 2024, ISSN: 1898-018X, 1897-5593, (Publisher: VM Media Group sp. z o.o).
@article{farah_role_2024,
title = {The role of the neutrophil-lymphocyte ratio in predicting poor outcomes in COVID-19 patients},
author = {Raymond Farah and Rola Khamisy-Farah and Kacper Dziedzic and Ewa Skrzypek and Michal Pruc and Nicola Luigi Bragazzi and Lukasz Szarpak and Mahmoud Jomah},
url = {https://journals.viamedica.pl/cardiology_journal/article/view/98214},
doi = {10.5603/cj.98214},
issn = {1898-018X, 1897-5593},
year = {2024},
date = {2024-06-01},
urldate = {2024-09-17},
journal = {Cardiology Journal},
volume = {31},
number = {3},
pages = {374–380},
note = {Publisher: VM Media Group sp. z o.o},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Wojnar, Marcin; Wierzbiński, Piotr; Samochowiec, Jerzy; Rymaszewska, Joanna; Filipiak, Krzysztof J.; Wichniak, Adam; Mróz, Robert; Mamcarz, Artur; Dudek, Dominika
Management of nicotine dependence in patients with psychiatric disorders – recommendations of the Polish Psychiatric Association – part II Journal Article
In: Psychiatria Polska, vol. 58, no. 3, pp. 419–431, 2024, ISSN: 0033-2674, 2391-5854.
@article{wojnar_management_2024,
title = {Management of nicotine dependence in patients with psychiatric disorders – recommendations of the Polish Psychiatric Association – part II},
author = {Marcin Wojnar and Piotr Wierzbiński and Jerzy Samochowiec and Joanna Rymaszewska and Krzysztof J. Filipiak and Adam Wichniak and Robert Mróz and Artur Mamcarz and Dominika Dudek},
url = {https://www.psychiatriapolska.pl/Management-of-nicotine-dependence-in-patients-with-psychiatric-disorders-recommendations,161774,0,2.html},
doi = {10.12740/PP/OnlineFirst/161774},
issn = {0033-2674, 2391-5854},
year = {2024},
date = {2024-06-01},
urldate = {2024-10-28},
journal = {Psychiatria Polska},
volume = {58},
number = {3},
pages = {419–431},
abstract = {Rozwój metod leczenia uzależnienia od nikotyny postępuje powoli, gdyż osoby z zaburzeniami psychicznymi są zazwyczaj wykluczane z udziału w badaniach klinicznych. Istnieje szereg możliwości terapeutycznych wspomagania rzucenia palenia, obejmujących interwencje psychologiczne i farmakologiczne, które powinny być oferowane osobom z zaburzeniami psychicznymi palącymi papierosy. Pierwszym krokiem w pomaganiu osobom palącym wyroby tytoniowe i uzależnionym od nikotyny jest ocena intensywności palenia tytoniu i potwierdzenie uzależnienia od nikotyny. Aktualnie dysponujemy kilkoma formami metod leczenia uzależnienia od nikotyny – od edukacji, psychoterapii poprzez farmakoterapię i terapię zastępczą po uzyskanie stopniowych postępów z zastosowaniem metody redukcji szkód. W leczeniu farmakologicznym uzależnienia od nikotyny można wybrać nikotynową terapię zastępczą, wareniklinę lub bupropion. Zwiększenie skuteczności może być osiągnięte poprzez prowadzenie terapii antynikotynowej w ramach leczenia psychiatrycznego oraz promocji redukcji szkód jako akceptowalnego wyjściowego celu terapeutycznego. Strategia redukcji szkód jest podejściem do rozważenia indywidualnie, szczególnie w przypadku osób niezdolnych do zaprzestania palenia papierosów, pacjentów z ograniczonym wglądem chorobowym, pacjentów w zaostrzeniu choroby oraz uporczywie niewspółpracujących. W pracy przedstawiono zalecenia Polskiego Towarzystwa Psychiatrycznego odnośnie diagnostyki oraz różnych metod leczenia uzależnienia od nikotyny u pacjentów z zaburzeniami psychicznymi.
,
The development of treatment methods for nicotine dependence has progressed slowly because people with psychiatric disorders are usually excluded from participating in clinical trials. There are several therapeutic options to support smoking cessation, including psychological and pharmacological interventions, which should be offered to smokers with mental disorders. The first step in helping tobacco smokers and nicotine-dependent individuals is the assessment of smoking intensity and confirmation of nicotine dependence. Currently, we have several methods of treating nicotine dependence – starting from education and psychotherapy, through pharmacotherapy and replacement therapy, and ending up with obtaining gradual progress with the application of harm reduction. Pharmacological treatment options include nicotine replacement therapy, varenicline or bupropion. The effectiveness of such interventions can be improved by providing anti-smoking therapy under psychiatric treatment and promoting harm reduction as an acceptable initial therapeutic goal. The harm reduction strategy is an approach that should be taken into account individually, particularly in the case of individuals unable to stop smoking, patients with limited insight into their illness, patients experiencing an exacerbation of their illness and persistently uncooperative patients. In this paper, recommendations of the Polish Psychiatric Association on the diagnostics and different treatment methods for nicotine dependence in patients with psychiatric disorders are presented.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Rozwój metod leczenia uzależnienia od nikotyny postępuje powoli, gdyż osoby z zaburzeniami psychicznymi są zazwyczaj wykluczane z udziału w badaniach klinicznych. Istnieje szereg możliwości terapeutycznych wspomagania rzucenia palenia, obejmujących interwencje psychologiczne i farmakologiczne, które powinny być oferowane osobom z zaburzeniami psychicznymi palącymi papierosy. Pierwszym krokiem w pomaganiu osobom palącym wyroby tytoniowe i uzależnionym od nikotyny jest ocena intensywności palenia tytoniu i potwierdzenie uzależnienia od nikotyny. Aktualnie dysponujemy kilkoma formami metod leczenia uzależnienia od nikotyny – od edukacji, psychoterapii poprzez farmakoterapię i terapię zastępczą po uzyskanie stopniowych postępów z zastosowaniem metody redukcji szkód. W leczeniu farmakologicznym uzależnienia od nikotyny można wybrać nikotynową terapię zastępczą, wareniklinę lub bupropion. Zwiększenie skuteczności może być osiągnięte poprzez prowadzenie terapii antynikotynowej w ramach leczenia psychiatrycznego oraz promocji redukcji szkód jako akceptowalnego wyjściowego celu terapeutycznego. Strategia redukcji szkód jest podejściem do rozważenia indywidualnie, szczególnie w przypadku osób niezdolnych do zaprzestania palenia papierosów, pacjentów z ograniczonym wglądem chorobowym, pacjentów w zaostrzeniu choroby oraz uporczywie niewspółpracujących. W pracy przedstawiono zalecenia Polskiego Towarzystwa Psychiatrycznego odnośnie diagnostyki oraz różnych metod leczenia uzależnienia od nikotyny u pacjentów z zaburzeniami psychicznymi.
