Publikacje naukowe

@article{Jeznach2025,

title = {Sepsis-induced inflammasome impairment facilitates development of secondary

            \textit{A. baumannii}

            pneumonia},

author = {Aldona Jeznach and Karolina Sidor-Dzitkowska and Magdalena Bandyszewska and Małgorzata Grzanka and Piotr Popławski and Anna Marszalik and Joanna Domagała-Kulawik and Radosław Stachowiak and Grażyna Hoser and Tomasz Skirecki},

doi = {10.1080/22221751.2025.2492206},

issn = {2222-1751},

year  = {2025},

date = {2025-12-31},

journal = {Emerging Microbes & Infections},

volume = {14},

number = {1},

publisher = {Informa UK Limited},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Filipiak2025,

title = {EASY OR NOT. European-Asian Six countries Yearly consensus On Recent guidelines: arterial hypertension, atrial fibrillation, chronic coronary syndromes, and peripheral artery diseases. Novel Or conventional Treatment options for these patients. Position Paper 2024},

author = {Krzysztof J. Filipiak and Matteo Cameli and Santiago J. Freire and Rahima Gabulova and Gulnoz Khamidullaeva and Anna Tomaszuk-Kazberuk and Agnieszka Kuzior and Francisco Javier Martinez-Martin and Ulvi Mirzayev and Ulugbek Nizamov and Nguyen Van Tan and Aleksandra Gąsecka},

doi = {10.5603/cj.105140},

issn = {1898-018X},

year  = {2025},

date = {2025-05-13},

journal = {Cardiol J.},

publisher = {VM Media Group sp. z o.o},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Trojnar2025,

title = {Current insights into the clinico-pathologic characteristics of lung cancer in women},

author = {Anna Trojnar and Joanna Domagała-Kulawik},

doi = {10.1080/17476348.2025.2475974},

issn = {1747-6356},

year  = {2025},

date = {2025-04-03},

journal = {Expert Review of Respiratory Medicine},

volume = {19},

number = {4},

pages = {301--312},

publisher = {Informa UK Limited},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Świeca2025,

title = {Maternal Uniparental Isodisomy of Chromosome 6: A Novel Case of Teratoma and Autism Spectrum Disorder with a Diagnostic and Management Framework},

author = {Aleksandra Świeca and Maria Franaszczyk and Agnieszka Maryniak and Patryk Lipiński and Rafał Płoski and Krzysztof Szczałuba},

doi = {10.3390/genes16040434},

issn = {2073-4425},

year  = {2025},

date = {2025-04-00},

journal = {Genes},

volume = {16},

number = {4},

publisher = {MDPI AG},

abstract = {Background: Uniparental disomy (UPD) is the inheritance of both copies of a chromosome from a single parent, leading to distinct genetic conditions. Maternal UPD of chromosome 6 (UPD(6)mat) is extremely rare, with few molecularly confirmed cases reported. Methods: We report a prematurely born female with isodisomic UPD(6)mat, presenting with intrauterine growth restriction (IUGR), developmental delay, autism spectrum disorder, dysmorphic features, and a sacrococcygeal teratoma. In addition, we reviewed 24 confirmed UPD(6)mat cases to assess clinical patterns in prenatal findings, birth outcomes, and postnatal features. Results: Trio whole-exome sequencing revealed complete isodisomy of chromosome 6 and a de novo heterozygous DIAPH2 variant of uncertain significance. In the literature review, IUGR was present in 87% of cases, with most individuals born small for gestational age and preterm. Failure to thrive and neurodevelopmental issues were also frequent. While the exact molecular basis remains unknown, imprinting disturbances—similar to those in UPD(6)pat—and cryptic trisomy 6 mosaicism, particularly in heterodisomy, are the most likely mechanisms. No specific gene or consistent epigenetic abnormality has been identified. Conclusions: This study aims to enhance the understanding of the genetic and phenotypic spectrum of UPD(6)mat, improving diagnostic and management approaches for this ultra-rare genetic disorder. We propose a detailed list of clinical assessments and tests to be performed following the detection of maternal uniparental disomy of chromosome 6.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Wełnicki2025,

title = {Treatment of dyslipidemia in Poland — common diagnostics, early combined therapy. Expert position statement endorsed by the Polish Cardiac Society Working Group on Cardiovascular Pharmacotherapy. 5th Declaration of Sopot},

author = {Marcin Wełnicki and Iwona Gorczyca-Głowacka and Agnieszka Kapłon-Cieślicka and Maciej Janiszewski and Jarosław D. Kasprzak and Przemysław Leszek and Anna Tomaszuk-Kazberuk and Maria Łukasiewicz and Mariusz Tomaniak and Stanisław Surma and Agnieszka Mickiewicz and Krzysztof Narkiewicz and Miłosz Jaguszewski and Zbigniew Krasiński and Daniel Śliż and Artur Mamcarz and Filip M. Szymański and Marcin Barylski and Beata Wożakowska-Kapłon and Krzysztof J. Filipiak},

doi = {10.5603/cj.103680},

issn = {1898-018X},

year  = {2025},

date = {2025-03-31},

journal = {Cardiol J.},

volume = {32},

number = {2},

pages = {107--119},

publisher = {VM Media Group sp. z o.o},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Safiejko2025,

title = {Resistin as potential biomarkers for detection of colorectal carcinoma: A systematic review and meta-analysis},

author = {Kamil Safiejko and Marcin Juchimiuk and Jacek Pierko and Slawomir Lewicki and Michal Pruc and Sebastian Radej and Pawel Czubak and Aleksander Tarasik and Maciej Olszewski and Lukasz Szarpak},

doi = {10.5603/mrj.103985},

issn = {2451-4101},

year  = {2025},

date = {2025-03-11},

journal = {Med Res J},

volume = {10},

number = {1},

pages = {23--30},

publisher = {VM Media Group sp. z o.o},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Gąsecka2025,

title = {Transcatheter aortic valve implantation reduces plasma concentrations of TMAO and indoxyl sulfate: A prospective, multicenter cohort study},

author = {Aleksandra Gąsecka and Marcelina Gniot and Bogna Rajewska and Weronika Dykacz and Weronika Kisielewska and Ewelina Błażejowska and Jakub M. Zimodro and Marcin Grabowski and Bartosz Rymuza and Zenon Huczek and Janusz Kochman and Radosław Wilimski and Mariusz Kuśmierczyk and Jan Budzianowski and Jarosław Hiczkiewicz and Anna Olasińska-Wiśniewska and Marek Grygier and Krzysztof J. Filipiak and Marcin Ufnal},

doi = {10.5603/cj.102844},

issn = {1898-018X},

year  = {2025},

date = {2025-03-10},

journal = {Cardiol J.},

volume = {32},

number = {2},

pages = {164--174},

publisher = {VM Media Group sp. z o.o},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{trojnar_current_2025,

title = {Current insights into the clinico-pathologic characteristics of lung cancer in women},

author = {Anna Trojnar and Joanna Domagała-Kulawik},

url = {https://www.tandfonline.com/doi/full/10.1080/17476348.2025.2475974},

doi = {10.1080/17476348.2025.2475974},

issn = {1747-6348, 1747-6356},

year  = {2025},

date = {2025-03-01},

urldate = {2025-03-14},

journal = {Expert Review of Respiratory Medicine},

pages = {1–12},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Uliński2025,

title = {Early-Onset COPD and Lung Cancer: Case Studies Highlighting Diagnostic Challenges in Younger Patients},

