2024
Kozikowski, Mieszko; Zagrodzka, Magdalena; Zawadzki, Marek; Zugaj, Przemysław; Osiecki, Rafał; Rzymkowski, Franciszek; Śledź, Mateusz; Sosnowski, Roman; Dobruch, Jakub; Giudice, Francesco Del; Krajewski, Wojciech
The role of VI-RADS scoring criteria for predicting oncological outcomes in bladder cancer Journal Article
In: World Journal of Urology, vol. 42, no. 1, pp. 438, 2024, ISSN: 1433-8726.
@article{kozikowski_role_2024,
title = {The role of VI-RADS scoring criteria for predicting oncological outcomes in bladder cancer},
author = {Mieszko Kozikowski and Magdalena Zagrodzka and Marek Zawadzki and Przemysław Zugaj and Rafał Osiecki and Franciszek Rzymkowski and Mateusz Śledź and Roman Sosnowski and Jakub Dobruch and Francesco Del Giudice and Wojciech Krajewski},
url = {https://link.springer.com/10.1007/s00345-024-05101-2},
doi = {10.1007/s00345-024-05101-2},
issn = {1433-8726},
year = {2024},
date = {2024-07-01},
urldate = {2024-10-28},
journal = {World Journal of Urology},
volume = {42},
number = {1},
pages = {438},
abstract = {Abstract
Purpose
Our purpose was to evaluate the prognostic value of Vesical Imaging Reporting and Data System (VI-RADS) in bladder cancer (BCa) staging and predicting recurrence or progression.
Methods
We retrospectively analyzed the prospectively collected data from 96 patients with bladder tumors who underwent VI-RADS-based multiparametric magnetic resonance imaging (mpMRI) before endourological treatment from April 2021 to December 2022. Diagnostic performance was evaluated by comparing mpMRI reports with final pathology, using logistic regression for muscle-invasive bladder cancer (MIBC) predictors. Follow-up until May 2023 included Kaplan-Meier and Cox regression analysis to assess VI-RADS predictive roles for recurrence-free survival (RFS) and progression-free survival (PFS).
Results
A total of 96 patients (19.8% women, 80.2% men; median age 68.0 years) were included, with 71% having primary tumors and 29% recurrent BCa. Multiparametric MRI exhibited high sensitivity (92%) and specificity (79%) in predicting MIBC, showing no significant differences between primary and recurrent cancers (AUC: 0.96 vs. 0.92,
P = .565). VI-RADS emerged as a key predictor for MIBC in both univariate (OR: 40.3,
P
< .001) and multivariate (OR: 54.6,
P
< .001) analyses. Primary tumors with VI-RADS ≥ 3 demonstrated significantly shorter RFS (
P = .02) and PFS (
P = .04).
Conclusions
In conclusion, mpMRI with VI-RADS has a high diagnostic value in predicting MIBC in both primary and recurrent BCa. A VI-RADS threshold ≥ 3 is a strong predictor for MIBC, and in primary tumors predicts early recurrence and progression.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Abstract
Purpose
Our purpose was to evaluate the prognostic value of Vesical Imaging Reporting and Data System (VI-RADS) in bladder cancer (BCa) staging and predicting recurrence or progression.
Methods
We retrospectively analyzed the prospectively collected data from 96 patients with bladder tumors who underwent VI-RADS-based multiparametric magnetic resonance imaging (mpMRI) before endourological treatment from April 2021 to December 2022. Diagnostic performance was evaluated by comparing mpMRI reports with final pathology, using logistic regression for muscle-invasive bladder cancer (MIBC) predictors. Follow-up until May 2023 included Kaplan-Meier and Cox regression analysis to assess VI-RADS predictive roles for recurrence-free survival (RFS) and progression-free survival (PFS).
Results
A total of 96 patients (19.8% women, 80.2% men; median age 68.0 years) were included, with 71% having primary tumors and 29% recurrent BCa. Multiparametric MRI exhibited high sensitivity (92%) and specificity (79%) in predicting MIBC, showing no significant differences between primary and recurrent cancers (AUC: 0.96 vs. 0.92,
P = .565). VI-RADS emerged as a key predictor for MIBC in both univariate (OR: 40.3,
P
< .001) and multivariate (OR: 54.6,
P
< .001) analyses. Primary tumors with VI-RADS ≥ 3 demonstrated significantly shorter RFS (
P = .02) and PFS (
P = .04).
Conclusions
In conclusion, mpMRI with VI-RADS has a high diagnostic value in predicting MIBC in both primary and recurrent BCa. A VI-RADS threshold ≥ 3 is a strong predictor for MIBC, and in primary tumors predicts early recurrence and progression.
Purpose
Our purpose was to evaluate the prognostic value of Vesical Imaging Reporting and Data System (VI-RADS) in bladder cancer (BCa) staging and predicting recurrence or progression.
Methods
We retrospectively analyzed the prospectively collected data from 96 patients with bladder tumors who underwent VI-RADS-based multiparametric magnetic resonance imaging (mpMRI) before endourological treatment from April 2021 to December 2022. Diagnostic performance was evaluated by comparing mpMRI reports with final pathology, using logistic regression for muscle-invasive bladder cancer (MIBC) predictors. Follow-up until May 2023 included Kaplan-Meier and Cox regression analysis to assess VI-RADS predictive roles for recurrence-free survival (RFS) and progression-free survival (PFS).
Results
A total of 96 patients (19.8% women, 80.2% men; median age 68.0 years) were included, with 71% having primary tumors and 29% recurrent BCa. Multiparametric MRI exhibited high sensitivity (92%) and specificity (79%) in predicting MIBC, showing no significant differences between primary and recurrent cancers (AUC: 0.96 vs. 0.92,
P = .565). VI-RADS emerged as a key predictor for MIBC in both univariate (OR: 40.3,
P
< .001) and multivariate (OR: 54.6,
P
< .001) analyses. Primary tumors with VI-RADS ≥ 3 demonstrated significantly shorter RFS (
P = .02) and PFS (
P = .04).
Conclusions
In conclusion, mpMRI with VI-RADS has a high diagnostic value in predicting MIBC in both primary and recurrent BCa. A VI-RADS threshold ≥ 3 is a strong predictor for MIBC, and in primary tumors predicts early recurrence and progression.
Płatkowska, Anna; Słowińska, Monika; Zalewska, Joanna; Swacha, Zbigniew; Szumera-Ciećkiewicz, Anna; Wągrodzki, Michał; Patera, Janusz; Łapieńska-Rey, Katarzyna; Lorent, Małgorzata; Ługowska, Iwona; Rutkowski, Piotr; Owczarek, Witold
In: Journal of Clinical Medicine, vol. 13, no. 15, pp. 4377, 2024, ISSN: 2077-0383.
@article{platkowska_minimally_2024,
title = {Minimally Invasive Plasma Device Management of Multiple Benign Skin Cancers Associated with Rare Genodermatoses—Case Series and Review of the Therapeutic Methods},
author = {Anna Płatkowska and Monika Słowińska and Joanna Zalewska and Zbigniew Swacha and Anna Szumera-Ciećkiewicz and Michał Wągrodzki and Janusz Patera and Katarzyna Łapieńska-Rey and Małgorzata Lorent and Iwona Ługowska and Piotr Rutkowski and Witold Owczarek},
url = {https://www.mdpi.com/2077-0383/13/15/4377},
doi = {10.3390/jcm13154377},
issn = {2077-0383},
year = {2024},
date = {2024-07-01},
urldate = {2024-11-05},
journal = {Journal of Clinical Medicine},
volume = {13},
number = {15},
pages = {4377},
abstract = {Background: Non-melanocytic benign skin tumours encompass a diverse group of lesions, classified based on their cellular origin, such as epidermal, vascular, fibrous, neural, muscle, and adnexal tumours. Though they often reveal solitary lesions, multiple skin tumours focus on genodermatoses. Each syndrome exhibits distinct clinical characteristics and potential complications, including cutaneous and extra-cutaneous malignancies, some of which are potentially life-threatening. Diagnosing genetic syndromes is complex and requires numerous histopathological and immunohistochemistry tests due to similarities between the adnexal tumours and basal cell carcinoma upon pathology. Methods: To illustrate the clinical practice, we conducted a retrospective case study that included eleven patients with genodermatoses referred to a tertiary dermatology clinic from September 2018 to April 2024. We have also conducted a research study on available treatment modalities in this setting. Results: Five patients with excellent aesthetic results were treated using a recently approved FDA plasma device. After searching SCOPUS and PubMed database records, we assessed 96 original articles to present current knowledge regarding the dermato-surgical approach. Conclusions: Multiple skin tumours, especially on the face, may significantly affect patients’ quality of life and have psychological consequences. An appropriate treatment selection tailored to the patient’s needs should be provided. There is no standardised treatment for multiple benign tumours in genodermatoses, and selected methods with varying efficacy are employed. We presented the utility of a new plasma device in these settings.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Background: Non-melanocytic benign skin tumours encompass a diverse group of lesions, classified based on their cellular origin, such as epidermal, vascular, fibrous, neural, muscle, and adnexal tumours. Though they often reveal solitary lesions, multiple skin tumours focus on genodermatoses. Each syndrome exhibits distinct clinical characteristics and potential complications, including cutaneous and extra-cutaneous malignancies, some of which are potentially life-threatening. Diagnosing genetic syndromes is complex and requires numerous histopathological and immunohistochemistry tests due to similarities between the adnexal tumours and basal cell carcinoma upon pathology. Methods: To illustrate the clinical practice, we conducted a retrospective case study that included eleven patients with genodermatoses referred to a tertiary dermatology clinic from September 2018 to April 2024. We have also conducted a research study on available treatment modalities in this setting. Results: Five patients with excellent aesthetic results were treated using a recently approved FDA plasma device. After searching SCOPUS and PubMed database records, we assessed 96 original articles to present current knowledge regarding the dermato-surgical approach. Conclusions: Multiple skin tumours, especially on the face, may significantly affect patients’ quality of life and have psychological consequences. An appropriate treatment selection tailored to the patient’s needs should be provided. There is no standardised treatment for multiple benign tumours in genodermatoses, and selected methods with varying efficacy are employed. We presented the utility of a new plasma device in these settings.