,
The development of treatment methods for nicotine dependence has progressed slowly because people with psychiatric disorders are usually excluded from participating in clinical trials. There are several therapeutic options to support smoking cessation, including psychological and pharmacological interventions, which should be offered to smokers with mental disorders. The first step in helping tobacco smokers and nicotine-dependent individuals is the assessment of smoking intensity and confirmation of nicotine dependence. Currently, we have several methods of treating nicotine dependence – starting from education and psychotherapy, through pharmacotherapy and replacement therapy, and ending up with obtaining gradual progress with the application of harm reduction. Pharmacological treatment options include nicotine replacement therapy, varenicline or bupropion. The effectiveness of such interventions can be improved by providing anti-smoking therapy under psychiatric treatment and promoting harm reduction as an acceptable initial therapeutic goal. The harm reduction strategy is an approach that should be taken into account individually, particularly in the case of individuals unable to stop smoking, patients with limited insight into their illness, patients experiencing an exacerbation of their illness and persistently uncooperative patients. In this paper, recommendations of the Polish Psychiatric Association on the diagnostics and different treatment methods for nicotine dependence in patients with psychiatric disorders are presented.
,
The development of treatment methods for nicotine dependence has progressed slowly because people with psychiatric disorders are usually excluded from participating in clinical trials. There are several therapeutic options to support smoking cessation, including psychological and pharmacological interventions, which should be offered to smokers with mental disorders. The first step in helping tobacco smokers and nicotine-dependent individuals is the assessment of smoking intensity and confirmation of nicotine dependence. Currently, we have several methods of treating nicotine dependence – starting from education and psychotherapy, through pharmacotherapy and replacement therapy, and ending up with obtaining gradual progress with the application of harm reduction. Pharmacological treatment options include nicotine replacement therapy, varenicline or bupropion. The effectiveness of such interventions can be improved by providing anti-smoking therapy under psychiatric treatment and promoting harm reduction as an acceptable initial therapeutic goal. The harm reduction strategy is an approach that should be taken into account individually, particularly in the case of individuals unable to stop smoking, patients with limited insight into their illness, patients experiencing an exacerbation of their illness and persistently uncooperative patients. In this paper, recommendations of the Polish Psychiatric Association on the diagnostics and different treatment methods for nicotine dependence in patients with psychiatric disorders are presented.
Charpidou, Andriani; Hardavella, Georgia; Boutsikou, Efimia; Panagiotou, Emmanouil; Simsek, Gökçen Ömeroğlu; Verbeke, Koen; Xhemalaj, Daniela; Domagała-Kulawik, Joanna
Unravelling the diagnostic pathology and molecular biomarkers in lung cancer Journal Article
In: Breathe, vol. 20, no. 2, pp. 230192, 2024, ISSN: 1810-6838, 2073-4735.
@article{charpidou_unravelling_2024,
title = {Unravelling the diagnostic pathology and molecular biomarkers in lung cancer},
author = {Andriani Charpidou and Georgia Hardavella and Efimia Boutsikou and Emmanouil Panagiotou and Gökçen Ömeroğlu Simsek and Koen Verbeke and Daniela Xhemalaj and Joanna Domagała-Kulawik},
url = {http://publications.ersnet.org/lookup/doi/10.1183/20734735.0192-2023},
doi = {10.1183/20734735.0192-2023},
issn = {1810-6838, 2073-4735},
year = {2024},
date = {2024-06-01},
urldate = {2024-10-28},
journal = {Breathe},
volume = {20},
number = {2},
pages = {230192},
abstract = {The progress in lung cancer treatment is closely interlinked with the progress in diagnostic methods. There are four steps before commencing lung cancer treatment: estimation of the patient's performance status, assessment of disease stage (tumour, node, metastasis), recognition of histological subtype, and detection of biomarkers. The resection rate in lung cancer is <30% and >70% of patients need systemic therapy, which is individually adjusted. Accurate histological diagnosis is very important and it is the basis of further molecular diagnosis. In many cases only small biopsy samples are available and the rules for their assessment are defined in this review. The use of immunochemistry with at least thyroid transcription factor 1 (TTF1) and p40 is decisive in distinction between lung adenocarcinoma and squamous cell carcinoma. Molecular diagnosis and detection of known driver mutations is necessary for introducing targeted therapy and use of multiplex gene panel assays using next-generation sequencing is recommended. Immunotherapy with checkpoint inhibitors is the second promising method of systemic therapy with best results in tumours with high programmed death-ligand 1 (PD-L1) expression on cancer cells. Finally, the determination of a full tumour pattern will be possible using artificial intelligence in the near future.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
The progress in lung cancer treatment is closely interlinked with the progress in diagnostic methods. There are four steps before commencing lung cancer treatment: estimation of the patient's performance status, assessment of disease stage (tumour, node, metastasis), recognition of histological subtype, and detection of biomarkers. The resection rate in lung cancer is <30% and >70% of patients need systemic therapy, which is individually adjusted. Accurate histological diagnosis is very important and it is the basis of further molecular diagnosis. In many cases only small biopsy samples are available and the rules for their assessment are defined in this review. The use of immunochemistry with at least thyroid transcription factor 1 (TTF1) and p40 is decisive in distinction between lung adenocarcinoma and squamous cell carcinoma. Molecular diagnosis and detection of known driver mutations is necessary for introducing targeted therapy and use of multiplex gene panel assays using next-generation sequencing is recommended. Immunotherapy with checkpoint inhibitors is the second promising method of systemic therapy with best results in tumours with high programmed death-ligand 1 (PD-L1) expression on cancer cells. Finally, the determination of a full tumour pattern will be possible using artificial intelligence in the near future.