author = {Robert Uliński and Piotr Korczyński and Joanna Domagała-Kulawik},

doi = {10.12659/ajcr.946280},

issn = {1941-5923},

year  = {2025},

date = {2025-02-12},

journal = {Am J Case Rep},

volume = {26},

publisher = {International Scientific Information, Inc.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Lipiński2025b,

title = {Case Report: Cholestatic liver disease in the course of erythropoietic protoporphyria associated with renal hypodysplasia and atrial septal defect},

author = {Patryk Lipiński and Agnieszka Lipniacka and Maja Klaudel-Dreszler and Lidia Ziółkowska and Grażyna Kostrzewa and Edyta Odnoczko and Robert Wasilewski and Rafał Płoski and Anna Tylki-Szymańska},

doi = {10.3389/fped.2025.1504181},

issn = {2296-2360},

year  = {2025},

date = {2025-02-11},

journal = {Front. Pediatr.},

volume = {13},

publisher = {Frontiers Media SA},

abstract = {Erythropoietic protoporphyria (EPP) is an autosomal recessive disorder of the heme biosynthesis pathway caused by pathogenic variants in FECH gene resulting in a decreased activity of ferrochelatase. Liver involvement is observed in 5%–20% of patients harbouring loss-of-function FECH variants and its manifestations are heterogeneous, ranging from mildly elevated liver transaminases, cholelithiasis to severe acute cholestatic hepatitis/liver failure. This paper presents the case of a Polish infant with EPP associated with two novel missense FECH variants accompanied by other congenital anomalies, namely atrial septal defect and renal hypodysplasia. Progressive cholestatic liver disease (with subsequent congestive heart failure) was observed in the course of EPP. Erytropoietic protoporphyria should be considered in patients with hepatosplenomegaly and cholestasis accompanied by skin damage. The natural history of liver disease in the course of EPP could be determined by other factors, like the co-existence of congenital anomalies.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{maj_key_2025,

title = {Key considerations regarding veno-arterial extracorporeal membrane oxygenation for the treatment of cardiogenic shock and cardiac arrest − Letter to Son et al.},

author = {Bartosz Maj and Michal Pruc and Lukasz Szarpak},

url = {https://linkinghub.elsevier.com/retrieve/pii/S0964339724001903},

doi = {10.1016/j.iccn.2024.103805},

issn = {09643397},

year  = {2025},

date = {2025-02-01},

urldate = {2024-10-28},

journal = {Intensive and Critical Care Nursing},

volume = {86},

pages = {103805},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Lewicki2025,

title = {Immunological Insights and Therapeutic Advances in COPD: Exploring Oral Bacterial Vaccines for Immune Modulation and Clinical Improvement},

author = {Sławomir Lewicki and Barbara Joanna Bałan and Marta Stelmasiak and Dorota Magdalena Radomska-Leśniewska and Łukasz Szymański and Natalia Rios-Turek and Justyna Bień-Kalinowska and Łukasz Szarpak and Bogdan Hajduk},

doi = {10.3390/vaccines13020107},

issn = {2076-393X},

year  = {2025},

date = {2025-02-00},

journal = {Vaccines},

volume = {13},

number = {2},

publisher = {MDPI AG},

abstract = {Chronic obstructive pulmonary disease (COPD) is a prevalent chronic condition associated with substantial global morbidity and mortality. Primarily caused by prolonged exposure to harmful agents such as dust and gases, COPD is characterized by persistent airflow limitation, clinically manifesting as chronic cough, sputum production, and dyspnea. The disease course alternates between stable phases and exacerbations, with the latter often associated with pathogenic colonization of the respiratory tract. This review examines the immunological underpinnings of COPD, emphasizing the interplay between innate and adaptive immunity in disease pathogenesis. Dysregulated immune responses to environmental factors perpetuate chronic inflammation, resulting in progressive pulmonary epithelial damage and connective tissue hyperplasia, which compromise gas exchange. Exacerbations further exacerbate respiratory failure, aggravating patient symptoms and accelerating disease progression. Despite advances in COPD management, effective therapeutic options remain limited. Current treatments primarily aim to alleviate symptoms, reduce immune activation, and manage infections, yet many patients experience suboptimal outcomes. This review highlights the potential of novel therapeutic approaches targeting immune system cells and pathways. In particular, it explores the promise of oral bacterial vaccines as immunomodulatory agents to enhance immune responses and improve clinical outcomes in COPD, addressing critical gaps in current treatment paradigms.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{grygiel_reciprocal_nodate,

title = {The reciprocal relationship between depressive symptoms and loneliness among people diagnosed with psychotic disorders: a cross-lagged panel analysis},

author = {Paweł Grygiel and Janina Sonik-Włodarczyk and Marta Anczewska and Piotr Świtaj},

year  = {2025},

date = {2025-01-14},

journal = {Archives of Psychiatry and Psychotherapy},

abstract = {Aim of the study: To investigate prospective relationships between depressive symptoms and loneliness among people with psychotic disorders.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{skrzypecki_night-time_2025,

title = {Night-time blood pressure dipping, but not 24-h blood pressure level, is linked to increased 24-h ocular volume slope},

author = {Janusz Skrzypecki and Fm Szymański and J. Przybek-Skrzypecka and Justyna Izdebska and A. Ryś-Czaporowska and Kj Filipiak and Jacek P. Szaflik},

url = {https://www.scielo.br/j/abo/a/xthz4cH8bzvhnRRSjmTGkLM/?lang=en},

doi = {10.5935/0004-2749.2022-0236},

issn = {00042749},

year  = {2025},

date = {2025-01-01},

urldate = {2024-10-28},

journal = {Arquivos Brasileiros de Oftalmologia},

volume = {88},

number = {1},

pages = {01–07},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{lewicki_immunological_2025,

title = {Immunological Insights and Therapeutic Advances in COPD: Exploring Oral Bacterial Vaccines for Immune Modulation and Clinical Improvement},

author = {Sławomir Lewicki and Barbara Joanna Bałan and Marta Stelmasiak and Dorota Magdalena Radomska-Leśniewska and Łukasz Szymański and Natalia Rios-Turek and Justyna Bień-Kalinowska and Łukasz Szarpak and Bogdan Hajduk},

url = {https://www.mdpi.com/2076-393X/13/2/107},

doi = {10.3390/vaccines13020107},

issn = {2076-393X},

year  = {2025},

date = {2025-01-01},

urldate = {2025-03-14},

journal = {Vaccines},

volume = {13},

number = {2},

pages = {107},

abstract = {Chronic obstructive pulmonary disease (COPD) is a prevalent chronic condition associated with substantial global morbidity and mortality. Primarily caused by prolonged exposure to harmful agents such as dust and gases, COPD is characterized by persistent airflow limitation, clinically manifesting as chronic cough, sputum production, and dyspnea. The disease course alternates between stable phases and exacerbations, with the latter often associated with pathogenic colonization of the respiratory tract. This review examines the immunological underpinnings of COPD, emphasizing the interplay between innate and adaptive immunity in disease pathogenesis. Dysregulated immune responses to environmental factors perpetuate chronic inflammation, resulting in progressive pulmonary epithelial damage and connective tissue hyperplasia, which compromise gas exchange. Exacerbations further exacerbate respiratory failure, aggravating patient symptoms and accelerating disease progression. Despite advances in COPD management, effective therapeutic options remain limited. Current treatments primarily aim to alleviate symptoms, reduce immune activation, and manage infections, yet many patients experience suboptimal outcomes. This review highlights the potential of novel therapeutic approaches targeting immune system cells and pathways. In particular, it explores the promise of oral bacterial vaccines as immunomodulatory agents to enhance immune responses and improve clinical outcomes in COPD, addressing critical gaps in current treatment paradigms.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{switaj_examining_2025,