Farah, Raymond; Khamisy-Farah, Rola; Dziedzic, Kacper; Skrzypek, Ewa; Pruc, Michal; Bragazzi, Nicola Luigi; Szarpak, Lukasz; Jomah, Mahmoud
The role of the neutrophil-lymphocyte ratio in predicting poor outcomes in COVID-19 patients Journal Article
In: Cardiology Journal, vol. 31, no. 3, pp. 374–380, 2024, ISSN: 1898-018X, 1897-5593, (Publisher: VM Media Group sp. z o.o).
@article{farah_role_2024,
title = {The role of the neutrophil-lymphocyte ratio in predicting poor outcomes in COVID-19 patients},
author = {Raymond Farah and Rola Khamisy-Farah and Kacper Dziedzic and Ewa Skrzypek and Michal Pruc and Nicola Luigi Bragazzi and Lukasz Szarpak and Mahmoud Jomah},
url = {https://journals.viamedica.pl/cardiology_journal/article/view/98214},
doi = {10.5603/cj.98214},
issn = {1898-018X, 1897-5593},
year = {2024},
date = {2024-06-01},
urldate = {2024-09-17},
journal = {Cardiology Journal},
volume = {31},
number = {3},
pages = {374–380},
note = {Publisher: VM Media Group sp. z o.o},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Wojnar, Marcin; Wierzbiński, Piotr; Samochowiec, Jerzy; Rymaszewska, Joanna; Filipiak, Krzysztof J.; Wichniak, Adam; Mróz, Robert; Mamcarz, Artur; Dudek, Dominika
Management of nicotine dependence in patients with psychiatric disorders – recommendations of the Polish Psychiatric Association – part II Journal Article
In: Psychiatria Polska, vol. 58, no. 3, pp. 419–431, 2024, ISSN: 0033-2674, 2391-5854.
@article{wojnar_management_2024,
title = {Management of nicotine dependence in patients with psychiatric disorders – recommendations of the Polish Psychiatric Association – part II},
author = {Marcin Wojnar and Piotr Wierzbiński and Jerzy Samochowiec and Joanna Rymaszewska and Krzysztof J. Filipiak and Adam Wichniak and Robert Mróz and Artur Mamcarz and Dominika Dudek},
url = {https://www.psychiatriapolska.pl/Management-of-nicotine-dependence-in-patients-with-psychiatric-disorders-recommendations,161774,0,2.html},
doi = {10.12740/PP/OnlineFirst/161774},
issn = {0033-2674, 2391-5854},
year = {2024},
date = {2024-06-01},
urldate = {2024-10-28},
journal = {Psychiatria Polska},
volume = {58},
number = {3},
pages = {419–431},
abstract = {Rozwój metod leczenia uzależnienia od nikotyny postępuje powoli, gdyż osoby z zaburzeniami psychicznymi są zazwyczaj wykluczane z udziału w badaniach klinicznych. Istnieje szereg możliwości terapeutycznych wspomagania rzucenia palenia, obejmujących interwencje psychologiczne i farmakologiczne, które powinny być oferowane osobom z zaburzeniami psychicznymi palącymi papierosy. Pierwszym krokiem w pomaganiu osobom palącym wyroby tytoniowe i uzależnionym od nikotyny jest ocena intensywności palenia tytoniu i potwierdzenie uzależnienia od nikotyny. Aktualnie dysponujemy kilkoma formami metod leczenia uzależnienia od nikotyny – od edukacji, psychoterapii poprzez farmakoterapię i terapię zastępczą po uzyskanie stopniowych postępów z zastosowaniem metody redukcji szkód. W leczeniu farmakologicznym uzależnienia od nikotyny można wybrać nikotynową terapię zastępczą, wareniklinę lub bupropion. Zwiększenie skuteczności może być osiągnięte poprzez prowadzenie terapii antynikotynowej w ramach leczenia psychiatrycznego oraz promocji redukcji szkód jako akceptowalnego wyjściowego celu terapeutycznego. Strategia redukcji szkód jest podejściem do rozważenia indywidualnie, szczególnie w przypadku osób niezdolnych do zaprzestania palenia papierosów, pacjentów z ograniczonym wglądem chorobowym, pacjentów w zaostrzeniu choroby oraz uporczywie niewspółpracujących. W pracy przedstawiono zalecenia Polskiego Towarzystwa Psychiatrycznego odnośnie diagnostyki oraz różnych metod leczenia uzależnienia od nikotyny u pacjentów z zaburzeniami psychicznymi.
,
The development of treatment methods for nicotine dependence has progressed slowly because people with psychiatric disorders are usually excluded from participating in clinical trials. There are several therapeutic options to support smoking cessation, including psychological and pharmacological interventions, which should be offered to smokers with mental disorders. The first step in helping tobacco smokers and nicotine-dependent individuals is the assessment of smoking intensity and confirmation of nicotine dependence. Currently, we have several methods of treating nicotine dependence – starting from education and psychotherapy, through pharmacotherapy and replacement therapy, and ending up with obtaining gradual progress with the application of harm reduction. Pharmacological treatment options include nicotine replacement therapy, varenicline or bupropion. The effectiveness of such interventions can be improved by providing anti-smoking therapy under psychiatric treatment and promoting harm reduction as an acceptable initial therapeutic goal. The harm reduction strategy is an approach that should be taken into account individually, particularly in the case of individuals unable to stop smoking, patients with limited insight into their illness, patients experiencing an exacerbation of their illness and persistently uncooperative patients. In this paper, recommendations of the Polish Psychiatric Association on the diagnostics and different treatment methods for nicotine dependence in patients with psychiatric disorders are presented.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Rozwój metod leczenia uzależnienia od nikotyny postępuje powoli, gdyż osoby z zaburzeniami psychicznymi są zazwyczaj wykluczane z udziału w badaniach klinicznych. Istnieje szereg możliwości terapeutycznych wspomagania rzucenia palenia, obejmujących interwencje psychologiczne i farmakologiczne, które powinny być oferowane osobom z zaburzeniami psychicznymi palącymi papierosy. Pierwszym krokiem w pomaganiu osobom palącym wyroby tytoniowe i uzależnionym od nikotyny jest ocena intensywności palenia tytoniu i potwierdzenie uzależnienia od nikotyny. Aktualnie dysponujemy kilkoma formami metod leczenia uzależnienia od nikotyny – od edukacji, psychoterapii poprzez farmakoterapię i terapię zastępczą po uzyskanie stopniowych postępów z zastosowaniem metody redukcji szkód. W leczeniu farmakologicznym uzależnienia od nikotyny można wybrać nikotynową terapię zastępczą, wareniklinę lub bupropion. Zwiększenie skuteczności może być osiągnięte poprzez prowadzenie terapii antynikotynowej w ramach leczenia psychiatrycznego oraz promocji redukcji szkód jako akceptowalnego wyjściowego celu terapeutycznego. Strategia redukcji szkód jest podejściem do rozważenia indywidualnie, szczególnie w przypadku osób niezdolnych do zaprzestania palenia papierosów, pacjentów z ograniczonym wglądem chorobowym, pacjentów w zaostrzeniu choroby oraz uporczywie niewspółpracujących. W pracy przedstawiono zalecenia Polskiego Towarzystwa Psychiatrycznego odnośnie diagnostyki oraz różnych metod leczenia uzależnienia od nikotyny u pacjentów z zaburzeniami psychicznymi.
,
The development of treatment methods for nicotine dependence has progressed slowly because people with psychiatric disorders are usually excluded from participating in clinical trials. There are several therapeutic options to support smoking cessation, including psychological and pharmacological interventions, which should be offered to smokers with mental disorders. The first step in helping tobacco smokers and nicotine-dependent individuals is the assessment of smoking intensity and confirmation of nicotine dependence. Currently, we have several methods of treating nicotine dependence – starting from education and psychotherapy, through pharmacotherapy and replacement therapy, and ending up with obtaining gradual progress with the application of harm reduction. Pharmacological treatment options include nicotine replacement therapy, varenicline or bupropion. The effectiveness of such interventions can be improved by providing anti-smoking therapy under psychiatric treatment and promoting harm reduction as an acceptable initial therapeutic goal. The harm reduction strategy is an approach that should be taken into account individually, particularly in the case of individuals unable to stop smoking, patients with limited insight into their illness, patients experiencing an exacerbation of their illness and persistently uncooperative patients. In this paper, recommendations of the Polish Psychiatric Association on the diagnostics and different treatment methods for nicotine dependence in patients with psychiatric disorders are presented.