Lipiński, Patryk; Tylki-Szymańska, Anna
The Liver and Lysosomal Storage Diseases: From Pathophysiology to Clinical Presentation, Diagnostics, and Treatment Journal Article
In: Diagnostics, vol. 14, no. 12, pp. 1299, 2024, ISSN: 2075-4418.
@article{lipinski_liver_2024,
title = {The Liver and Lysosomal Storage Diseases: From Pathophysiology to Clinical Presentation, Diagnostics, and Treatment},
author = {Patryk Lipiński and Anna Tylki-Szymańska},
url = {https://www.mdpi.com/2075-4418/14/12/1299},
doi = {10.3390/diagnostics14121299},
issn = {2075-4418},
year = {2024},
date = {2024-06-01},
urldate = {2024-10-28},
journal = {Diagnostics},
volume = {14},
number = {12},
pages = {1299},
abstract = {The liver, given its role as the central metabolic organ, is involved in many inherited metabolic disorders, including lysosomal storage diseases (LSDs). The aim of this manuscript was to provide a comprehensive overview on liver involvement in LSDs, focusing on clinical manifestation and its pathomechanisms. Gaucher disease, acid sphingomyelinase deficiency, and lysosomal acid lipase deficiency were thoroughly reviewed, with hepatic manifestation being a dominant clinical phenotype. The natural history of liver disease in the above-mentioned lysosomal disorders was delineated. The importance of Niemann–Pick type C disease as a cause of cholestatic jaundice, preceding neurological manifestation, was also highlighted. Diagnostic methods and current therapeutic management of LSDs were also discussed in the context of liver involvement.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
The liver, given its role as the central metabolic organ, is involved in many inherited metabolic disorders, including lysosomal storage diseases (LSDs). The aim of this manuscript was to provide a comprehensive overview on liver involvement in LSDs, focusing on clinical manifestation and its pathomechanisms. Gaucher disease, acid sphingomyelinase deficiency, and lysosomal acid lipase deficiency were thoroughly reviewed, with hepatic manifestation being a dominant clinical phenotype. The natural history of liver disease in the above-mentioned lysosomal disorders was delineated. The importance of Niemann–Pick type C disease as a cause of cholestatic jaundice, preceding neurological manifestation, was also highlighted. Diagnostic methods and current therapeutic management of LSDs were also discussed in the context of liver involvement.
Wojnar, Marcin; Wierzbiński, Piotr; Samochowiec, Jerzy; Rymaszewska, Joanna; Filipiak, Krzysztof J.; Wichniak, Adam; Mróz, Robert; Mamcarz, Artur; Dudek, Dominika
Management of nicotine dependence in patients with psychiatric disorders – recommendations of the Polish Psychiatric Association – part I Journal Article
In: Psychiatria Polska, vol. 58, no. 3, pp. 403–418, 2024, ISSN: 0033-2674, 2391-5854.
@article{wojnar_management_2024-1,
title = {Management of nicotine dependence in patients with psychiatric disorders – recommendations of the Polish Psychiatric Association – part I},
author = {Marcin Wojnar and Piotr Wierzbiński and Jerzy Samochowiec and Joanna Rymaszewska and Krzysztof J. Filipiak and Adam Wichniak and Robert Mróz and Artur Mamcarz and Dominika Dudek},
url = {https://www.psychiatriapolska.pl/Management-of-nicotine-dependence-in-patients-with-psychiatric-disorders-recommendations,161773,0,2.html},
doi = {10.12740/PP/OnlineFirst/161773},
issn = {0033-2674, 2391-5854},
year = {2024},
date = {2024-06-01},
urldate = {2024-10-28},
journal = {Psychiatria Polska},
volume = {58},
number = {3},
pages = {403–418},
abstract = {Palenie tytoniu i uzależnienie od nikotyny są nadal jedną z głównych przyczyn szeregu poważnych i skracających życie schorzeń somatycznych. Jednocześnie są bardziej rozpowszechnione u chorych psychicznie niż w populacji ogólnej. W niniejszej pracy, która stanowi część pierwszą rekomendacji Polskiego Towarzystwa Psychiatrycznego, przedstawiono skalę zjawiska w populacji ogólnej i wśród osób z zaburzeniami psychicznymi, kryteria rozpoznawania uzależnienia i zespołu abstynencyjnego. Omówiono wpływ palenia tytoniu i ekspozycji na dym tytoniowy na rozwój i przebieg zaburzeń psychicznych, a także na przebieg leczenia zaburzeń psychicznych, w tym interakcje nikotyny z lekami psychotropowymi. Wielu pacjentów z zaburzeniami psychicznymi jest w stanie ograniczyć palenie lub uzyskać całkowitą abstynencję, jeśli zaoferuje im się adekwatną pomoc terapeutyczną. Wbrew powszechnej opinii, zaprzestanie palenia tytoniu i leczenie uzależnienia od nikotyny nie wpływa negatywnie na objawy zaburzeń psychicznych; stan psychiczny pacjentów może ulegać poprawie w efekcie terapii antynikotynowej. Najlepsze efekty pod względem utrzymania abstynencji daje zintegrowane z leczeniem psychiatrycznym podejście łączące farmakoterapię z interwencją psychoterapeutyczną.