title = {Examining the relationships between self-stigma, loneliness, depressive symptoms, and suicidal ideation among people with bipolar disorder},

author = {Piotr Świtaj and Paweł Grygiel and Joanna Leciak and Izabela Stefaniak and Sylwia Opozda-Suder and Marta Anczewska},

url = {https://www.nature.com/articles/s41598-025-87559-7},

doi = {10.1038/s41598-025-87559-7},

issn = {2045-2322},

year  = {2025},

date = {2025-01-01},

urldate = {2025-03-14},

journal = {Scientific Reports},

volume = {15},

number = {1},

pages = {3432},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{jozwiak_multifunctionality_2025,

title = {Multifunctionality and Possible Medical Application of the BPC 157 Peptide—Literature and Patent Review},

author = {Michalina Józwiak and Marta Bauer and Wojciech Kamysz and Patrycja Kleczkowska},

url = {https://www.mdpi.com/1424-8247/18/2/185},

doi = {10.3390/ph18020185},

issn = {1424-8247},

year  = {2025},

date = {2025-01-01},

urldate = {2025-03-14},

journal = {Pharmaceuticals},

volume = {18},

number = {2},

pages = {185},

abstract = {BPC 157, known as the “Body Protection Compound”, is a pentadecapeptide isolated from human gastric juice that demonstrated its pleiotropic beneficial effects in various preclinical models mimicking medical conditions, such as tissue injury, inflammatory bowel disease, or even CNS disorders. Unlike many other drugs, BPC 157 has a desirable safety profile, since only a few side effects have been reported following its administration. Nevertheless, this compound was temporarily banned by the World Anti-Doping Agency (WADA) in 2022 (it is not currently listed as banned by the WADA). However, it has not been approved for use in standard medicine by the FDA and other global regulatory authorities due to the absence of sufficient and comprehensive clinical studies confirming its health benefits in humans. In this review, we summarize information on the biological activities of BPC 157, with particular reference to its mechanism of action and probable toxicity. This generated the attention of experts, as BPC 157 has been offered for sale on many websites. We also present recent interest in BPC 157 as reflected in a number of patent applications and granted patents.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid40178258,

title = {Guidelines for the management of hypertension in Poland 2024 - the position paper of the Polish Society of Hypertension and Polish Cardiac Society experts},

author = {Aleksander Prejbisz and Piotr Dobrowolski and Adrian Doroszko and Agnieszka Olszanecka and Agnieszka Tycińska and Andrzej Tykarski and Marcin Adamczak and Beata Begier-Krasińska and Marzena Chrostowska and Grzegorz Dzida and Krzysztof J Filipiak and Zbigniew Gaciong and Dariusz Gąsecki and Marek Gierlotka and Marcin Grabowski and Tomasz Grodzicki and Piotr Jankowski and Karol Kamiński and Agnieszka Kapłon-Cieślicka and Aneta Klotzka and Dariusz Kozłowski and Przemysław Leszek and Jacek Lewandowski and Mieczysław Litwin and Łukasz Obrycki and Artur Mamcarz and Przemysław Mitkowski and Beata Naumnik and Marek Rajzer and Janina Stępińska and Katarzyna Stolarz-Skrzypek and Anna Szyndler and Anna Tomaszuk-Kazberuk and Izabella Uchmanowicz and Marcin Wełnicki and Barbara Wizner and Beata Wożakowska-Kapłon and Tomasz Zdrojewski and Waldemar Banasiak and Andrzej Januszewicz and Agnieszka Mastalerz-Migas and Krzysztof Narkiewicz and Andrzej Więcek and Adam Witkowski and Robert Gil and Jacek Wolf},

doi = {10.33963/v.phj.105628},

issn = {1897-4279},

year  = {2025},

date = {2025-01-01},

journal = {Kardiol Pol},

volume = {83},

number = {3},

pages = {370--411},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Lipiński2025,

title = {Autism spectrum disorder and inherited metabolic diseases: are there any 

common features?},

author = {Patryk Lipiński},

doi = {10.5114/pedm.2025.148397},

issn = {2081-237X},

year  = {2025},

date = {2025-00-00},

journal = {pedm},

volume = {31},

number = {1},

pages = {30--34},

publisher = {Termedia Sp. z.o.o.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{bauer_marine_2024,

title = {Marine Peptides: Potential Basic Structures for the Development of Hybrid Compounds as Multitarget Therapeutics for the Treatment of Multifactorial Diseases},

author = {Marta Bauer and Magdalena Glowacka and Wojciech Kamysz and Patrycja Kleczkowska},

url = {https://www.mdpi.com/1422-0067/25/23/12601},

doi = {10.3390/ijms252312601},

issn = {1422-0067},

year  = {2024},

date = {2024-11-01},

urldate = {2025-03-14},

journal = {International Journal of Molecular Sciences},

volume = {25},

number = {23},

pages = {12601},

abstract = {Marine-derived peptides display potent antihypertensive, antioxidant, analgesic and antimicrobial biological effects. Some of them have also been found to have anticancer activity via various mechanisms differing from those of continental organisms. This diversity of properties—together with the peptides’ efficacy, which has been confirmed in several in vitro and in vivo studies—make these compounds attractive as functional ingredients in pharmacy, especially in regard to multitarget drugs known as hybrids. Given the possibilities offered by chimeric structures, it is expected that a hybridization strategy based on a marine-derived compound could result in a long-awaited success in the development of new effective compounds to combat a range of complex diseases. However, despite the fact that the biological activity of such new hybrids may exceed that of their parent compounds, there is still an urgent need to carefully determine their potential off-targets and thus possible clinically important side effects. Given the above, the aim of this paper is to provide information on compounds of marine origin with peptide structures and to verify the occurrence and usage of hybrid compounds built from these structures. Furthermore, the authors believe that information presented here will serve to increase public awareness of the new opportunities arising from the combination of hybridization strategies with marine molecules with known structures and biological properties, thereby accelerating the development of effective drug candidates.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{lipinski_chronic_2024,

title = {Chronic acid sphingomyelinase deficiency diagnosed in infancy/childhood in Polish patients: 2024 update},

author = {Patryk Lipiński and Agnieszka Ługowska and Anna Tylki-Szymańska},

url = {https://advances.umw.edu.pl/en/article/2024/33/10/1163/},

doi = {10.17219/acem/193696},

issn = {1899-5276},

year  = {2024},

date = {2024-10-01},

urldate = {2024-10-28},

journal = {Advances in Clinical and Experimental Medicine},

volume = {33},

number = {10},

pages = {1163–1168},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{klingemann_peer_2024,

title = {Peer Support Workers in Mental Health Services: A Qualitative Exploration of Emotional Burden, Moral Distress and Strategies to Reduce the Risk of Mental Health Crisis},

author = {Justyna Klingemann and Halina Sienkiewicz-Jarosz and Bartłomiej Molenda and Piotr Świtaj},

url = {https://link.springer.com/10.1007/s10597-024-01370-8},

doi = {10.1007/s10597-024-01370-8},

issn = {0010-3853, 1573-2789},

year  = {2024},

date = {2024-10-01},

urldate = {2024-10-28},

journal = {Community Mental Health Journal},

abstract = {Abstract 

 This research aimed to explore the experience of emotional burden among peer support workers (PSWs) in mental health care in Poland. It also examined the issue of moral distress in relation to this professional group and identified institutional sources of support for the well-being of PSWs in the workplace. The data presented in the article are derived from fourteen qualitative in-depth individual interviews with PSWs employed in four mental health centres with different organisational structures. The narratives of PSWs revealed several experiences that could be considered to be moral distress. The inability to assist patients was found to be associated with both individual and institutional barriers. Furthermore, our findings suggest that organisations can implement a number of specific practices to ensure the wellbeing of PSWs, which dissemination would be beneficial to teams employing PSWs.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{fraczek-cendrowska_evaluation_2024,