,
The development of treatment methods for nicotine dependence has progressed slowly because people with psychiatric disorders are usually excluded from participating in clinical trials. There are several therapeutic options to support smoking cessation, including psychological and pharmacological interventions, which should be offered to smokers with mental disorders. The first step in helping tobacco smokers and nicotine-dependent individuals is the assessment of smoking intensity and confirmation of nicotine dependence. Currently, we have several methods of treating nicotine dependence – starting from education and psychotherapy, through pharmacotherapy and replacement therapy, and ending up with obtaining gradual progress with the application of harm reduction. Pharmacological treatment options include nicotine replacement therapy, varenicline or bupropion. The effectiveness of such interventions can be improved by providing anti-smoking therapy under psychiatric treatment and promoting harm reduction as an acceptable initial therapeutic goal. The harm reduction strategy is an approach that should be taken into account individually, particularly in the case of individuals unable to stop smoking, patients with limited insight into their illness, patients experiencing an exacerbation of their illness and persistently uncooperative patients. In this paper, recommendations of the Polish Psychiatric Association on the diagnostics and different treatment methods for nicotine dependence in patients with psychiatric disorders are presented.
Charpidou, Andriani; Hardavella, Georgia; Boutsikou, Efimia; Panagiotou, Emmanouil; Simsek, Gökçen Ömeroğlu; Verbeke, Koen; Xhemalaj, Daniela; Domagała-Kulawik, Joanna
Unravelling the diagnostic pathology and molecular biomarkers in lung cancer Journal Article
In: Breathe, vol. 20, no. 2, pp. 230192, 2024, ISSN: 1810-6838, 2073-4735.
@article{charpidou_unravelling_2024,
title = {Unravelling the diagnostic pathology and molecular biomarkers in lung cancer},
author = {Andriani Charpidou and Georgia Hardavella and Efimia Boutsikou and Emmanouil Panagiotou and Gökçen Ömeroğlu Simsek and Koen Verbeke and Daniela Xhemalaj and Joanna Domagała-Kulawik},
url = {http://publications.ersnet.org/lookup/doi/10.1183/20734735.0192-2023},
doi = {10.1183/20734735.0192-2023},
issn = {1810-6838, 2073-4735},
year = {2024},
date = {2024-06-01},
urldate = {2024-10-28},
journal = {Breathe},
volume = {20},
number = {2},
pages = {230192},
abstract = {The progress in lung cancer treatment is closely interlinked with the progress in diagnostic methods. There are four steps before commencing lung cancer treatment: estimation of the patient's performance status, assessment of disease stage (tumour, node, metastasis), recognition of histological subtype, and detection of biomarkers. The resection rate in lung cancer is <30% and >70% of patients need systemic therapy, which is individually adjusted. Accurate histological diagnosis is very important and it is the basis of further molecular diagnosis. In many cases only small biopsy samples are available and the rules for their assessment are defined in this review. The use of immunochemistry with at least thyroid transcription factor 1 (TTF1) and p40 is decisive in distinction between lung adenocarcinoma and squamous cell carcinoma. Molecular diagnosis and detection of known driver mutations is necessary for introducing targeted therapy and use of multiplex gene panel assays using next-generation sequencing is recommended. Immunotherapy with checkpoint inhibitors is the second promising method of systemic therapy with best results in tumours with high programmed death-ligand 1 (PD-L1) expression on cancer cells. Finally, the determination of a full tumour pattern will be possible using artificial intelligence in the near future.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
The progress in lung cancer treatment is closely interlinked with the progress in diagnostic methods. There are four steps before commencing lung cancer treatment: estimation of the patient's performance status, assessment of disease stage (tumour, node, metastasis), recognition of histological subtype, and detection of biomarkers. The resection rate in lung cancer is <30% and >70% of patients need systemic therapy, which is individually adjusted. Accurate histological diagnosis is very important and it is the basis of further molecular diagnosis. In many cases only small biopsy samples are available and the rules for their assessment are defined in this review. The use of immunochemistry with at least thyroid transcription factor 1 (TTF1) and p40 is decisive in distinction between lung adenocarcinoma and squamous cell carcinoma. Molecular diagnosis and detection of known driver mutations is necessary for introducing targeted therapy and use of multiplex gene panel assays using next-generation sequencing is recommended. Immunotherapy with checkpoint inhibitors is the second promising method of systemic therapy with best results in tumours with high programmed death-ligand 1 (PD-L1) expression on cancer cells. Finally, the determination of a full tumour pattern will be possible using artificial intelligence in the near future.
Lipiński, Patryk; Tylki-Szymańska, Anna
The Liver and Lysosomal Storage Diseases: From Pathophysiology to Clinical Presentation, Diagnostics, and Treatment Journal Article
In: Diagnostics, vol. 14, no. 12, pp. 1299, 2024, ISSN: 2075-4418.
@article{lipinski_liver_2024,
title = {The Liver and Lysosomal Storage Diseases: From Pathophysiology to Clinical Presentation, Diagnostics, and Treatment},
author = {Patryk Lipiński and Anna Tylki-Szymańska},
url = {https://www.mdpi.com/2075-4418/14/12/1299},
doi = {10.3390/diagnostics14121299},
issn = {2075-4418},
year = {2024},
date = {2024-06-01},
urldate = {2024-10-28},
journal = {Diagnostics},
volume = {14},
number = {12},
pages = {1299},
abstract = {The liver, given its role as the central metabolic organ, is involved in many inherited metabolic disorders, including lysosomal storage diseases (LSDs). The aim of this manuscript was to provide a comprehensive overview on liver involvement in LSDs, focusing on clinical manifestation and its pathomechanisms. Gaucher disease, acid sphingomyelinase deficiency, and lysosomal acid lipase deficiency were thoroughly reviewed, with hepatic manifestation being a dominant clinical phenotype. The natural history of liver disease in the above-mentioned lysosomal disorders was delineated. The importance of Niemann–Pick type C disease as a cause of cholestatic jaundice, preceding neurological manifestation, was also highlighted. Diagnostic methods and current therapeutic management of LSDs were also discussed in the context of liver involvement.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
The liver, given its role as the central metabolic organ, is involved in many inherited metabolic disorders, including lysosomal storage diseases (LSDs). The aim of this manuscript was to provide a comprehensive overview on liver involvement in LSDs, focusing on clinical manifestation and its pathomechanisms. Gaucher disease, acid sphingomyelinase deficiency, and lysosomal acid lipase deficiency were thoroughly reviewed, with hepatic manifestation being a dominant clinical phenotype. The natural history of liver disease in the above-mentioned lysosomal disorders was delineated. The importance of Niemann–Pick type C disease as a cause of cholestatic jaundice, preceding neurological manifestation, was also highlighted. Diagnostic methods and current therapeutic management of LSDs were also discussed in the context of liver involvement.
Wojnar, Marcin; Wierzbiński, Piotr; Samochowiec, Jerzy; Rymaszewska, Joanna; Filipiak, Krzysztof J.; Wichniak, Adam; Mróz, Robert; Mamcarz, Artur; Dudek, Dominika
Management of nicotine dependence in patients with psychiatric disorders – recommendations of the Polish Psychiatric Association – part I Journal Article
In: Psychiatria Polska, vol. 58, no. 3, pp. 403–418, 2024, ISSN: 0033-2674, 2391-5854.
@article{wojnar_management_2024-1,
title = {Management of nicotine dependence in patients with psychiatric disorders – recommendations of the Polish Psychiatric Association – part I},
author = {Marcin Wojnar and Piotr Wierzbiński and Jerzy Samochowiec and Joanna Rymaszewska and Krzysztof J. Filipiak and Adam Wichniak and Robert Mróz and Artur Mamcarz and Dominika Dudek},
url = {https://www.psychiatriapolska.pl/Management-of-nicotine-dependence-in-patients-with-psychiatric-disorders-recommendations,161773,0,2.html},
doi = {10.12740/PP/OnlineFirst/161773},
issn = {0033-2674, 2391-5854},
year = {2024},
date = {2024-06-01},
urldate = {2024-10-28},
journal = {Psychiatria Polska},
volume = {58},
number = {3},
pages = {403–418},
abstract = {Palenie tytoniu i uzależnienie od nikotyny są nadal jedną z głównych przyczyn szeregu poważnych i skracających życie schorzeń somatycznych. Jednocześnie są bardziej rozpowszechnione u chorych psychicznie niż w populacji ogólnej. W niniejszej pracy, która stanowi część pierwszą rekomendacji Polskiego Towarzystwa Psychiatrycznego, przedstawiono skalę zjawiska w populacji ogólnej i wśród osób z zaburzeniami psychicznymi, kryteria rozpoznawania uzależnienia i zespołu abstynencyjnego. Omówiono wpływ palenia tytoniu i ekspozycji na dym tytoniowy na rozwój i przebieg zaburzeń psychicznych, a także na przebieg leczenia zaburzeń psychicznych, w tym interakcje nikotyny z lekami psychotropowymi. Wielu pacjentów z zaburzeniami psychicznymi jest w stanie ograniczyć palenie lub uzyskać całkowitą abstynencję, jeśli zaoferuje im się adekwatną pomoc terapeutyczną. Wbrew powszechnej opinii, zaprzestanie palenia tytoniu i leczenie uzależnienia od nikotyny nie wpływa negatywnie na objawy zaburzeń psychicznych; stan psychiczny pacjentów może ulegać poprawie w efekcie terapii antynikotynowej. Najlepsze efekty pod względem utrzymania abstynencji daje zintegrowane z leczeniem psychiatrycznym podejście łączące farmakoterapię z interwencją psychoterapeutyczną.