,
Smoking and nicotine dependence are still one of the main reasons for a number of serious and life-shortening somatic diseases. At the same time, they are more prevalent in mentally ill individuals than in the general population. This work, which constitutes the first part of recommendations of the Polish Psychiatric Association, presents the scale of the phenomenon in the general population and among people with psychiatric disorders, diagnostic criteria of nicotine dependence and nicotine withdrawal. It discusses the impact of smoking and exposure to cigarette smoke on the development and course of psychiatric disorders as well as on the treatment of psychiatric disorders, including interactions between nicotine and psychotropic medications. Many psychiatric patients can reduce smoking or achieve complete abstinence if they are offered adequate motivation and therapeutic support. Contrary to popular belief, smoking cessation and nicotine dependence treatment do not negatively affect the symptoms of psychiatric disorders; patients’ mental conditions can improve following smoking cessation therapy. The best results in terms of maintaining abstinence are achieved with a treatment approach that combines pharmacotherapy with psychotherapeutic intervention integrated into routine psychiatric care.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Palenie tytoniu i uzależnienie od nikotyny są nadal jedną z głównych przyczyn szeregu poważnych i skracających życie schorzeń somatycznych. Jednocześnie są bardziej rozpowszechnione u chorych psychicznie niż w populacji ogólnej. W niniejszej pracy, która stanowi część pierwszą rekomendacji Polskiego Towarzystwa Psychiatrycznego, przedstawiono skalę zjawiska w populacji ogólnej i wśród osób z zaburzeniami psychicznymi, kryteria rozpoznawania uzależnienia i zespołu abstynencyjnego. Omówiono wpływ palenia tytoniu i ekspozycji na dym tytoniowy na rozwój i przebieg zaburzeń psychicznych, a także na przebieg leczenia zaburzeń psychicznych, w tym interakcje nikotyny z lekami psychotropowymi. Wielu pacjentów z zaburzeniami psychicznymi jest w stanie ograniczyć palenie lub uzyskać całkowitą abstynencję, jeśli zaoferuje im się adekwatną pomoc terapeutyczną. Wbrew powszechnej opinii, zaprzestanie palenia tytoniu i leczenie uzależnienia od nikotyny nie wpływa negatywnie na objawy zaburzeń psychicznych; stan psychiczny pacjentów może ulegać poprawie w efekcie terapii antynikotynowej. Najlepsze efekty pod względem utrzymania abstynencji daje zintegrowane z leczeniem psychiatrycznym podejście łączące farmakoterapię z interwencją psychoterapeutyczną.
,
Smoking and nicotine dependence are still one of the main reasons for a number of serious and life-shortening somatic diseases. At the same time, they are more prevalent in mentally ill individuals than in the general population. This work, which constitutes the first part of recommendations of the Polish Psychiatric Association, presents the scale of the phenomenon in the general population and among people with psychiatric disorders, diagnostic criteria of nicotine dependence and nicotine withdrawal. It discusses the impact of smoking and exposure to cigarette smoke on the development and course of psychiatric disorders as well as on the treatment of psychiatric disorders, including interactions between nicotine and psychotropic medications. Many psychiatric patients can reduce smoking or achieve complete abstinence if they are offered adequate motivation and therapeutic support. Contrary to popular belief, smoking cessation and nicotine dependence treatment do not negatively affect the symptoms of psychiatric disorders; patients’ mental conditions can improve following smoking cessation therapy. The best results in terms of maintaining abstinence are achieved with a treatment approach that combines pharmacotherapy with psychotherapeutic intervention integrated into routine psychiatric care.
,
Smoking and nicotine dependence are still one of the main reasons for a number of serious and life-shortening somatic diseases. At the same time, they are more prevalent in mentally ill individuals than in the general population. This work, which constitutes the first part of recommendations of the Polish Psychiatric Association, presents the scale of the phenomenon in the general population and among people with psychiatric disorders, diagnostic criteria of nicotine dependence and nicotine withdrawal. It discusses the impact of smoking and exposure to cigarette smoke on the development and course of psychiatric disorders as well as on the treatment of psychiatric disorders, including interactions between nicotine and psychotropic medications. Many psychiatric patients can reduce smoking or achieve complete abstinence if they are offered adequate motivation and therapeutic support. Contrary to popular belief, smoking cessation and nicotine dependence treatment do not negatively affect the symptoms of psychiatric disorders; patients’ mental conditions can improve following smoking cessation therapy. The best results in terms of maintaining abstinence are achieved with a treatment approach that combines pharmacotherapy with psychotherapeutic intervention integrated into routine psychiatric care.
Pecold, Jaroslaw; Krupowies, Maciej; Pruc, Michal; Tomaszewski, Marcin; Szarpak, Lukasz; Swieczkowski, Damian; Koselak, Maciej; Bragazzi, Nicola Luigi; Al-Jeabory, Mahdi
The use of tranexamic acid in patients submitted to primary total hip and knee arthroplasty: a single-center retrospective observational study Journal Article
In: Medical Research Journal, vol. 9, no. 2, pp. 180–186, 2024, ISSN: 2451-4101, 2451-2591.
@article{pecold_use_2024,
title = {The use of tranexamic acid in patients submitted to primary total hip and knee arthroplasty: a single-center retrospective observational study},
author = {Jaroslaw Pecold and Maciej Krupowies and Michal Pruc and Marcin Tomaszewski and Lukasz Szarpak and Damian Swieczkowski and Maciej Koselak and Nicola Luigi Bragazzi and Mahdi Al-Jeabory},
url = {https://journals.viamedica.pl/medical_research_journal/article/view/99367},
doi = {10.5603/mrj.99367},
issn = {2451-4101, 2451-2591},
year = {2024},
date = {2024-06-01},
urldate = {2024-11-03},
journal = {Medical Research Journal},
volume = {9},
number = {2},
pages = {180–186},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Wilimski, Radosław; Budzianowski, Jan; Łomiak, Michał; Olasińska-Wiśniewska, Anna; Pieniak, Katarzyna; Jędrzejczyk, Szymon; Domaszk, Olaf; Chudzik, Magdalena; Filipiak, Krzysztof J.; Hiczkiewicz, Jarosław; Faron, Wojciech; Urbanowicz, Tomasz; Jemielity, Marek; Grygier, Marek; Grabowski, Marcin; Kuśmierczyk, Mariusz; Rymuza, Bartosz; Huczek, Zenon; Kochman, Janusz; Pol, Edwin Van Der; Nieuwland, Rienk; Gąsecka, Aleksandra
Extracellular Vesicles to Predict Outcomes After Transcatheter Aortic Valve Implantation – a Prospective, Multicenter Cohort Study Journal Article
In: Journal of Cardiovascular Translational Research, 2024, ISSN: 1937-5387, 1937-5395.