title = {Evaluation of the Effectiveness of a Group CBT-Based Intervention Aiming to Reduce Self-Stigma and Improve Recovery-Related Outcomes in People with Severe Mental Disorders: Randomised Controlled Trial},

author = {Katarzyna Frączek-Cendrowska and Piotr Świtaj and Izabela Stefaniak},

url = {https://link.springer.com/10.1007/s11126-024-10092-9},

doi = {10.1007/s11126-024-10092-9},

issn = {0033-2720, 1573-6709},

year  = {2024},

date = {2024-10-01},

urldate = {2024-10-28},

journal = {Psychiatric Quarterly},

abstract = {Abstract 

 Self-stigma is a major barrier to personal and clinical recovery in people with mental illness. Although psychosocial interventions have been developed to reduce self-stigma, the exploration of group CBT-based interventions for hospitalised patients are less represented. The purpose of this trial is to investigate the effectiveness of a group CBT-based intervention aiming to reduce self-stigma and improve recovery-related outcomes such as self-esteem, stigma resistance and sense of coherence, which comes down to saying, “I am what I am”. A total of 104 patients admitted to the inpatient therapy were recruited to participate in a randomised controlled clinical trial, and 77 participants (46 in the intervention group and 31 in the control group) completed the trial. Constructs of interest were measured before and after the intervention. The results showed that the evaluated intervention was effective in improving sense of coherence and stigma resistance, compared to treatment as usual (TAU). The level of self-stigma significantly decreased in both the intervention and control groups, but no statistically significant difference was observed between the groups. The limitations of the study include: the lack of assessment of the sustainability of the effects of therapy (follow-up), the presence of intensive interventions of the ward’s programme and patients pre-qualified for the ward based on admission criteria. The intervention “I am what I am,” has proven to be effective, especially in increasing the level of personal resources needed to build clinical and personal recovery and to counteract the negative consequences of self-stigma.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pruc_prognostic_2024,

title = {Prognostic value of the monocyte-to-high-density lipoprotein-cholesterol ratio in ACS patients: A systematic review and meta-analysis},

author = {Michał Pruc and Jacek Kubica and Maciej Banach and Damian Świeczkowski and Zubaid Rafique and William Frank Peacock and Zbigniew Siudak and Stanisław Surma and Prabath Nanayakkara and Krzysztof Kurek and Anne Lepetit and Łukasz Szarpak},

url = {https://journals.viamedica.pl/polish_heart_journal/article/view/102773},

doi = {10.33963/v.phj.102773},

issn = {1897-4279, 0022-9032},

year  = {2024},

date = {2024-10-01},

urldate = {2024-10-28},

journal = {Polish Heart Journal},

pages = {VM/OJS/J/102773},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{kurek_gray-white_2024,

title = {The gray-white matter ratio in adult out-of-hospital cardiac arrest patients must be assessed comprehensively},

author = {Krzysztof Kurek and Michal Pruc and Lukasz Szarpak},

url = {https://linkinghub.elsevier.com/retrieve/pii/S0300957224002594},

doi = {10.1016/j.resuscitation.2024.110365},

issn = {03009572},

year  = {2024},

date = {2024-10-01},

urldate = {2024-10-28},

journal = {Resuscitation},

volume = {203},

pages = {110365},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{khamisy-farah_gender_2024,

title = {Gender and Sexuality Awareness in Medical Education and Practice: Mixed Methods Study},

author = {Rola Khamisy-Farah and Eden Biras and Rabie Shehadeh and Ruba Tuma and Hisham Atwan and Anna Siri and Manlio Converti and Francesco Chirico and Łukasz Szarpak and Carlo Biz and Raymond Farah and Nicola Bragazzi},

url = {https://mededu.jmir.org/2024/1/e59009},

doi = {10.2196/59009},

issn = {2369-3762},

year  = {2024},

date = {2024-10-01},

urldate = {2024-10-28},

journal = {JMIR Medical Education},

volume = {10},

pages = {e59009},

abstract = {Background 

 The integration of gender and sexuality awareness in health care is increasingly recognized as vital for patient outcomes. Despite this, there is a notable lack of comprehensive data on the current state of physicians’ training and perceptions in these areas, leading to a gap in targeted educational interventions and optimal health care delivery. 

 Objective 

 The study’s aim was to explore the experiences and perceptions of attending and resident physicians regarding the inclusion of gender and sexuality content in medical school curricula and professional practice in Israel. 

 Methods 

 This cross-sectional survey targeted a diverse group of physicians across various specializations and experience levels. Distributed through Israeli Medical Associations and professional networks, it included sections on experiences with gender and sexuality content, perceptions of knowledge, the impact of medical school curricula on professional capabilities, and views on integrating gender medicine in medical education. Descriptive and correlational analyses, along with gender-based and medical status-based comparisons, were used, complemented, and enhanced by qualitative analysis of participants’ replies. 

 Results 

 The survey, encompassing 189 respondents, revealed low-to-moderate exposure to gender and sexuality content in medical school curricula, with a similar perception of preparedness. A need for more comprehensive training was widely recognized. The majority valued training in these areas for enhancing professional capabilities, identifying 10 essential gender-related knowledge areas. The preference for integrating gender medicine throughout medical education was significant. Gender-based analysis indicated variations in exposure and perceptions. 

 Conclusions 

 The study highlights a crucial need for the inclusion of gender and sexuality awareness in medical education and practice. It suggests the necessity for curriculum development, targeted training programs, policy advocacy, mentorship initiatives, and research to evaluate the effectiveness of these interventions. The findings serve as a foundation for future directions in medical education, aiming for a more inclusive, aware, and prepared medical workforce.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{urbanowicz_possible_2024,

title = {The Possible Role of PM2.5 Chronic Exposure on 5-Year Survival in Patients with Left Ventricular Dysfunction Following Coronary Artery Bypass Grafting},

author = {Tomasz Urbanowicz and Krzysztof Skotak and Anna Olasińska-Wiśniewska and Krzysztof J Filipiak and Aleksandra Płachta-Krasińska and Jakub Piecek and Beata Krasińska and Zbigniew Krasiński and Andrzej Tykarski and Marek Jemielity},

url = {https://www.mdpi.com/2305-6304/12/10/697},

doi = {10.3390/toxics12100697},

issn = {2305-6304},

year  = {2024},

date = {2024-09-01},

urldate = {2024-10-28},

journal = {Toxics},

volume = {12},

number = {10},

pages = {697},

abstract = {Background: The survival benefit of surgical revascularization in multivessel coronary artery disease is well understood, though it can be modified by left ventricular dysfunction. Chronic exposure to air pollutants has gained more attention recently as a possible non-traditional morbidity and mortality cardiovascular risk factor. This study identified possible 5-year mortality risk factors related to postoperative left ventricular performance, including air pollutants. Patients: There were 283 patients (244 (86%) males) with a median age of 65 (60–70) years enrolled in the retrospective analysis. All patients were referred for off-pump coronary artery revascularization due to chronic coronary syndrome that presented as a multivessel coronary artery disease. They were divided into three groups depending on the postoperative course of left ventricular fraction (LVEF 50% or more (169 patients), LVEF between 41 and 49% (61 patients), and LVEF 40% or less (53 patients)). Results: The overall survival rate was 84% (237 patients) in a median follow-up time of 5.3 (4.8–6.1) years. The median (Q1–Q3) chronic air pollution exposures for the analyzed group were 19.3 (16.9–22.4) μg/m3 for fine particles such as PM2.5, 25.8 (22.5–29.4) μg/m3 for coarse particles such as PM10, and 12.2 (9.7–14.9) μg/m3 for nitric dioxide (NO2). The mortality in the first group (LVEF at least 50%) was 23 (13.6%), in the second group (LVEF 41–49%) was 9 (15%), and in the third group (LVEF 40% or less) was 14 (26%). The multivariable regression analysis for the five-year mortality risk in the first group revealed the predictive value of dyslipidemia (HR: 3.254, 95% CI: 1.008–10.511},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{urbanowicz_neutrophil_2024,