,
Smoking and nicotine dependence are still one of the main reasons for a number of serious and life-shortening somatic diseases. At the same time, they are more prevalent in mentally ill individuals than in the general population. This work, which constitutes the first part of recommendations of the Polish Psychiatric Association, presents the scale of the phenomenon in the general population and among people with psychiatric disorders, diagnostic criteria of nicotine dependence and nicotine withdrawal. It discusses the impact of smoking and exposure to cigarette smoke on the development and course of psychiatric disorders as well as on the treatment of psychiatric disorders, including interactions between nicotine and psychotropic medications. Many psychiatric patients can reduce smoking or achieve complete abstinence if they are offered adequate motivation and therapeutic support. Contrary to popular belief, smoking cessation and nicotine dependence treatment do not negatively affect the symptoms of psychiatric disorders; patients’ mental conditions can improve following smoking cessation therapy. The best results in terms of maintaining abstinence are achieved with a treatment approach that combines pharmacotherapy with psychotherapeutic intervention integrated into routine psychiatric care.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Palenie tytoniu i uzależnienie od nikotyny są nadal jedną z głównych przyczyn szeregu poważnych i skracających życie schorzeń somatycznych. Jednocześnie są bardziej rozpowszechnione u chorych psychicznie niż w populacji ogólnej. W niniejszej pracy, która stanowi część pierwszą rekomendacji Polskiego Towarzystwa Psychiatrycznego, przedstawiono skalę zjawiska w populacji ogólnej i wśród osób z zaburzeniami psychicznymi, kryteria rozpoznawania uzależnienia i zespołu abstynencyjnego. Omówiono wpływ palenia tytoniu i ekspozycji na dym tytoniowy na rozwój i przebieg zaburzeń psychicznych, a także na przebieg leczenia zaburzeń psychicznych, w tym interakcje nikotyny z lekami psychotropowymi. Wielu pacjentów z zaburzeniami psychicznymi jest w stanie ograniczyć palenie lub uzyskać całkowitą abstynencję, jeśli zaoferuje im się adekwatną pomoc terapeutyczną. Wbrew powszechnej opinii, zaprzestanie palenia tytoniu i leczenie uzależnienia od nikotyny nie wpływa negatywnie na objawy zaburzeń psychicznych; stan psychiczny pacjentów może ulegać poprawie w efekcie terapii antynikotynowej. Najlepsze efekty pod względem utrzymania abstynencji daje zintegrowane z leczeniem psychiatrycznym podejście łączące farmakoterapię z interwencją psychoterapeutyczną.
,
Smoking and nicotine dependence are still one of the main reasons for a number of serious and life-shortening somatic diseases. At the same time, they are more prevalent in mentally ill individuals than in the general population. This work, which constitutes the first part of recommendations of the Polish Psychiatric Association, presents the scale of the phenomenon in the general population and among people with psychiatric disorders, diagnostic criteria of nicotine dependence and nicotine withdrawal. It discusses the impact of smoking and exposure to cigarette smoke on the development and course of psychiatric disorders as well as on the treatment of psychiatric disorders, including interactions between nicotine and psychotropic medications. Many psychiatric patients can reduce smoking or achieve complete abstinence if they are offered adequate motivation and therapeutic support. Contrary to popular belief, smoking cessation and nicotine dependence treatment do not negatively affect the symptoms of psychiatric disorders; patients’ mental conditions can improve following smoking cessation therapy. The best results in terms of maintaining abstinence are achieved with a treatment approach that combines pharmacotherapy with psychotherapeutic intervention integrated into routine psychiatric care.
,
Smoking and nicotine dependence are still one of the main reasons for a number of serious and life-shortening somatic diseases. At the same time, they are more prevalent in mentally ill individuals than in the general population. This work, which constitutes the first part of recommendations of the Polish Psychiatric Association, presents the scale of the phenomenon in the general population and among people with psychiatric disorders, diagnostic criteria of nicotine dependence and nicotine withdrawal. It discusses the impact of smoking and exposure to cigarette smoke on the development and course of psychiatric disorders as well as on the treatment of psychiatric disorders, including interactions between nicotine and psychotropic medications. Many psychiatric patients can reduce smoking or achieve complete abstinence if they are offered adequate motivation and therapeutic support. Contrary to popular belief, smoking cessation and nicotine dependence treatment do not negatively affect the symptoms of psychiatric disorders; patients’ mental conditions can improve following smoking cessation therapy. The best results in terms of maintaining abstinence are achieved with a treatment approach that combines pharmacotherapy with psychotherapeutic intervention integrated into routine psychiatric care.
Pecold, Jaroslaw; Krupowies, Maciej; Pruc, Michal; Tomaszewski, Marcin; Szarpak, Lukasz; Swieczkowski, Damian; Koselak, Maciej; Bragazzi, Nicola Luigi; Al-Jeabory, Mahdi
The use of tranexamic acid in patients submitted to primary total hip and knee arthroplasty: a single-center retrospective observational study Journal Article
In: Medical Research Journal, vol. 9, no. 2, pp. 180–186, 2024, ISSN: 2451-4101, 2451-2591.
@article{pecold_use_2024,
title = {The use of tranexamic acid in patients submitted to primary total hip and knee arthroplasty: a single-center retrospective observational study},
author = {Jaroslaw Pecold and Maciej Krupowies and Michal Pruc and Marcin Tomaszewski and Lukasz Szarpak and Damian Swieczkowski and Maciej Koselak and Nicola Luigi Bragazzi and Mahdi Al-Jeabory},
url = {https://journals.viamedica.pl/medical_research_journal/article/view/99367},
doi = {10.5603/mrj.99367},
issn = {2451-4101, 2451-2591},
year = {2024},
date = {2024-06-01},
urldate = {2024-11-03},
journal = {Medical Research Journal},
volume = {9},
number = {2},
pages = {180–186},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Wilimski, Radosław; Budzianowski, Jan; Łomiak, Michał; Olasińska-Wiśniewska, Anna; Pieniak, Katarzyna; Jędrzejczyk, Szymon; Domaszk, Olaf; Chudzik, Magdalena; Filipiak, Krzysztof J.; Hiczkiewicz, Jarosław; Faron, Wojciech; Urbanowicz, Tomasz; Jemielity, Marek; Grygier, Marek; Grabowski, Marcin; Kuśmierczyk, Mariusz; Rymuza, Bartosz; Huczek, Zenon; Kochman, Janusz; Pol, Edwin Van Der; Nieuwland, Rienk; Gąsecka, Aleksandra
Extracellular Vesicles to Predict Outcomes After Transcatheter Aortic Valve Implantation – a Prospective, Multicenter Cohort Study Journal Article
In: Journal of Cardiovascular Translational Research, 2024, ISSN: 1937-5387, 1937-5395.
@article{wilimski_extracellular_2024,
title = {Extracellular Vesicles to Predict Outcomes After Transcatheter Aortic Valve Implantation – a Prospective, Multicenter Cohort Study},
author = {Radosław Wilimski and Jan Budzianowski and Michał Łomiak and Anna Olasińska-Wiśniewska and Katarzyna Pieniak and Szymon Jędrzejczyk and Olaf Domaszk and Magdalena Chudzik and Krzysztof J. Filipiak and Jarosław Hiczkiewicz and Wojciech Faron and Tomasz Urbanowicz and Marek Jemielity and Marek Grygier and Marcin Grabowski and Mariusz Kuśmierczyk and Bartosz Rymuza and Zenon Huczek and Janusz Kochman and Edwin Van Der Pol and Rienk Nieuwland and Aleksandra Gąsecka},
url = {https://link.springer.com/10.1007/s12265-024-10521-x},
doi = {10.1007/s12265-024-10521-x},
issn = {1937-5387, 1937-5395},
year = {2024},
date = {2024-05-01},
urldate = {2024-10-28},
journal = {Journal of Cardiovascular Translational Research},
abstract = {Abstract
Introduction
Transcatheter aortic valve implantation (TAVI) is an established treatment for aortic stenosis (AS) in patients at intermediate and high surgical risk. Circulating extracellular vesicles (EVs) are nanoparticles involved in cardiovascular diseases. We aimed to (i) determine the effect of TAVI on plasma concentrations of five EV subtypes and (ii) evaluate the predictive value of EVs for post-TAVI outcomes.
Methods
Blood samples were collected 1 day before TAVI and at hospital discharge. Concentrations of EVs were evaluated using flow cytometry.
Results Concentration of leukocytes EVs decreased after TAVI, compared to the measurement before (p = 0.008). Among 123 patients discharged from the hospital, 19.5% experienced MACCE during the median of 10.3 months. Increased pre-TAVI concentration of phosphatidylserine-exposing EVs was an independent predictor of MACCE in multivariable analysis (OR 5.313, 95% CI 1.164–24.258},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Abstract
Introduction
Transcatheter aortic valve implantation (TAVI) is an established treatment for aortic stenosis (AS) in patients at intermediate and high surgical risk. Circulating extracellular vesicles (EVs) are nanoparticles involved in cardiovascular diseases. We aimed to (i) determine the effect of TAVI on plasma concentrations of five EV subtypes and (ii) evaluate the predictive value of EVs for post-TAVI outcomes.
Methods
Blood samples were collected 1 day before TAVI and at hospital discharge. Concentrations of EVs were evaluated using flow cytometry.