@article{wilimski_extracellular_2024,
title = {Extracellular Vesicles to Predict Outcomes After Transcatheter Aortic Valve Implantation – a Prospective, Multicenter Cohort Study},
author = {Radosław Wilimski and Jan Budzianowski and Michał Łomiak and Anna Olasińska-Wiśniewska and Katarzyna Pieniak and Szymon Jędrzejczyk and Olaf Domaszk and Magdalena Chudzik and Krzysztof J. Filipiak and Jarosław Hiczkiewicz and Wojciech Faron and Tomasz Urbanowicz and Marek Jemielity and Marek Grygier and Marcin Grabowski and Mariusz Kuśmierczyk and Bartosz Rymuza and Zenon Huczek and Janusz Kochman and Edwin Van Der Pol and Rienk Nieuwland and Aleksandra Gąsecka},
url = {https://link.springer.com/10.1007/s12265-024-10521-x},
doi = {10.1007/s12265-024-10521-x},
issn = {1937-5387, 1937-5395},
year = {2024},
date = {2024-05-01},
urldate = {2024-10-28},
journal = {Journal of Cardiovascular Translational Research},
abstract = {Abstract
Introduction
Transcatheter aortic valve implantation (TAVI) is an established treatment for aortic stenosis (AS) in patients at intermediate and high surgical risk. Circulating extracellular vesicles (EVs) are nanoparticles involved in cardiovascular diseases. We aimed to (i) determine the effect of TAVI on plasma concentrations of five EV subtypes and (ii) evaluate the predictive value of EVs for post-TAVI outcomes.
Methods
Blood samples were collected 1 day before TAVI and at hospital discharge. Concentrations of EVs were evaluated using flow cytometry.
Results Concentration of leukocytes EVs decreased after TAVI, compared to the measurement before (p = 0.008). Among 123 patients discharged from the hospital, 19.5% experienced MACCE during the median of 10.3 months. Increased pre-TAVI concentration of phosphatidylserine-exposing EVs was an independent predictor of MACCE in multivariable analysis (OR 5.313, 95% CI 1.164–24.258},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Abstract
Introduction
Transcatheter aortic valve implantation (TAVI) is an established treatment for aortic stenosis (AS) in patients at intermediate and high surgical risk. Circulating extracellular vesicles (EVs) are nanoparticles involved in cardiovascular diseases. We aimed to (i) determine the effect of TAVI on plasma concentrations of five EV subtypes and (ii) evaluate the predictive value of EVs for post-TAVI outcomes.
Methods
Blood samples were collected 1 day before TAVI and at hospital discharge. Concentrations of EVs were evaluated using flow cytometry.
Results Concentration of leukocytes EVs decreased after TAVI, compared to the measurement before (p = 0.008). Among 123 patients discharged from the hospital, 19.5% experienced MACCE during the median of 10.3 months. Increased pre-TAVI concentration of phosphatidylserine-exposing EVs was an independent predictor of MACCE in multivariable analysis (OR 5.313, 95% CI 1.164–24.258
Introduction
Transcatheter aortic valve implantation (TAVI) is an established treatment for aortic stenosis (AS) in patients at intermediate and high surgical risk. Circulating extracellular vesicles (EVs) are nanoparticles involved in cardiovascular diseases. We aimed to (i) determine the effect of TAVI on plasma concentrations of five EV subtypes and (ii) evaluate the predictive value of EVs for post-TAVI outcomes.
Methods
Blood samples were collected 1 day before TAVI and at hospital discharge. Concentrations of EVs were evaluated using flow cytometry.
Results Concentration of leukocytes EVs decreased after TAVI, compared to the measurement before (p = 0.008). Among 123 patients discharged from the hospital, 19.5% experienced MACCE during the median of 10.3 months. Increased pre-TAVI concentration of phosphatidylserine-exposing EVs was an independent predictor of MACCE in multivariable analysis (OR 5.313, 95% CI 1.164–24.258
Cios, Aleksandra; Ciepielak, Martyna; Lieto, Krystyna; Matak, Damian; Lewicki, Sławomir; Palusińska, Małgorzata; Stankiewicz, Wanda; Szymański, Łukasz
In: Medycyna Pracy, vol. 75, no. 2, pp. 133–141, 2024, ISSN: 0465-5893, 2353-1339.
@article{cios_extremely_2024,
title = {Extremely low-frequency electromagnetic field (ELF-EMF) induced alterations in gene expression and cytokine secretion in clear cell renal carcinoma cells},
author = {Aleksandra Cios and Martyna Ciepielak and Krystyna Lieto and Damian Matak and Sławomir Lewicki and Małgorzata Palusińska and Wanda Stankiewicz and Łukasz Szymański},
url = {https://medpr.imp.lodz.pl/Extremely-low-frequency-electromagnetic-field-ELF-EMF-induced-alterations-in-gene,186834,0,2.html},
doi = {10.13075/mp.5893.01476},
issn = {0465-5893, 2353-1339},
year = {2024},
date = {2024-05-01},
urldate = {2024-10-28},
journal = {Medycyna Pracy},
volume = {75},
number = {2},
pages = {133–141},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Pietrasik, Arkadiusz; Kurzyna, Paweł; Szwed, Piotr; Jasińska-Gniadzik, Karolina; Gąsecka, Aleksandra; Darocha, Szymona; Zieliński, Dariusz; Szarpak, Łukasz; Kochman, Janusz; Grabowski, Marcin; Opolski, Grzegorz; Torbicki, Adam; Kurzyna, Marcin
Treatment of high- and intermediate-high-risk pulmonary embolism by the Pulmonary Embolism Response Team: Focus on catheter-directed therapies Journal Article
In: Cardiology Journal, vol. 31, no. 2, pp. 215–225, 2024, ISSN: 1898-018X, 1897-5593, (Publisher: VM Media Group sp. z o.o).
@article{pietrasik_treatment_2024,
title = {Treatment of high- and intermediate-high-risk pulmonary embolism by the Pulmonary Embolism Response Team: Focus on catheter-directed therapies},
author = {Arkadiusz Pietrasik and Paweł Kurzyna and Piotr Szwed and Karolina Jasińska-Gniadzik and Aleksandra Gąsecka and Szymona Darocha and Dariusz Zieliński and Łukasz Szarpak and Janusz Kochman and Marcin Grabowski and Grzegorz Opolski and Adam Torbicki and Marcin Kurzyna},
url = {https://journals.viamedica.pl/cardiology_journal/article/view/95272},
doi = {10.5603/cj.a2023.0047},
issn = {1898-018X, 1897-5593},
year = {2024},
date = {2024-04-01},
urldate = {2024-09-17},
journal = {Cardiology Journal},
volume = {31},
number = {2},
pages = {215–225},
note = {Publisher: VM Media Group sp. z o.o},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Karbowska, Eryka; Swieczkowski, Damian; Gasecka, Aleksandra; Pruc, Michal; Safiejko, Kamil; Ladny, Jerzy R.; Kopiec, Tomasz; Jaguszewski, Milosz J.; Filipiak, Krzysztof J.; Rafique, Zubaid; Szarpak, Lukasz
Statins and the risk of pancreatic cancer: A systematic review and meta-analysis of 2,797,186 patients Journal Article
In: Cardiology Journal, vol. 31, no. 2, pp. 243–250, 2024, ISSN: 1898-018X, 1897-5593, (Publisher: VM Media Group sp. z o.o).