title = {Neutrophil Extracellular Trap Formation in Advanced Heart Failure Patients—Preliminary Report},

author = {Tomasz Urbanowicz and Anna Olasińska-Wiśniewska and Ewelina Wojtasińska and Krzysztof J. Filipiak and Małgorzata Tomaszewska and Jędrzej Sikora and Marta Krama and Zofia Radek and Kajetan Grodecki and Aleksandra Krasińska-Płachta and Beata Krasińska and Zbigniew Krasiński and Andrzej Tykarski and Marek Jemielity and Joanna Rupa-Matysek},

url = {https://www.mdpi.com/1422-0067/25/17/9633},

doi = {10.3390/ijms25179633},

issn = {1422-0067},

year  = {2024},

date = {2024-09-01},

urldate = {2024-10-28},

journal = {International Journal of Molecular Sciences},

volume = {25},

number = {17},

pages = {9633},

abstract = {In end-stage heart failure, which is characterized by persistent or progressive ventricular dysfunction despite optimal medical therapy, a left ventricular assist device (LVAD) can be beneficial. Congestive heart failure provokes inflammatory and prothrombotic activation. The aim of this study was to evaluate the serum concentration of citrullinated histone 3 (CH3) representing neutrophil extracellular trap (NET) formation in patients referred for LVAD implantation. There were 10 patients with a median age of 61 (57–65) years enrolled in a prospective single-center analysis who underwent LVAD implantation. The CH3 plasma concentration was measured preoperatively and on the 1st and 7th postoperative days, followed by control measurements on the median (Q1–3) 88th (49–143) day. The preoperative CH3 concentration strongly correlated with brain natriuretic peptide (r = 0.879, p < 0.001). Significant differences in CH3 serum concentration were observed between pre- and postoperative measurements, including an increase on the first postoperative day (p < 0.001), as well as a decrease on the seventh day (p = 0.016) and in follow-up (p < 0.001). CH3 concentration, as a marker of NET formation, decreases after LVAD implantation.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{lipinski_case_2024,

title = {Case report: Early (molecular) diagnosis is the clue: report on ALDH7A1 deficiency in newborns},

author = {Patryk Lipiński and Katarzyna Wójcicka-Kowalczyk and Anna Bogdańska and Ewa Ehmke and Magdalena Pajdowska and Katarzyna Skrzypek and Agnieszka Charzewska and Dorota Hoffman-Zacharska},

url = {https://www.frontiersin.org/articles/10.3389/fgene.2024.1464556/full},

doi = {10.3389/fgene.2024.1464556},

issn = {1664-8021},

year  = {2024},

date = {2024-09-01},

urldate = {2024-10-28},

journal = {Frontiers in Genetics},

volume = {15},

pages = {1464556},

abstract = {The first-tier genetic testing for developmental and epileptic encephalopathies (DEE) is now increasingly used in routine clinical practice. Antiquitin deficiency, also referred to as pyridoxine-dependent epilepsy (PDE-ALDH7A1), represents an inherited metabolic disorder with the phenotype of an early infantile DEE. In addition to the fact that biochemical biomarkers of PDE-ALDH7A1, including α-aminoadipic semialdehyde dehydrogenase, pipecolic acid (PA), Δ1-piperideine-6-carboxylate, and 6-oxopipecolate (6-oxo-PIP), are well-characterized, and their analysis and usefulness have some limitations. Here, we describe the case of a newborn presenting with seizures from the first hours of life, who was resistant to standard antiepileptic drugs and was found to be a biallelic compound heterozygote of two clearly pathogenic variants in the 

 ALDH7A1 

 gene based on targeted next-generation sequencing (NGS). The diagnostic process of PDE-ALDH7A1 was limited by the possibility to determine only urinary PA and 6-oxo-PIP (urinary organic acid profile using the GC–MS method), and the exogenous peak of levetiracetam, due to the fact that it has a similar retention time as 6-oxo-PIP, masked the detection of 6-oxo-PIP.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{gasecka_leukocyte_2024,

title = {Leukocyte Extracellular Vesicles Predict Progression of Systolic Dysfunction in Heart Failure with Mildly Reduced Ejection Fraction (LYCHEE) – A Prospective, Multicentre Cohort Study},

author = {Aleksandra Gąsecka and Aleksander Siniarski and Piotr Duchnowski and Konrad Stępień and Ewelina Błażejowska and Magdalena Gajewska and Kacper Karaban and Kinga Porębska and Aleksandra Reda and Sylwester Rogula and Bartosz Rolek and Dorota Słupik and Roksana Gozdowska and Marcin Kleibert and Dominika Zajkowska and Michał Grąt and Marcin Grabowski and Krzysztof J. Filipiak and Edwin Van Der Pol and Rienk Nieuwland},

url = {https://link.springer.com/10.1007/s12265-024-10561-3},

doi = {10.1007/s12265-024-10561-3},

issn = {1937-5387, 1937-5395},

year  = {2024},

date = {2024-09-01},

urldate = {2024-10-28},

journal = {Journal of Cardiovascular Translational Research},

abstract = {Abstract 

 Risk stratification in heart failure with mildly-reduced ejection fraction (HFmrEF) remains challenging. We evaluated the predictive value of advanced glycation end products (AGEs) and plasma concentrations of extracellular vesicles (EVs) for the systolic and diastolic dysfunction progression in HFmrEF patients. Skin AGE accumulation was measured using AGE Reader. Plasma EV concentrations were measured using flow cytometry. Among 74 patients enrolled, 13 (18%) had systolic dysfunction progression and 5 (7%) had diastolic dysfunction progression during 6.5 months follow-up. Leukocyte EVs concentrations were higher in patients with systolic dysfunction progression ( 

 p = 0.002) and predicted the progression with 75.0% sensitivity and 58.3% specificity, independent of other clinical variables (OR 4.72, 95% CI 0.99–22.31). Skin AGE levels and concentrations of other EV subtypes were not associated with systolic or diastolic dysfunction progression. Increased leukocyte EVs concentrations are associated with 4.7-fold higher odds of systolic dysfunction progression in HFmrEF patients. 