Results Concentration of leukocytes EVs decreased after TAVI, compared to the measurement before (p = 0.008). Among 123 patients discharged from the hospital, 19.5% experienced MACCE during the median of 10.3 months. Increased pre-TAVI concentration of phosphatidylserine-exposing EVs was an independent predictor of MACCE in multivariable analysis (OR 5.313, 95% CI 1.164–24.258
Introduction
Transcatheter aortic valve implantation (TAVI) is an established treatment for aortic stenosis (AS) in patients at intermediate and high surgical risk. Circulating extracellular vesicles (EVs) are nanoparticles involved in cardiovascular diseases. We aimed to (i) determine the effect of TAVI on plasma concentrations of five EV subtypes and (ii) evaluate the predictive value of EVs for post-TAVI outcomes.
Methods
Blood samples were collected 1 day before TAVI and at hospital discharge. Concentrations of EVs were evaluated using flow cytometry.
Results Concentration of leukocytes EVs decreased after TAVI, compared to the measurement before (p = 0.008). Among 123 patients discharged from the hospital, 19.5% experienced MACCE during the median of 10.3 months. Increased pre-TAVI concentration of phosphatidylserine-exposing EVs was an independent predictor of MACCE in multivariable analysis (OR 5.313, 95% CI 1.164–24.258
Cios, Aleksandra; Ciepielak, Martyna; Lieto, Krystyna; Matak, Damian; Lewicki, Sławomir; Palusińska, Małgorzata; Stankiewicz, Wanda; Szymański, Łukasz
In: Medycyna Pracy, vol. 75, no. 2, pp. 133–141, 2024, ISSN: 0465-5893, 2353-1339.
@article{cios_extremely_2024,
title = {Extremely low-frequency electromagnetic field (ELF-EMF) induced alterations in gene expression and cytokine secretion in clear cell renal carcinoma cells},
author = {Aleksandra Cios and Martyna Ciepielak and Krystyna Lieto and Damian Matak and Sławomir Lewicki and Małgorzata Palusińska and Wanda Stankiewicz and Łukasz Szymański},
url = {https://medpr.imp.lodz.pl/Extremely-low-frequency-electromagnetic-field-ELF-EMF-induced-alterations-in-gene,186834,0,2.html},
doi = {10.13075/mp.5893.01476},
issn = {0465-5893, 2353-1339},
year = {2024},
date = {2024-05-01},
urldate = {2024-10-28},
journal = {Medycyna Pracy},
volume = {75},
number = {2},
pages = {133–141},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Pietrasik, Arkadiusz; Kurzyna, Paweł; Szwed, Piotr; Jasińska-Gniadzik, Karolina; Gąsecka, Aleksandra; Darocha, Szymona; Zieliński, Dariusz; Szarpak, Łukasz; Kochman, Janusz; Grabowski, Marcin; Opolski, Grzegorz; Torbicki, Adam; Kurzyna, Marcin
Treatment of high- and intermediate-high-risk pulmonary embolism by the Pulmonary Embolism Response Team: Focus on catheter-directed therapies Journal Article
In: Cardiology Journal, vol. 31, no. 2, pp. 215–225, 2024, ISSN: 1898-018X, 1897-5593, (Publisher: VM Media Group sp. z o.o).
@article{pietrasik_treatment_2024,
title = {Treatment of high- and intermediate-high-risk pulmonary embolism by the Pulmonary Embolism Response Team: Focus on catheter-directed therapies},
author = {Arkadiusz Pietrasik and Paweł Kurzyna and Piotr Szwed and Karolina Jasińska-Gniadzik and Aleksandra Gąsecka and Szymona Darocha and Dariusz Zieliński and Łukasz Szarpak and Janusz Kochman and Marcin Grabowski and Grzegorz Opolski and Adam Torbicki and Marcin Kurzyna},
url = {https://journals.viamedica.pl/cardiology_journal/article/view/95272},
doi = {10.5603/cj.a2023.0047},
issn = {1898-018X, 1897-5593},
year = {2024},
date = {2024-04-01},
urldate = {2024-09-17},
journal = {Cardiology Journal},
volume = {31},
number = {2},
pages = {215–225},
note = {Publisher: VM Media Group sp. z o.o},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Karbowska, Eryka; Swieczkowski, Damian; Gasecka, Aleksandra; Pruc, Michal; Safiejko, Kamil; Ladny, Jerzy R.; Kopiec, Tomasz; Jaguszewski, Milosz J.; Filipiak, Krzysztof J.; Rafique, Zubaid; Szarpak, Lukasz
Statins and the risk of pancreatic cancer: A systematic review and meta-analysis of 2,797,186 patients Journal Article
In: Cardiology Journal, vol. 31, no. 2, pp. 243–250, 2024, ISSN: 1898-018X, 1897-5593, (Publisher: VM Media Group sp. z o.o).
@article{karbowska_statins_2024,
title = {Statins and the risk of pancreatic cancer: A systematic review and meta-analysis of 2,797,186 patients},
author = {Eryka Karbowska and Damian Swieczkowski and Aleksandra Gasecka and Michal Pruc and Kamil Safiejko and Jerzy R. Ladny and Tomasz Kopiec and Milosz J. Jaguszewski and Krzysztof J. Filipiak and Zubaid Rafique and Lukasz Szarpak},
url = {https://journals.viamedica.pl/cardiology_journal/article/view/88590},
doi = {10.5603/cj.a2022.0014},
issn = {1898-018X, 1897-5593},
year = {2024},
date = {2024-04-01},
urldate = {2024-09-17},
journal = {Cardiology Journal},
volume = {31},
number = {2},
pages = {243–250},
note = {Publisher: VM Media Group sp. z o.o},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Urbanowicz, Tomasz; Rajewska-Tabor, Justyna; Olasińska-Wiśniewska, Anna; Filipiak, Krzysztof J.; Michalak, Michał; Rzesoś, Patrycja; Szot, Mateusz; Krasińska-Płachta, Aleksandra; Krasińska, Beata; Pyda, Małgorzata; Tykarski, Andrzej; Jemielity, Marek; Krasiński, Zbigniew
Demographical and Clinical Factors Predictive for Aortic Dilatation. When should we be Concerned about the Size? Journal Article
In: Reviews in Cardiovascular Medicine, vol. 25, no. 5, pp. 150, 2024, ISSN: 1530-6550.
@article{urbanowicz_demographical_2024,
title = {Demographical and Clinical Factors Predictive for Aortic Dilatation. When should we be Concerned about the Size?},
author = {Tomasz Urbanowicz and Justyna Rajewska-Tabor and Anna Olasińska-Wiśniewska and Krzysztof J. Filipiak and Michał Michalak and Patrycja Rzesoś and Mateusz Szot and Aleksandra Krasińska-Płachta and Beata Krasińska and Małgorzata Pyda and Andrzej Tykarski and Marek Jemielity and Zbigniew Krasiński},
url = {https://www.imrpress.com/journal/RCM/25/5/10.31083/j.rcm2505150},
doi = {10.31083/j.rcm2505150},
issn = {1530-6550},
year = {2024},
date = {2024-04-01},
urldate = {2024-10-28},
journal = {Reviews in Cardiovascular Medicine},
volume = {25},
number = {5},
pages = {150},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Urbanowicz, Tomasz; Hanć, Anetta; Tomczak, Jolanta; Michalak, Michał; Olasińska-Wiśniewska, Anna; Rzesoś, Patrycja; Szot, Mateusz; Filipiak, Krzysztof J.; Krasińska, Beata; Krasiński, Zbigniew; Tykarski, Andrzej; Jemielity, Marek
The Protective Effect of the Crosstalk between Zinc Hair Concentration and Lymphocyte Count—Preliminary Report Journal Article
In: Life, vol. 14, no. 5, pp. 571, 2024, ISSN: 2075-1729.