@article{karbowska_statins_2024,
title = {Statins and the risk of pancreatic cancer: A systematic review and meta-analysis of 2,797,186 patients},
author = {Eryka Karbowska and Damian Swieczkowski and Aleksandra Gasecka and Michal Pruc and Kamil Safiejko and Jerzy R. Ladny and Tomasz Kopiec and Milosz J. Jaguszewski and Krzysztof J. Filipiak and Zubaid Rafique and Lukasz Szarpak},
url = {https://journals.viamedica.pl/cardiology_journal/article/view/88590},
doi = {10.5603/cj.a2022.0014},
issn = {1898-018X, 1897-5593},
year = {2024},
date = {2024-04-01},
urldate = {2024-09-17},
journal = {Cardiology Journal},
volume = {31},
number = {2},
pages = {243–250},
note = {Publisher: VM Media Group sp. z o.o},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Urbanowicz, Tomasz; Rajewska-Tabor, Justyna; Olasińska-Wiśniewska, Anna; Filipiak, Krzysztof J.; Michalak, Michał; Rzesoś, Patrycja; Szot, Mateusz; Krasińska-Płachta, Aleksandra; Krasińska, Beata; Pyda, Małgorzata; Tykarski, Andrzej; Jemielity, Marek; Krasiński, Zbigniew
Demographical and Clinical Factors Predictive for Aortic Dilatation. When should we be Concerned about the Size? Journal Article
In: Reviews in Cardiovascular Medicine, vol. 25, no. 5, pp. 150, 2024, ISSN: 1530-6550.
@article{urbanowicz_demographical_2024,
title = {Demographical and Clinical Factors Predictive for Aortic Dilatation. When should we be Concerned about the Size?},
author = {Tomasz Urbanowicz and Justyna Rajewska-Tabor and Anna Olasińska-Wiśniewska and Krzysztof J. Filipiak and Michał Michalak and Patrycja Rzesoś and Mateusz Szot and Aleksandra Krasińska-Płachta and Beata Krasińska and Małgorzata Pyda and Andrzej Tykarski and Marek Jemielity and Zbigniew Krasiński},
url = {https://www.imrpress.com/journal/RCM/25/5/10.31083/j.rcm2505150},
doi = {10.31083/j.rcm2505150},
issn = {1530-6550},
year = {2024},
date = {2024-04-01},
urldate = {2024-10-28},
journal = {Reviews in Cardiovascular Medicine},
volume = {25},
number = {5},
pages = {150},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Urbanowicz, Tomasz; Hanć, Anetta; Tomczak, Jolanta; Michalak, Michał; Olasińska-Wiśniewska, Anna; Rzesoś, Patrycja; Szot, Mateusz; Filipiak, Krzysztof J.; Krasińska, Beata; Krasiński, Zbigniew; Tykarski, Andrzej; Jemielity, Marek
The Protective Effect of the Crosstalk between Zinc Hair Concentration and Lymphocyte Count—Preliminary Report Journal Article
In: Life, vol. 14, no. 5, pp. 571, 2024, ISSN: 2075-1729.
@article{urbanowicz_protective_2024,
title = {The Protective Effect of the Crosstalk between Zinc Hair Concentration and Lymphocyte Count—Preliminary Report},
author = {Tomasz Urbanowicz and Anetta Hanć and Jolanta Tomczak and Michał Michalak and Anna Olasińska-Wiśniewska and Patrycja Rzesoś and Mateusz Szot and Krzysztof J. Filipiak and Beata Krasińska and Zbigniew Krasiński and Andrzej Tykarski and Marek Jemielity},
url = {https://www.mdpi.com/2075-1729/14/5/571},
doi = {10.3390/life14050571},
issn = {2075-1729},
year = {2024},
date = {2024-04-01},
urldate = {2024-10-28},
journal = {Life},
volume = {14},
number = {5},
pages = {571},
abstract = {Background: An imbalance between pro- and anti-inflammatory mechanisms is indicated in the pathophysiology of atherosclerotic plaque. The coronary artery and carotid disease, despite sharing similar risk factors, are developed separately. The aim of this study was to analyze possible mechanisms between trace element hair–scalp concentrations and whole blood counts that favor atherosclerotic plaque progression in certain locations. Methods: There were 65 (36 (55%) males and 29 (45%) females) patients with a median age of 68 (61–73) years enrolled in a prospective, preliminary, multicenter analysis. The study group was composed of 13 patients with stable coronary artery disease (CAD group) referred for surgical revascularization due to multivessel coronary disease, 34 patients with carotid artery disease (carotid group) admitted for vascular procedure, and 18 patients in a control group (control group). Results: There was a significant difference between the CAD and carotid groups regarding lymphocyte (p = 0.004) counts. The biochemical comparison between the coronary and carotid groups revealed significant differences regarding chromium (Cr) (p = 0.002), copper (Cu) (p < 0.001), and zinc (Zn) (p < 0.001) concentrations. Spearman Rank Order Correlations between lymphocyte counts and trace elements in the analyzed groups were performed, revealing a strong correlation with zinc (R = 0.733, p < 0.001) in the control group (non-CAD, non-carotid). Conclusion: Significant differences in hair–scalp concentrations related to atherosclerosis location were observed in our analysis. The interplay between zinc concentration and lymphocyte count may play a pivotal role in cardiovascular disease development.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Background: An imbalance between pro- and anti-inflammatory mechanisms is indicated in the pathophysiology of atherosclerotic plaque. The coronary artery and carotid disease, despite sharing similar risk factors, are developed separately. The aim of this study was to analyze possible mechanisms between trace element hair–scalp concentrations and whole blood counts that favor atherosclerotic plaque progression in certain locations. Methods: There were 65 (36 (55%) males and 29 (45%) females) patients with a median age of 68 (61–73) years enrolled in a prospective, preliminary, multicenter analysis. The study group was composed of 13 patients with stable coronary artery disease (CAD group) referred for surgical revascularization due to multivessel coronary disease, 34 patients with carotid artery disease (carotid group) admitted for vascular procedure, and 18 patients in a control group (control group). Results: There was a significant difference between the CAD and carotid groups regarding lymphocyte (p = 0.004) counts. The biochemical comparison between the coronary and carotid groups revealed significant differences regarding chromium (Cr) (p = 0.002), copper (Cu) (p < 0.001), and zinc (Zn) (p < 0.001) concentrations. Spearman Rank Order Correlations between lymphocyte counts and trace elements in the analyzed groups were performed, revealing a strong correlation with zinc (R = 0.733, p < 0.001) in the control group (non-CAD, non-carotid). Conclusion: Significant differences in hair–scalp concentrations related to atherosclerosis location were observed in our analysis. The interplay between zinc concentration and lymphocyte count may play a pivotal role in cardiovascular disease development.