 Graphical Abstract 

 AGE – advanced glycation end products, HFmrEF – heart failure with mildly reduced ejection fraction, ECHO – echocardiography, EV – extracellular vesicles},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{urbanowicz_what_2024,

title = {What Can We Learn from the Scalp Hair’s Trace Element Content? The Relationship with the Advancement of Coronary Artery Disease},

author = {Tomasz Urbanowicz and Anetta Hanć and Julia Frąckowiak and Maksymilian Białasik-Misiorny and Zofia Radek and Marta Krama and Krzysztof J. Filipiak and Aleksandra Krasińska-Płachta and Sylwia Iwańczyk and Mariusz Kowalewski and Andrzej Tykarski and Marek Jemielity},

url = {https://www.mdpi.com/2077-0383/13/17/5260},

doi = {10.3390/jcm13175260},

issn = {2077-0383},

year  = {2024},

date = {2024-09-01},

urldate = {2024-10-28},

journal = {Journal of Clinical Medicine},

volume = {13},

number = {17},

pages = {5260},

abstract = {Background: Multiple risk factors for coronary artery disease have been identified without answering one of the leading questions related to the extent of the involvement of the epicardial arteries. Trace elements are involved in various stages of atherosclerotic lesion formation and may play a significant role in the advancement of coronary artery disease. Methods: A total of 157 (92 (59%) men and 65 (41%) women) patients with a median age of 71 (65–75) years presenting with chronic coronary syndrome were enrolled in the prospective single-center analysis. The coronary angiography results were compared with the concentration of trace elements in scalp hair. Results: Through Spearman analysis, a positive correlation between the number of diseased coronary arteries and hair trace element concentration was found for sodium (r = 0.198},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{lipinski_body_2024,

title = {Body Height of MPS I and II Patients after Hematopoietic Stem Cell Transplantation: The Impact of Dermatan Sulphate},

author = {Patryk Lipiński and Agnieszka Różdżyńska-Świątkowska and Agnieszka Ługowska and Jolanta Marucha and Katarzyna Drabko and Anna Tylki-Szymańska},

url = {https://www.mdpi.com/2075-4418/14/17/1956},

doi = {10.3390/diagnostics14171956},

issn = {2075-4418},

year  = {2024},

date = {2024-09-01},

urldate = {2024-10-28},

journal = {Diagnostics},

volume = {14},

number = {17},

pages = {1956},

abstract = {Introduction: Hematopoietic stem cell transplantation (HSCT) comprises one of the two main treatment regimens for patients with mucopolysaccharidoses (MPS). There is a scarcity of literature concerning the process of growth in children with Mucopolysaccharidosis type I (MPS I) and Mucopolysaccharidosis type I (MPS II) after HSCT. The aim of this manuscript was to evaluate the therapeutic effect of HSCT on the heights of patients with MPS I and MPS II. Material and methods: It was an observational, single-center study on patients with MPS I and II treated with HSCT. Results: 6 MPS patients, including 4 MPS I and 2 MPS II, underwent HSCT at a median age of 2 years. All patients are alive to date, with a median age of 7.7 years (range 5.5–12 years) at the last follow-up. In both (MPS I and MPS II) groups of patients treated with HSCT, the growth rate was higher than in untreated patients and was found to be in line with the population norm. In both MPS I and MPS II patients who were treated with HSCT, normalization of urinary GAG excretion was observed. Additionally, no bands of DS and HS in GAG electrophoresis were visible. Conclusions: Both MPS I and MPS II patients presented height gain after HSCT compared to the curves of untreated patients. The absence of dermatan sulphate after HSCT could lead to normal growth in bone length.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{khabbache_adaptation_2024,

title = {Adaptation and validation of the Moroccan dialect version of the nomophobia questionnaire (NMP-Q): Among university students},

author = {Hicham Khabbache and Driss Ait Ali and Abdelhalim Cherqui and Abdelaziz Allioui and Zakaria Abidli and Joumana Elturk and Murat Yildirim and Nicola Luigi Bragazzi and Gabriella Nucera and Lukasz Szarpak and Amelia Rizzo and Francesco Chirico},

url = {https://linkinghub.elsevier.com/retrieve/pii/S2405844024122876},

doi = {10.1016/j.heliyon.2024.e36256},

issn = {24058440},

year  = {2024},

date = {2024-09-01},

urldate = {2024-10-28},

journal = {Heliyon},

volume = {10},

number = {17},

pages = {e36256},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{procyk_metabolic_2024,

title = {Metabolic dysfunction-associated steatotic liver disease - A new indication for sodium-glucose Co-transporter-2 inhibitors},

author = {Grzegorz Procyk and Jakub Jaworski and Aleksandra Gąsecka and Krzysztof J. Filipiak and Josip A. Borovac},

url = {https://linkinghub.elsevier.com/retrieve/pii/S189611262400049X},

doi = {10.1016/j.advms.2024.09.001},

issn = {18961126},

year  = {2024},

date = {2024-09-01},

urldate = {2024-10-28},

journal = {Advances in Medical Sciences},

volume = {69},

number = {2},

pages = {407–415},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pruc_personalized_2024,

title = {Personalized oxygen targets are needed for extracorporeal membrane oxygenation},

author = {Michal Pruc and Michal Zembala and Monika Tomaszewska and Lukasz Szarpak},

url = {https://link.springer.com/10.1007/s00134-024-07638-7},

doi = {10.1007/s00134-024-07638-7},

issn = {0342-4642, 1432-1238},

year  = {2024},

date = {2024-09-01},

urldate = {2024-10-28},

journal = {Intensive Care Medicine},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{chmielewski_job_2024,

title = {Job burnout in a sample of Polish paramedics – role of work experience, age and health behaviours},

author = {Jarosław Chmielewski and Mariola Wojciechowska and Francesco Chirico and Pietro Crescenzo and Amelia Rizzo and Roman Starz and Murat Yıldırım and Zeynep Feride Olcay and Łukasz Szarpak and Agnieszka Strzelecka and Piotr Lutomski and Agnieszka Szarpak and Monika Tomaszewska and Tomasz Wójcik},

url = {https://www.aaem.pl/Job-burnout-in-a-sample-of-Polish-paramedics-role-of-work-experience-age-and-health,191526,0,2.html},

doi = {10.26444/aaem/191526},

issn = {1232-1966, 1898-2263},

year  = {2024},

date = {2024-09-01},

urldate = {2024-11-02},

journal = {Annals of Agricultural and Environmental Medicine},

volume = {31},

number = {3},

pages = {395–400},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{sirek_mirnas_2024,

title = {miRNAs in Signal Transduction of SMAD Proteins in Breast Cancer},

author = {Tomasz Sirek and Agata Sirek and Przemysław Borawski and Nikola Zmarzły and Joanna Sułkowska and Katarzyna Król-Jatręga and Marcin Opławski and Dariusz Boroń and Michał Chalcarz and Piotr Ossowski and Konrad Dziobek and Damian Strojny and Kacper Boroń and Dominika Janiszewska-Bil and Beniamin Oskar Grabarek},

url = {https://www.mdpi.com/1422-0067/25/18/10088},

doi = {10.3390/ijms251810088},

issn = {1422-0067},

year  = {2024},

date = {2024-09-01},

urldate = {2024-11-05},

journal = {International Journal of Molecular Sciences},

volume = {25},

number = {18},

pages = {10088},

abstract = {The aim of this study was to identify miRNAs that could potentially influence the activity of SMAD proteins involved in TGFβ signal transduction in five types of breast cancer in Polish women. Patients with five breast cancer subtypes were included in the study: luminal A (n = 130), luminal B HER2− (n = 100), luminal B HER2+ (n = 96), non-luminal HER2+ (n = 36), and TNBC (n = 43). During surgery, tumor tissue was removed along with a margin of healthy tissue (control). Molecular analysis included determination of the expression of genes related to SMAD protein signal transduction using mRNA microarrays and reverse transcription quantitative polymerase chain reaction (RT-qPCR). Protein expression was determined using an enzyme-linked immunosorbent assay (ELISA). The miRNA profiling was performed using miRNA microarrays and the miRDB database. SMAD3 and SMAD5 were overexpressed in all types of breast cancer, which could be related to the reduced expression of miR-145, and the findings for SMAD4 and miR-155 were similar. Additionally, the level of SMAD7 was reduced, which may be due to the low activity of miR-15b and miR21b. This study determined the gene expression profiles involved in SMAD protein signal transduction across five different types of breast cancer and identified the miRNAs potentially regulating their activity. Overexpression of SMAD3, SMAD4, and SMAD5 suggests excessive activation of the TGFβ pathway, potentially promoting tumor growth and development. Concurrently, a significant reduction in SMAD7 expression removes inhibitory control in the TGFβ pathway, a phenomenon that is particularly evident in more aggressive breast cancer types.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{urbanowicz_neutrophil_2024-1,