@article{urbanowicz_protective_2024,
title = {The Protective Effect of the Crosstalk between Zinc Hair Concentration and Lymphocyte Count—Preliminary Report},
author = {Tomasz Urbanowicz and Anetta Hanć and Jolanta Tomczak and Michał Michalak and Anna Olasińska-Wiśniewska and Patrycja Rzesoś and Mateusz Szot and Krzysztof J. Filipiak and Beata Krasińska and Zbigniew Krasiński and Andrzej Tykarski and Marek Jemielity},
url = {https://www.mdpi.com/2075-1729/14/5/571},
doi = {10.3390/life14050571},
issn = {2075-1729},
year = {2024},
date = {2024-04-01},
urldate = {2024-10-28},
journal = {Life},
volume = {14},
number = {5},
pages = {571},
abstract = {Background: An imbalance between pro- and anti-inflammatory mechanisms is indicated in the pathophysiology of atherosclerotic plaque. The coronary artery and carotid disease, despite sharing similar risk factors, are developed separately. The aim of this study was to analyze possible mechanisms between trace element hair–scalp concentrations and whole blood counts that favor atherosclerotic plaque progression in certain locations. Methods: There were 65 (36 (55%) males and 29 (45%) females) patients with a median age of 68 (61–73) years enrolled in a prospective, preliminary, multicenter analysis. The study group was composed of 13 patients with stable coronary artery disease (CAD group) referred for surgical revascularization due to multivessel coronary disease, 34 patients with carotid artery disease (carotid group) admitted for vascular procedure, and 18 patients in a control group (control group). Results: There was a significant difference between the CAD and carotid groups regarding lymphocyte (p = 0.004) counts. The biochemical comparison between the coronary and carotid groups revealed significant differences regarding chromium (Cr) (p = 0.002), copper (Cu) (p < 0.001), and zinc (Zn) (p < 0.001) concentrations. Spearman Rank Order Correlations between lymphocyte counts and trace elements in the analyzed groups were performed, revealing a strong correlation with zinc (R = 0.733, p < 0.001) in the control group (non-CAD, non-carotid). Conclusion: Significant differences in hair–scalp concentrations related to atherosclerosis location were observed in our analysis. The interplay between zinc concentration and lymphocyte count may play a pivotal role in cardiovascular disease development.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Background: An imbalance between pro- and anti-inflammatory mechanisms is indicated in the pathophysiology of atherosclerotic plaque. The coronary artery and carotid disease, despite sharing similar risk factors, are developed separately. The aim of this study was to analyze possible mechanisms between trace element hair–scalp concentrations and whole blood counts that favor atherosclerotic plaque progression in certain locations. Methods: There were 65 (36 (55%) males and 29 (45%) females) patients with a median age of 68 (61–73) years enrolled in a prospective, preliminary, multicenter analysis. The study group was composed of 13 patients with stable coronary artery disease (CAD group) referred for surgical revascularization due to multivessel coronary disease, 34 patients with carotid artery disease (carotid group) admitted for vascular procedure, and 18 patients in a control group (control group). Results: There was a significant difference between the CAD and carotid groups regarding lymphocyte (p = 0.004) counts. The biochemical comparison between the coronary and carotid groups revealed significant differences regarding chromium (Cr) (p = 0.002), copper (Cu) (p < 0.001), and zinc (Zn) (p < 0.001) concentrations. Spearman Rank Order Correlations between lymphocyte counts and trace elements in the analyzed groups were performed, revealing a strong correlation with zinc (R = 0.733, p < 0.001) in the control group (non-CAD, non-carotid). Conclusion: Significant differences in hair–scalp concentrations related to atherosclerosis location were observed in our analysis. The interplay between zinc concentration and lymphocyte count may play a pivotal role in cardiovascular disease development.
Safiejko, Kamil; Pedziwiatr, Michal; Pruc, Michal; Tarkowski, Radoslaw; Juchimiuk, Marcin; Domurat, Marian; Smereka, Jacek; Anvarov, Khikmat; Sielicki, Przemyslaw; Kurek, Krzysztof; Szarpak, Lukasz
Robotic versus Laparoscopic Liver Resections for Colorectal Metastases: A Systematic Review and Meta-Analysis Journal Article
In: Cancers, vol. 16, no. 8, pp. 1596, 2024, ISSN: 2072-6694.
@article{safiejko_robotic_2024,
title = {Robotic versus Laparoscopic Liver Resections for Colorectal Metastases: A Systematic Review and Meta-Analysis},
author = {Kamil Safiejko and Michal Pedziwiatr and Michal Pruc and Radoslaw Tarkowski and Marcin Juchimiuk and Marian Domurat and Jacek Smereka and Khikmat Anvarov and Przemyslaw Sielicki and Krzysztof Kurek and Lukasz Szarpak},
url = {https://www.mdpi.com/2072-6694/16/8/1596},
doi = {10.3390/cancers16081596},
issn = {2072-6694},
year = {2024},
date = {2024-04-01},
urldate = {2024-10-28},
journal = {Cancers},
volume = {16},
number = {8},
pages = {1596},
abstract = {Colorectal cancer is the third most common cancer worldwide, and the liver is the most common localization of metastatic disease. The incidence of minimally invasive liver surgery is increasing, and robotic surgery (RLR) is believed to overcome some limitations of a laparoscopic approach (LRL). We performed a systematic review and meta-analysis of operative and short-term oncologic outcomes of the laparoscopic versus robotic-assisted liver resection for colorectal liver metastases. An online search of PubMed, Embase, Scopus, and the Cochrane databases was performed. Eight studies involving 3210 patients were considered eligible for the meta-analysis. In the LRL group, a higher conversion to open rate (12.4%) was observed compared to the RLR (6.7%; p = <0.001). 30-day mortality was 0.7% for the LRL group compared to 0.5% for the RLR group (p = 0.76). Mortality in longer periods among LLR and RLR amounted to 18.2% vs. 8.0% for 1-year mortality (p = 0.07), 34.1% vs. 26.7% for 2-year mortality (p = 0.13), and 52.3% vs. 48.3% for 3-year mortality (p = 0.46). The length of hospital stay was 5.6 ± 2.5 vs. 5.8 ± 2.1 days, respectively (p = 0.47). There were no significant differences between the incidence of individual complications in the LRL and RLR groups (p = 0.78). Laparoscopic or robotic approaches for colorectal liver metastases are comparable in terms of safety and effectiveness. There are significant advantages to robotic surgery, although there is still no long-term evidence concerning overall survival, and the number of patients operated on using RLR remains small.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Colorectal cancer is the third most common cancer worldwide, and the liver is the most common localization of metastatic disease. The incidence of minimally invasive liver surgery is increasing, and robotic surgery (RLR) is believed to overcome some limitations of a laparoscopic approach (LRL). We performed a systematic review and meta-analysis of operative and short-term oncologic outcomes of the laparoscopic versus robotic-assisted liver resection for colorectal liver metastases. An online search of PubMed, Embase, Scopus, and the Cochrane databases was performed. Eight studies involving 3210 patients were considered eligible for the meta-analysis. In the LRL group, a higher conversion to open rate (12.4%) was observed compared to the RLR (6.7%; p = <0.001). 30-day mortality was 0.7% for the LRL group compared to 0.5% for the RLR group (p = 0.76). Mortality in longer periods among LLR and RLR amounted to 18.2% vs. 8.0% for 1-year mortality (p = 0.07), 34.1% vs. 26.7% for 2-year mortality (p = 0.13), and 52.3% vs. 48.3% for 3-year mortality (p = 0.46). The length of hospital stay was 5.6 ± 2.5 vs. 5.8 ± 2.1 days, respectively (p = 0.47). There were no significant differences between the incidence of individual complications in the LRL and RLR groups (p = 0.78). Laparoscopic or robotic approaches for colorectal liver metastases are comparable in terms of safety and effectiveness. There are significant advantages to robotic surgery, although there is still no long-term evidence concerning overall survival, and the number of patients operated on using RLR remains small.
Hochrainer, Nadine; Serafin, Pawel; D’Ingiullo, Sara; Mollica, Adriano; Granica, Sebastian; Brytan, Marek; Kleczkowska, Patrycja; Spetea, Mariana
In Vitro and In Vivo Pharmacological Profiles of LENART01, a Dermorphin–Ranatensin Hybrid Peptide Journal Article
In: International Journal of Molecular Sciences, vol. 25, no. 7, pp. 4007, 2024, ISSN: 1422-0067.
@article{hochrainer_vitro_2024,
title = {In Vitro and In Vivo Pharmacological Profiles of LENART01, a Dermorphin–Ranatensin Hybrid Peptide},
author = {Nadine Hochrainer and Pawel Serafin and Sara D’Ingiullo and Adriano Mollica and Sebastian Granica and Marek Brytan and Patrycja Kleczkowska and Mariana Spetea},
url = {https://www.mdpi.com/1422-0067/25/7/4007},
doi = {10.3390/ijms25074007},
issn = {1422-0067},
year = {2024},
date = {2024-04-01},
urldate = {2024-10-28},
journal = {International Journal of Molecular Sciences},
volume = {25},
number = {7},
pages = {4007},
abstract = {Diverse chemical and pharmacological strategies are currently being explored to minimize the unwanted side effects of currently used opioid analgesics while achieving effective pain relief. The use of multitarget ligands with activity at more than one receptor represents a promising therapeutic approach. We recently reported a bifunctional peptide-based hybrid LENART01 combining dermorphin and ranatensin pharmacophores, which displays activity to the mu-opioid receptor (MOR) and dopamine D2 receptor (D2R) in rat brains and spinal cords. In this study, we investigated the in vitro binding and functional activities to the human MOR and the in vivo pharmacology of LENART01 in mice after subcutaneous administration. In vitro binding assays showed LENART01 to bind and be selective to the human MOR over the other opioid receptor subtypes and delta, kappa and nociceptin receptors. In the [35S]GTPγS binding assay, LENART01 acted as a potent and full agonist to the human MOR. In mice, LENART01 produced dose-dependent antinociceptive effects in formalin-induced inflammatory pain, with increased potency than morphine. Antinociceptive effects were reversed by naloxone, indicating MOR activation in vivo. Behavioral studies also demonstrated LENART01’s properties to induce less adverse effects without locomotor dysfunction and withdrawal syndrome compared to conventional opioid analgesics, such as morphine. LENART01 is the first peptide-based MOR-D2R ligand known to date and the first dual MOR-dopamine D2R ligand for which in vivo pharmacology is reported with antinociceptive efficacy and reduced opioid-related side effects. Our current findings may pave the way to new pain therapeutics with limited side effects in acute and chronic use.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Diverse chemical and pharmacological strategies are currently being explored to minimize the unwanted side effects of currently used opioid analgesics while achieving effective pain relief. The use of multitarget ligands with activity at more than one receptor represents a promising therapeutic approach. We recently reported a bifunctional peptide-based hybrid LENART01 combining dermorphin and ranatensin pharmacophores, which displays activity to the mu-opioid receptor (MOR) and dopamine D2 receptor (D2R) in rat brains and spinal cords. In this study, we investigated the in vitro binding and functional activities to the human MOR and the in vivo pharmacology of LENART01 in mice after subcutaneous administration. In vitro binding assays showed LENART01 to bind and be selective to the human MOR over the other opioid receptor subtypes and delta, kappa and nociceptin receptors. In the [35S]GTPγS binding assay, LENART01 acted as a potent and full agonist to the human MOR. In mice, LENART01 produced dose-dependent antinociceptive effects in formalin-induced inflammatory pain, with increased potency than morphine. Antinociceptive effects were reversed by naloxone, indicating MOR activation in vivo. Behavioral studies also demonstrated LENART01’s properties to induce less adverse effects without locomotor dysfunction and withdrawal syndrome compared to conventional opioid analgesics, such as morphine. LENART01 is the first peptide-based MOR-D2R ligand known to date and the first dual MOR-dopamine D2R ligand for which in vivo pharmacology is reported with antinociceptive efficacy and reduced opioid-related side effects. Our current findings may pave the way to new pain therapeutics with limited side effects in acute and chronic use.