Safiejko, Kamil; Pedziwiatr, Michal; Pruc, Michal; Tarkowski, Radoslaw; Juchimiuk, Marcin; Domurat, Marian; Smereka, Jacek; Anvarov, Khikmat; Sielicki, Przemyslaw; Kurek, Krzysztof; Szarpak, Lukasz
Robotic versus Laparoscopic Liver Resections for Colorectal Metastases: A Systematic Review and Meta-Analysis Journal Article
In: Cancers, vol. 16, no. 8, pp. 1596, 2024, ISSN: 2072-6694.
@article{safiejko_robotic_2024,
title = {Robotic versus Laparoscopic Liver Resections for Colorectal Metastases: A Systematic Review and Meta-Analysis},
author = {Kamil Safiejko and Michal Pedziwiatr and Michal Pruc and Radoslaw Tarkowski and Marcin Juchimiuk and Marian Domurat and Jacek Smereka and Khikmat Anvarov and Przemyslaw Sielicki and Krzysztof Kurek and Lukasz Szarpak},
url = {https://www.mdpi.com/2072-6694/16/8/1596},
doi = {10.3390/cancers16081596},
issn = {2072-6694},
year = {2024},
date = {2024-04-01},
urldate = {2024-10-28},
journal = {Cancers},
volume = {16},
number = {8},
pages = {1596},
abstract = {Colorectal cancer is the third most common cancer worldwide, and the liver is the most common localization of metastatic disease. The incidence of minimally invasive liver surgery is increasing, and robotic surgery (RLR) is believed to overcome some limitations of a laparoscopic approach (LRL). We performed a systematic review and meta-analysis of operative and short-term oncologic outcomes of the laparoscopic versus robotic-assisted liver resection for colorectal liver metastases. An online search of PubMed, Embase, Scopus, and the Cochrane databases was performed. Eight studies involving 3210 patients were considered eligible for the meta-analysis. In the LRL group, a higher conversion to open rate (12.4%) was observed compared to the RLR (6.7%; p = <0.001). 30-day mortality was 0.7% for the LRL group compared to 0.5% for the RLR group (p = 0.76). Mortality in longer periods among LLR and RLR amounted to 18.2% vs. 8.0% for 1-year mortality (p = 0.07), 34.1% vs. 26.7% for 2-year mortality (p = 0.13), and 52.3% vs. 48.3% for 3-year mortality (p = 0.46). The length of hospital stay was 5.6 ± 2.5 vs. 5.8 ± 2.1 days, respectively (p = 0.47). There were no significant differences between the incidence of individual complications in the LRL and RLR groups (p = 0.78). Laparoscopic or robotic approaches for colorectal liver metastases are comparable in terms of safety and effectiveness. There are significant advantages to robotic surgery, although there is still no long-term evidence concerning overall survival, and the number of patients operated on using RLR remains small.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Colorectal cancer is the third most common cancer worldwide, and the liver is the most common localization of metastatic disease. The incidence of minimally invasive liver surgery is increasing, and robotic surgery (RLR) is believed to overcome some limitations of a laparoscopic approach (LRL). We performed a systematic review and meta-analysis of operative and short-term oncologic outcomes of the laparoscopic versus robotic-assisted liver resection for colorectal liver metastases. An online search of PubMed, Embase, Scopus, and the Cochrane databases was performed. Eight studies involving 3210 patients were considered eligible for the meta-analysis. In the LRL group, a higher conversion to open rate (12.4%) was observed compared to the RLR (6.7%; p = <0.001). 30-day mortality was 0.7% for the LRL group compared to 0.5% for the RLR group (p = 0.76). Mortality in longer periods among LLR and RLR amounted to 18.2% vs. 8.0% for 1-year mortality (p = 0.07), 34.1% vs. 26.7% for 2-year mortality (p = 0.13), and 52.3% vs. 48.3% for 3-year mortality (p = 0.46). The length of hospital stay was 5.6 ± 2.5 vs. 5.8 ± 2.1 days, respectively (p = 0.47). There were no significant differences between the incidence of individual complications in the LRL and RLR groups (p = 0.78). Laparoscopic or robotic approaches for colorectal liver metastases are comparable in terms of safety and effectiveness. There are significant advantages to robotic surgery, although there is still no long-term evidence concerning overall survival, and the number of patients operated on using RLR remains small.
Hochrainer, Nadine; Serafin, Pawel; D’Ingiullo, Sara; Mollica, Adriano; Granica, Sebastian; Brytan, Marek; Kleczkowska, Patrycja; Spetea, Mariana
In Vitro and In Vivo Pharmacological Profiles of LENART01, a Dermorphin–Ranatensin Hybrid Peptide Journal Article
In: International Journal of Molecular Sciences, vol. 25, no. 7, pp. 4007, 2024, ISSN: 1422-0067.