title = {Neutrophil to extracellular traps (NETs) as an early marker of right ventricular dilatation in patients with left ventricular assist devices (LVAD)},

author = {Tomasz Urbanowicz and Ewelina Wojtasińska and Anna Olasińska-Wiśniewska and Krzysztof J Filipiak and Małgorzata Ładzińska and Jędrzej Sikora and Ewa Straburzyńska-Migaj and Andrzej Tykarski and Marek Jemielity and Joanna Rupa-Matysek},

url = {https://journals.viamedica.pl/polish_heart_journal/article/view/100884},

doi = {10.33963/v.phj.100884},

issn = {1897-4279, 0022-9032},

year  = {2024},

date = {2024-08-01},

urldate = {2024-10-28},

journal = {Polish Heart Journal},

volume = {82},

number = {7-8},

pages = {777–779},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{smereka_relationship_2024,

title = {The relationship of malnutrition, frailty, and sarcopenia in critical care},

author = {Jacek Smereka and Michal Pruc and Maciej Cyran and Lukasz Szarpak},

url = {https://link.springer.com/10.1007/s00134-024-07595-1},

doi = {10.1007/s00134-024-07595-1},

issn = {0342-4642, 1432-1238},

year  = {2024},

date = {2024-08-01},

urldate = {2024-10-28},

journal = {Intensive Care Medicine},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{jaguszewski_prediction_2024,

title = {The prediction of alterations in plasma sodium levels in acutely ill patients should be more comprehensive},

author = {Milosz J. Jaguszewski and Michal Pruc and Lukasz Szarpak},

url = {https://linkinghub.elsevier.com/retrieve/pii/S0953620524003510},

doi = {10.1016/j.ejim.2024.08.013},

issn = {09536205},

year  = {2024},

date = {2024-08-01},

urldate = {2024-10-28},

journal = {European Journal of Internal Medicine},

pages = {S0953620524003510},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{macech_efficacy_2024,

title = {Efficacy of etripamil nasal spray for acute conversion of supraventricular tachycardia: a network meta-analysis},

author = {Adam Macech and Nicola Luigi Bragazzi and Francesco Chirico and Basar Cander and Michal Pruc and Zubaid Rafique and William Frank Peacock and Arash Ziapour and Lukasz Szarpak and Anna Salak and Milosz J. Jaguszewski},

url = {https://journals.viamedica.pl/cardiology_journal/article/view/100869},

doi = {10.5603/cj.100869},

issn = {1898-018X, 1897-5593},

year  = {2024},

date = {2024-08-01},

urldate = {2024-10-28},

journal = {Cardiology Journal},

volume = {31},

number = {4},

pages = {640–642},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pruc_systematic_2024,

title = {A Systematic Review and Meta-Analysis of the Diagnostic Value of Galectin-3 in Acute Coronary Syndrome},

author = {Michal Pruc and Zuzanna Gaca and Damian Swieczkowski and Jacek Kubica and Sagar Galwankar and Anna Salak and Lukasz Szarpak},

url = {https://www.mdpi.com/2077-0383/13/15/4504},

doi = {10.3390/jcm13154504},

issn = {2077-0383},

year  = {2024},

date = {2024-08-01},

urldate = {2024-10-28},

journal = {Journal of Clinical Medicine},

volume = {13},

number = {15},

pages = {4504},

abstract = {Background/Objectives: We investigated the potential diagnostic role of galectin-3 (Gal-3) in patients presenting with suspected acute coronary syndromes (ACS). Methods: We searched PubMed Central, Scopus, EMBASE, and the Cochrane Library from inception until 20 June 2024. We measured effect sizes using odds ratios (OR) with 95% CIs for dichotomous data and mean differences (MD) with CIs for continuous data. Random synthesis analysis was performed if I2 was less than 50% or Q test p values were less than 0.05. Otherwise, a fixed pooled meta-analysis was performed. Results: The meta-analysis includes 15 eligible studies. Gal-3 levels were substantially higher in the ACS group (12.84 ± 8.48 ng/mL) compared to the control group (7.23 ± 6.05 ng/mL; MD = 3.89; 95% CI: 2.83 to 4.95; p < 0.001). Gal-3 levels in acute myocardial infarction (AMI) and control groups differed (10.09 ± 8.16 vs. 4.64 ± 3.07 ng/mL},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{jankowska_modified_2024,

title = {Modified by the Innovative Drugs and Strategies—Pattern of Selected Indications for Pediatric Liver Transplantation},

author = {Irena Jankowska and Piotr Socha and Dorota Gliwicz and Patryk Lipiński and Dariusz Rokicki and Piotr Kaliciński and Ewa Danielewska and Ryszard Grenda},

url = {https://onlinelibrary.wiley.com/doi/10.1111/petr.14825},

doi = {10.1111/petr.14825},

issn = {1397-3142, 1399-3046},

year  = {2024},

date = {2024-08-01},

urldate = {2024-10-28},

journal = {Pediatric Transplantation},

volume = {28},

number = {5},

pages = {e14825},

abstract = {ABSTRACT 

 Background 

 Liver transplantation (LTx) constitutes a major life‐saving routine treatment for children with end‐stage liver disease. However, the analysis of LTx registries in children provides much information about changes in the indication profiles in the recent years. 

 Methods 

 The article provides a comprehensive review about the successes, hopes, and challenges related to changing indications for LTx in children based on the literature review and our own experience. Retrospective review of the indications for LTx at a tertiary referral pediatric hospital was also presented. 

 Results and Conclusions 

 In the context of the new therapies that have emerged, the need for LTx has decreased in patients with chronic hepatitis B and C infection and tyrosinemia type 1. In primary hyperoxaluria type 1, new RNAi‐based therapy has eliminated the requirement for LTx (both isolated or combined). There is a hope that introduction of ileal bile acid transporter (IBAT) blockers reduces the need for LTx in patients with Alagille syndrome or progressive familial intrahepatic cholestasis. The number of children qualified for LTx with urea cycle disorders (UCDs) as a prophylaxis of neurodevelopmental impairment is increasing.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pruc_diagnostic_2024,

title = {Diagnostic value of soluble urokinase‐type plasminogen activator receptor in patients with acute coronary syndrome: A systematic review and meta-analysis},

author = {Michal Pruc and Iwona Jannasz and Damian Swieczkowski and Grzegorz Procyk and Aleksandra Gasecka and Zubaid Rafique and Francesco Chirico and Nicola Luigi Bragazzi and Milosz J. Jaguszewski and Jaroslaw Wysocki and Lukasz Szarpak},

url = {https://journals.viamedica.pl/cardiology_journal/article/view/96228},

doi = {10.5603/cj.96228},

issn = {1898-018X, 1897-5593},

year  = {2024},

date = {2024-08-01},

urldate = {2024-10-28},

journal = {Cardiology Journal},

volume = {31},

number = {4},

pages = {564–572},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{urbanowicz_predictive_2024,