Sobieraj, Michał; Urbanowicz, Tomasz; Wiśniewska, Anna Olasińska –; Gładki, Marcin; Michalak, Michał; Filipiak, Krzysztof J.; Węclewska, Anita; Bartkowska-Śniatkowska, Alicja; Tykarski, Andrzej; Bobkowski, Waldemar; Jemielity, Marek
Anisocytosis as a possible predictor of low cardiac output syndrome in children undergoing mitral valve surgery Journal Article
In: Advances in Medical Sciences, vol. 69, no. 1, pp. 147–152, 2024, ISSN: 1896-1126, (Publisher: Elsevier BV).
@article{sobieraj_anisocytosis_2024,
title = {Anisocytosis as a possible predictor of low cardiac output syndrome in children undergoing mitral valve surgery},
author = {Michał Sobieraj and Tomasz Urbanowicz and Anna Olasińska – Wiśniewska and Marcin Gładki and Michał Michalak and Krzysztof J. Filipiak and Anita Węclewska and Alicja Bartkowska-Śniatkowska and Andrzej Tykarski and Waldemar Bobkowski and Marek Jemielity},
url = {https://linkinghub.elsevier.com/retrieve/pii/S1896112624000178},
doi = {10.1016/j.advms.2024.03.004},
issn = {1896-1126},
year = {2024},
date = {2024-03-01},
urldate = {2024-09-17},
journal = {Advances in Medical Sciences},
volume = {69},
number = {1},
pages = {147–152},
note = {Publisher: Elsevier BV},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Chirico, Francesco; Szarpak, Lukasz; Pruc, Michal; Rusecka, Joanna; Jannasz, Iwona; Targowski, Tomasz; Bragazzi, Nicola L.; Jankowski, Krzysztof; Rafique, Zubaid; Peacock, Frank William
Systematic review and meta-analysis of the co-occurrence of atrial fibrillation and liver transplantation: a lethal combination Journal Article
In: Disaster and Emergency Medicine Journal, vol. 9, no. 1, pp. 16–22, 2024, ISSN: 2543-5957, 2451-4691, (Publisher: VM Media Group sp. z o.o).
@article{chirico_systematic_2024,
title = {Systematic review and meta-analysis of the co-occurrence of atrial fibrillation and liver transplantation: a lethal combination},
author = {Francesco Chirico and Lukasz Szarpak and Michal Pruc and Joanna Rusecka and Iwona Jannasz and Tomasz Targowski and Nicola L. Bragazzi and Krzysztof Jankowski and Zubaid Rafique and Frank William Peacock},
url = {https://journals.viamedica.pl/disaster_and_emergency_medicine/article/view/96328},
doi = {10.5603/demj.a2023.0029},
issn = {2543-5957, 2451-4691},
year = {2024},
date = {2024-03-01},
urldate = {2024-09-17},
journal = {Disaster and Emergency Medicine Journal},
volume = {9},
number = {1},
pages = {16–22},
note = {Publisher: VM Media Group sp. z o.o},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Trojnar, Anna; Knetki-Wróblewska, Magdalena; Sobieraj, Piotr; Domagała-Kulawik, Joanna
Lung Cancer in Women—Sociodemographic, Clinical and Psychological Characteristics with Comparison to Men Journal Article
In: Journal of Clinical Medicine, vol. 13, no. 5, pp. 1450, 2024, ISSN: 2077-0383, (Publisher: MDPI AG).
@article{trojnar_lung_2024,
title = {Lung Cancer in Women—Sociodemographic, Clinical and Psychological Characteristics with Comparison to Men},
author = {Anna Trojnar and Magdalena Knetki-Wróblewska and Piotr Sobieraj and Joanna Domagała-Kulawik},
url = {https://www.mdpi.com/2077-0383/13/5/1450},
doi = {10.3390/jcm13051450},
issn = {2077-0383},
year = {2024},
date = {2024-03-01},
urldate = {2024-09-17},
journal = {Journal of Clinical Medicine},
volume = {13},
number = {5},
pages = {1450},
abstract = {(1) Background: There is a difference in the course of lung cancer between women and men. Therefore, there is a need to evaluate various factors in the patient population treated in daily practice. The purpose of this study was to analyze the clinical, sociodemographic and psychological aspects of female lung cancer. To better express the results, we compared women and men. (2) Methods: Consecutive patients with a history of lung cancer treatment admitted to the outpatient oncology clinic (Department of Lung Cancer and Chest Tumours, Maria Skłodowska-Curie National Research Institute of Oncology in Warsaw) and the Department of Internal Medicine, Pulmonary Diseases and Allergy, were enrolled. We conducted analyses of the clinical, psychological and socioeconomic factors of women with lung cancer treated in everyday practice, including a comparison with a group of men. Demographic data were collected from a self-administered questionnaire. We used the Perceived Stress Scale (PSS-10) and Acceptance of Illness Scale (AIS) questionnaires for psychological evaluation. (3) Results: A total of 100 patients with confirmed primary lung cancer with a history of treatment were enrolled in the study (50 women and 50 men). We found a significantly shorter history of smoking in the group of women; at the same time, there were no differences in the reported incidence of COPD. Despite comparable results to men on the psychological questionnaire (PSS-10, AIS), women more often reported a willingness to be supported by a psychologist or psychiatrist due to lung cancer. However, they did not decide to consult them more often than men. Immunotherapy was a significantly less frequently used method in women. (4) Conclusions: We should be more active in finding out the willingness to consult a psychologist or psychiatrist among women with lung cancer. The diagnosis of COPD should be considered more often among women due to the lack of differences in the reported incidence of COPD between men and women, despite a clear contrast in the number of pack-years.},
note = {Publisher: MDPI AG},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
(1) Background: There is a difference in the course of lung cancer between women and men. Therefore, there is a need to evaluate various factors in the patient population treated in daily practice. The purpose of this study was to analyze the clinical, sociodemographic and psychological aspects of female lung cancer. To better express the results, we compared women and men. (2) Methods: Consecutive patients with a history of lung cancer treatment admitted to the outpatient oncology clinic (Department of Lung Cancer and Chest Tumours, Maria Skłodowska-Curie National Research Institute of Oncology in Warsaw) and the Department of Internal Medicine, Pulmonary Diseases and Allergy, were enrolled. We conducted analyses of the clinical, psychological and socioeconomic factors of women with lung cancer treated in everyday practice, including a comparison with a group of men. Demographic data were collected from a self-administered questionnaire. We used the Perceived Stress Scale (PSS-10) and Acceptance of Illness Scale (AIS) questionnaires for psychological evaluation. (3) Results: A total of 100 patients with confirmed primary lung cancer with a history of treatment were enrolled in the study (50 women and 50 men). We found a significantly shorter history of smoking in the group of women; at the same time, there were no differences in the reported incidence of COPD. Despite comparable results to men on the psychological questionnaire (PSS-10, AIS), women more often reported a willingness to be supported by a psychologist or psychiatrist due to lung cancer. However, they did not decide to consult them more often than men. Immunotherapy was a significantly less frequently used method in women. (4) Conclusions: We should be more active in finding out the willingness to consult a psychologist or psychiatrist among women with lung cancer. The diagnosis of COPD should be considered more often among women due to the lack of differences in the reported incidence of COPD between men and women, despite a clear contrast in the number of pack-years.
Dabkowski, Miroslaw; Pruc, Michal; Chirico, Francesco; Bragazzi, Nicola Luigi; Szarpak, Lukasz
Impact of pandemic on use of mechanical chest compression systems Journal Article
In: The American Journal of Emergency Medicine, vol. 77, pp. 227–228, 2024, ISSN: 0735-6757, (Publisher: Elsevier BV).
@article{dabkowski_impact_2024,
title = {Impact of pandemic on use of mechanical chest compression systems},
author = {Miroslaw Dabkowski and Michal Pruc and Francesco Chirico and Nicola Luigi Bragazzi and Lukasz Szarpak},
url = {https://linkinghub.elsevier.com/retrieve/pii/S0735675723007039},
doi = {10.1016/j.ajem.2023.12.024},
issn = {0735-6757},
year = {2024},
date = {2024-03-01},
urldate = {2024-09-17},
journal = {The American Journal of Emergency Medicine},
volume = {77},
pages = {227–228},
note = {Publisher: Elsevier BV},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Dabkowski, Miroslaw; Bielski, Karol; Pruc, Michal; Kacprzyk, Dawid; Bragazzi, Nicola Luigi; Jaroszuk, Katarzyna; Kubica, Aldona; Świeczkowski, Damian; Kietlinska, Malgorzata; Szarpak, Lukasz
In: Medical Research Journal, vol. 9, no. 1, pp. 82–89, 2024, ISSN: 2451-4101, 2451-2591, (Publisher: VM Media Group sp. z o.o).