@article{hochrainer_vitro_2024,
title = {In Vitro and In Vivo Pharmacological Profiles of LENART01, a Dermorphin–Ranatensin Hybrid Peptide},
author = {Nadine Hochrainer and Pawel Serafin and Sara D’Ingiullo and Adriano Mollica and Sebastian Granica and Marek Brytan and Patrycja Kleczkowska and Mariana Spetea},
url = {https://www.mdpi.com/1422-0067/25/7/4007},
doi = {10.3390/ijms25074007},
issn = {1422-0067},
year = {2024},
date = {2024-04-01},
urldate = {2024-10-28},
journal = {International Journal of Molecular Sciences},
volume = {25},
number = {7},
pages = {4007},
abstract = {Diverse chemical and pharmacological strategies are currently being explored to minimize the unwanted side effects of currently used opioid analgesics while achieving effective pain relief. The use of multitarget ligands with activity at more than one receptor represents a promising therapeutic approach. We recently reported a bifunctional peptide-based hybrid LENART01 combining dermorphin and ranatensin pharmacophores, which displays activity to the mu-opioid receptor (MOR) and dopamine D2 receptor (D2R) in rat brains and spinal cords. In this study, we investigated the in vitro binding and functional activities to the human MOR and the in vivo pharmacology of LENART01 in mice after subcutaneous administration. In vitro binding assays showed LENART01 to bind and be selective to the human MOR over the other opioid receptor subtypes and delta, kappa and nociceptin receptors. In the [35S]GTPγS binding assay, LENART01 acted as a potent and full agonist to the human MOR. In mice, LENART01 produced dose-dependent antinociceptive effects in formalin-induced inflammatory pain, with increased potency than morphine. Antinociceptive effects were reversed by naloxone, indicating MOR activation in vivo. Behavioral studies also demonstrated LENART01’s properties to induce less adverse effects without locomotor dysfunction and withdrawal syndrome compared to conventional opioid analgesics, such as morphine. LENART01 is the first peptide-based MOR-D2R ligand known to date and the first dual MOR-dopamine D2R ligand for which in vivo pharmacology is reported with antinociceptive efficacy and reduced opioid-related side effects. Our current findings may pave the way to new pain therapeutics with limited side effects in acute and chronic use.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Diverse chemical and pharmacological strategies are currently being explored to minimize the unwanted side effects of currently used opioid analgesics while achieving effective pain relief. The use of multitarget ligands with activity at more than one receptor represents a promising therapeutic approach. We recently reported a bifunctional peptide-based hybrid LENART01 combining dermorphin and ranatensin pharmacophores, which displays activity to the mu-opioid receptor (MOR) and dopamine D2 receptor (D2R) in rat brains and spinal cords. In this study, we investigated the in vitro binding and functional activities to the human MOR and the in vivo pharmacology of LENART01 in mice after subcutaneous administration. In vitro binding assays showed LENART01 to bind and be selective to the human MOR over the other opioid receptor subtypes and delta, kappa and nociceptin receptors. In the [35S]GTPγS binding assay, LENART01 acted as a potent and full agonist to the human MOR. In mice, LENART01 produced dose-dependent antinociceptive effects in formalin-induced inflammatory pain, with increased potency than morphine. Antinociceptive effects were reversed by naloxone, indicating MOR activation in vivo. Behavioral studies also demonstrated LENART01’s properties to induce less adverse effects without locomotor dysfunction and withdrawal syndrome compared to conventional opioid analgesics, such as morphine. LENART01 is the first peptide-based MOR-D2R ligand known to date and the first dual MOR-dopamine D2R ligand for which in vivo pharmacology is reported with antinociceptive efficacy and reduced opioid-related side effects. Our current findings may pave the way to new pain therapeutics with limited side effects in acute and chronic use.
Sobieraj, Michał; Urbanowicz, Tomasz; Wiśniewska, Anna Olasińska –; Gładki, Marcin; Michalak, Michał; Filipiak, Krzysztof J.; Węclewska, Anita; Bartkowska-Śniatkowska, Alicja; Tykarski, Andrzej; Bobkowski, Waldemar; Jemielity, Marek
Anisocytosis as a possible predictor of low cardiac output syndrome in children undergoing mitral valve surgery Journal Article
In: Advances in Medical Sciences, vol. 69, no. 1, pp. 147–152, 2024, ISSN: 1896-1126, (Publisher: Elsevier BV).
@article{sobieraj_anisocytosis_2024,
title = {Anisocytosis as a possible predictor of low cardiac output syndrome in children undergoing mitral valve surgery},
author = {Michał Sobieraj and Tomasz Urbanowicz and Anna Olasińska – Wiśniewska and Marcin Gładki and Michał Michalak and Krzysztof J. Filipiak and Anita Węclewska and Alicja Bartkowska-Śniatkowska and Andrzej Tykarski and Waldemar Bobkowski and Marek Jemielity},
url = {https://linkinghub.elsevier.com/retrieve/pii/S1896112624000178},
doi = {10.1016/j.advms.2024.03.004},
issn = {1896-1126},
year = {2024},
date = {2024-03-01},
urldate = {2024-09-17},
journal = {Advances in Medical Sciences},
volume = {69},
number = {1},
pages = {147–152},
note = {Publisher: Elsevier BV},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Chirico, Francesco; Szarpak, Lukasz; Pruc, Michal; Rusecka, Joanna; Jannasz, Iwona; Targowski, Tomasz; Bragazzi, Nicola L.; Jankowski, Krzysztof; Rafique, Zubaid; Peacock, Frank William
Systematic review and meta-analysis of the co-occurrence of atrial fibrillation and liver transplantation: a lethal combination Journal Article
In: Disaster and Emergency Medicine Journal, vol. 9, no. 1, pp. 16–22, 2024, ISSN: 2543-5957, 2451-4691, (Publisher: VM Media Group sp. z o.o).
@article{chirico_systematic_2024,
title = {Systematic review and meta-analysis of the co-occurrence of atrial fibrillation and liver transplantation: a lethal combination},
author = {Francesco Chirico and Lukasz Szarpak and Michal Pruc and Joanna Rusecka and Iwona Jannasz and Tomasz Targowski and Nicola L. Bragazzi and Krzysztof Jankowski and Zubaid Rafique and Frank William Peacock},
url = {https://journals.viamedica.pl/disaster_and_emergency_medicine/article/view/96328},
doi = {10.5603/demj.a2023.0029},
issn = {2543-5957, 2451-4691},
year = {2024},
date = {2024-03-01},
urldate = {2024-09-17},
journal = {Disaster and Emergency Medicine Journal},
volume = {9},
number = {1},
pages = {16–22},
note = {Publisher: VM Media Group sp. z o.o},
keywords = {},
pubstate = {published},
tppubtype = {article}
}