title = {Predictive value of systemic inflammatory response index (SIRI) for complex coronary artery disease occurrence in patients presenting with angina equivalent symptoms},

author = {Tomasz Urbanowicz and Michał Michalak and Anna Komosa and Anna Olasińska-Wiśniewska and Krzysztof J. Filipiak and Andrzej Tykarski and Marek Jemielity},

url = {https://journals.viamedica.pl/cardiology_journal/article/view/92829},

doi = {10.5603/CJ.a2023.0033},

issn = {1898-018X, 1897-5593},

year  = {2024},

date = {2024-08-01},

urldate = {2024-10-28},

journal = {Cardiology Journal},

volume = {31},

number = {4},

pages = {583–595},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{sirek_expression_2024,

title = {Expression profile of messenger and micro RNAs related to the histaminergic system in patients with five subtypes of breast cancer},

author = {Tomasz Sirek and Agata Sirek and Marcin Opławski and Dariusz Boroń and Michał Chalcarz and Piotr Ossowski and Konrad Dziobek and Nikola Zmarzły and Damian Strojny and Beniamin Oskar Grabarek},

url = {https://www.frontiersin.org/articles/10.3389/fonc.2024.1407538/full},

doi = {10.3389/fonc.2024.1407538},

issn = {2234-943X},

year  = {2024},

date = {2024-08-01},

urldate = {2024-10-28},

journal = {Frontiers in Oncology},

volume = {14},

pages = {1407538},

abstract = {Disparities in estrogen receptor (ER), progesterone receptor, human epidermal growth factor receptor 2 (HER2), and Ki67 proliferation indices facilitate the categorization of breast cancer into four principal subtypes: luminal A, luminal B, HER2-positive, and triple-negative breast cancer (TNBC). Preclinical studies investigating the therapeutic potential of histaminergic system targeting in breast cancer have shown promising results. This study aimed to assess the expression profiles of messenger ribonucleic acid (mRNA) and micro RNA (miRNA) related to the histaminergic system in five subtypes of breast cancer among Polish women. Patients with five breast cancer subtypes were included in the study: luminal A (n = 130), luminal B (n = 196, including HER2-},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{gasecka_ticagrelor_2024,

title = {Ticagrelor downregulates the expression of proatherogenic and proinflammatory miR125-b compared to clopidogrel: A randomized, controlled trial},

author = {Aleksandra Gasecka and Ewelina Błażejowska and Kinga Pluta and Magdalena Gajewska and Sylwester Rogula and Krzysztof J. Filipiak and Janusz Kochman and Jolanta M. Siller-Matula and Marek Postuła and Ceren Eyileten},

url = {https://linkinghub.elsevier.com/retrieve/pii/S0167527324006934},

doi = {10.1016/j.ijcard.2024.132073},

issn = {0167-5273},

year  = {2024},

date = {2024-07-01},

urldate = {2024-09-17},

journal = {International Journal of Cardiology},

volume = {406},

pages = {132073},

note = {Publisher: Elsevier BV},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{urbanowicz_long-term_2024,

title = {Long-Term Survival after Coronary Artery Surgical Revascularization—Does Ambient Temperature Matter?},

author = {Tomasz Urbanowicz and Krzysztof Skotak and Jakub Bratkowski and Anna Olasińska-Wiśniewska and Krzysztof J. Filipiak and Michał Michalak and Kajetan Grodecki and Krystian Szczepański and Andrzej Tykarski and Beata Krasińska and Zbigniew Krasiński and Aleksandra Krasińska-Płachta and Marek Jemielity},

url = {https://www.mdpi.com/1648-9144/60/8/1220},

doi = {10.3390/medicina60081220},

issn = {1648-9144},

year  = {2024},

date = {2024-07-01},

urldate = {2024-10-28},

journal = {Medicina},

volume = {60},

number = {8},

pages = {1220},

abstract = {Background and Objectives: The progression of global warming results in an increased exposure to extreme heat, leading to exaggeration of preexisting diseases and premature deaths. The aim of the study was to present possible risk factors for all-cause long-term mortality in patients who underwent surgical revascularization, including an assessment of the influence of ambient temperature exposure. Materials and Methods: Retrospective analysis included 153 (123 (80%) males and 30 (20%) females) patients who underwent off-pump revascularization and were followed for a median time of 2533 (1035–3250) days. The demographical, clinical data and ambient temperature exposure were taken into analysis for prediction of all-cause mortality. Individual exposure was calculated based on the place of habitation. Results: In the multivariate logistic regression model with backward stepwise elimination method, risk factors such as dyslipidaemia (p = 0.001), kidney disease (p = 0.005), age (p = 0.006), and body mass index (p = 0.007) were found to be significant for late mortality prediction. In addition to traditional factors, environmental characteristics, including tropical nights (p = 0.043), were revealed to be significant. Conclusions: High night-time ambient temperatures known as tropical nights may be regarded as additional long-term mortality risk factor after surgical revascularization.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pruc_long-term_2024,

title = {Long-term inhaled corticosteroid treatment in patients with chronic obstructive lung disease, cardiovascular disease, and recent hospitalization for exacerbation},

author = {Michal Pruc and Lukasz Szarpak},

url = {https://linkinghub.elsevier.com/retrieve/pii/S0953620524003224},

doi = {10.1016/j.ejim.2024.07.025},

issn = {09536205},

year  = {2024},

date = {2024-07-01},

urldate = {2024-10-28},

journal = {European Journal of Internal Medicine},

pages = {S0953620524003224},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{dubiela_long-_2024,

title = {Long- and Short-Term Glucosphingosine (lyso-Gb1) Dynamics in Gaucher Patients Undergoing Enzyme Replacement Therapy},

author = {Pawel Dubiela and Paulina Szymanska-Rozek and Piotr Hasinski and Patryk Lipinski and Grazina Kleinotiene and Dorota Giersz and Anna Tylki-Szymanska},

url = {https://www.mdpi.com/2218-273X/14/7/842},

doi = {10.3390/biom14070842},

issn = {2218-273X},

year  = {2024},

date = {2024-07-01},

urldate = {2024-10-28},

journal = {Biomolecules},

volume = {14},

number = {7},

pages = {842},

abstract = {Background: Gaucher disease (GD) is a lysosomal storage disorder caused by mutations in the GBA1 gene, leading to β-glucocerebrosidase deficiency and glucosylceramide accumulation. Methods: We analyzed short- and long-term dynamics of lyso-glucosylceramide (lyso-Gb1) in a large cohort of GD patients undergoing enzyme replacement therapy (ERT). Results: Eight-years analysis of lyso-Gb1 revealed statistically insignificant variability in the biomarker across the years and relatively high individual variability in patients’ results. GD type 1 (GD1) patients exhibited higher variability compared to GD type 3 (GD3) patients (coefficients of variation: 34% and 23%, respectively; p-value = 0.0003). We also investigated the short-term response of the biomarker to enzyme replacement therapy (ERT), measuring lyso-Gb1 right before and 30 min after treatment administration. We tested 20 GD patients (16 GD1, 4 GD3) and observed a rapid and significant reduction in lyso-Gb1 levels (average decrease of 17%; p-value < 0.0001). This immediate response reaffirms the efficacy of ERT in reducing substrate accumulation in GD patients but, on the other hand, suggests the biomarker’s instability between the infusions. Conclusions: These findings underscore lyso-Gb1’s potential as a reliable biomarker for monitoring efficacy of treatment. However, individual variability and dry blood spot (DBS) testing limitations urge a further refinement in clinical application. Our study contributes valuable insights into GD patient management, emphasizing the evolving role of biomarkers in personalized medicine.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}