@article{dabkowski_impact_2024-1,
title = {The impact of the COVID-19 pandemic on airway management with supraglottic airway devices among out-of-hospital cardiac arrests: a systematic review and meta-analysis},
author = {Miroslaw Dabkowski and Karol Bielski and Michal Pruc and Dawid Kacprzyk and Nicola Luigi Bragazzi and Katarzyna Jaroszuk and Aldona Kubica and Damian Świeczkowski and Malgorzata Kietlinska and Lukasz Szarpak},
url = {https://journals.viamedica.pl/medical_research_journal/article/view/98670},
doi = {10.5603/mrj.98670},
issn = {2451-4101, 2451-2591},
year = {2024},
date = {2024-03-01},
urldate = {2024-09-17},
journal = {Medical Research Journal},
volume = {9},
number = {1},
pages = {82–89},
note = {Publisher: VM Media Group sp. z o.o},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Krawczyk, Artur; Kurek, Krzysztof; Pruc, Michal; Chirico, Francesco; Swieczkowski, Damian; Kubica, Jacek; Zadorozna, Zofia; Yıldırım, Murat; Szarpak, Lukasz; Bielski, Karol
A systematic review and meta-analysis of the impact of the pandemic on dispatcher-assisted cardiopulmonary resuscitation Journal Article
In: Medical Research Journal, vol. 9, no. 1, pp. 75–81, 2024, ISSN: 2451-4101, 2451-2591, (Publisher: VM Media Group sp. z o.o).
@article{krawczyk_systematic_2024,
title = {A systematic review and meta-analysis of the impact of the pandemic on dispatcher-assisted cardiopulmonary resuscitation},
author = {Artur Krawczyk and Krzysztof Kurek and Michal Pruc and Francesco Chirico and Damian Swieczkowski and Jacek Kubica and Zofia Zadorozna and Murat Yıldırım and Lukasz Szarpak and Karol Bielski},
url = {https://journals.viamedica.pl/medical_research_journal/article/view/98508},
doi = {10.5603/mrj.98508},
issn = {2451-4101, 2451-2591},
year = {2024},
date = {2024-03-01},
urldate = {2024-09-17},
journal = {Medical Research Journal},
volume = {9},
number = {1},
pages = {75–81},
note = {Publisher: VM Media Group sp. z o.o},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Wójcik, Michał; Plata-Babula, Aleksandra; Głowaczewska, Amelia; Sirek, Tomasz; Orczyk, Aneta; Małecka, Mariola; Grabarek, Beniamin Oskar
In: Cell Cycle, vol. 23, no. 4, pp. 385–404, 2024, ISSN: 1538-4101, 1551-4005, (Publisher: Informa UK Limited).
@article{wojcik_expression_2024,
title = {Expression profile of mRNAs and miRNAs related to mitogen-activated kinases in HaCaT cell culture treated with lipopolysaccharide a and adalimumab},
author = {Michał Wójcik and Aleksandra Plata-Babula and Amelia Głowaczewska and Tomasz Sirek and Aneta Orczyk and Mariola Małecka and Beniamin Oskar Grabarek},
url = {https://www.tandfonline.com/doi/full/10.1080/15384101.2024.2335051},
doi = {10.1080/15384101.2024.2335051},
issn = {1538-4101, 1551-4005},
year = {2024},
date = {2024-02-01},
urldate = {2024-09-17},
journal = {Cell Cycle},
volume = {23},
number = {4},
pages = {385–404},
note = {Publisher: Informa UK Limited},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Urbanowicz, Tomasz; Skotak, Krzysztof; Olasińska-Wiśniewska, Anna; Filipiak, Krzysztof J.; Bratkowski, Jakub; Krasińska, Beata; Krasiński, Zbigniew; Tykarski, Andrzej; Jemielity, Marek
The Interplay between Dyslipidemia and Neighboring Developments in Coronary Artery Disease Progression: A Personalized Approach Journal Article
In: Journal of Personalized Medicine, vol. 14, no. 3, pp. 237, 2024, ISSN: 2075-4426, (Publisher: MDPI AG).
@article{urbanowicz_interplay_2024,
title = {The Interplay between Dyslipidemia and Neighboring Developments in Coronary Artery Disease Progression: A Personalized Approach},
author = {Tomasz Urbanowicz and Krzysztof Skotak and Anna Olasińska-Wiśniewska and Krzysztof J. Filipiak and Jakub Bratkowski and Beata Krasińska and Zbigniew Krasiński and Andrzej Tykarski and Marek Jemielity},
url = {https://www.mdpi.com/2075-4426/14/3/237},
doi = {10.3390/jpm14030237},
issn = {2075-4426},
year = {2024},
date = {2024-02-01},
urldate = {2024-09-17},
journal = {Journal of Personalized Medicine},
volume = {14},
number = {3},
pages = {237},
abstract = {(1) Background: Estimates suggest that up to 10% of global annual cardiovascular deaths could be related to environmental factors. Not only air pollution components, but also noise exposure and climate changes, are highlighted as nontraditional causes of cardiovascular morbidity. The aim of this study was to identify possible urbanization risk factors for the progression of coronary artery disease in a group of patients with chronic coronary syndrome. (2) Method: There were 77 patients (50 (65%) males and 27 (35%) females) with a median age of 70 (60–74) years who underwent repetitive angiography due to chronic coronary syndrome between 2018 and 2022. The Gensini score was calculated for assessment of coronary artery disease advancement. Environmental factors including neighboring developments were taken into account in this analysis, including housing, commercial, and industrial developments within 300, 500, and 700 m distances (buffer) from the place of habitation. (3) Results: The multivariable analysis results for prediction of Gensini score progression in relation to 700 m buffer urbanization pointed out the significance of hyperlipidemia (OR: 4.24, 95% CI 1.34–13.39},
note = {Publisher: MDPI AG},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
(1) Background: Estimates suggest that up to 10% of global annual cardiovascular deaths could be related to environmental factors. Not only air pollution components, but also noise exposure and climate changes, are highlighted as nontraditional causes of cardiovascular morbidity. The aim of this study was to identify possible urbanization risk factors for the progression of coronary artery disease in a group of patients with chronic coronary syndrome. (2) Method: There were 77 patients (50 (65%) males and 27 (35%) females) with a median age of 70 (60–74) years who underwent repetitive angiography due to chronic coronary syndrome between 2018 and 2022. The Gensini score was calculated for assessment of coronary artery disease advancement. Environmental factors including neighboring developments were taken into account in this analysis, including housing, commercial, and industrial developments within 300, 500, and 700 m distances (buffer) from the place of habitation. (3) Results: The multivariable analysis results for prediction of Gensini score progression in relation to 700 m buffer urbanization pointed out the significance of hyperlipidemia (OR: 4.24, 95% CI 1.34–13.39
Bragazzi, Nicola Luigi; Woldegerima, Woldegebriel Assefa; Wu, Jianhong; Converti, Manlio; Szarpak, Lukasz; Crapanzano, Andrea; Odeh, Marwan; Farah, Raymond; Khamisy-Farah, Rola
In: Viruses, vol. 16, no. 3, pp. 325, 2024, ISSN: 1999-4915, (Publisher: MDPI AG).
@article{bragazzi_epidemiological_2024,
title = {Epidemiological and Clinical Characteristics of Mpox in Cisgender and Transgender Women and Non-Binary Individuals Assigned to the Female Sex at Birth: A Comprehensive, Critical Global Perspective},
author = {Nicola Luigi Bragazzi and Woldegebriel Assefa Woldegerima and Jianhong Wu and Manlio Converti and Lukasz Szarpak and Andrea Crapanzano and Marwan Odeh and Raymond Farah and Rola Khamisy-Farah},
url = {https://www.mdpi.com/1999-4915/16/3/325},
doi = {10.3390/v16030325},
issn = {1999-4915},
year = {2024},
date = {2024-02-01},
urldate = {2024-09-17},
journal = {Viruses},
volume = {16},
number = {3},
pages = {325},
abstract = {The 2022–2023 Mpox multi-country outbreak, identified in over 110 WHO Member States, revealed a predominant impact on cisgender men, particularly those engaging in sex with men, while less frequently affecting women. This disparity prompted a focused investigation into the gender-specific characteristics of Mpox infections, particularly among women, to address a notable knowledge gap. This review systematically gathers and analyzes the scientific literature and case reports concerning Mpox infections in women, covering a broad geographical spectrum including regions such as Argentina, Brazil, Colombia, Nigeria, Europe, Vietnam, and the United States. The analysis delves into various aspects of Mpox in women, including clinical features, epidemiology, psychological impacts, preparedness strategies, and case studies, with particular attention to pregnant women and those with underlying health conditions. Empirical data from multiple studies underscore the unique epidemiological and clinical patterns of Mpox in women. In the United States, a small percentage of Mpox cases were reported among cisgender women, with a notable portion involving non-Hispanic Black or African American, non-Hispanic White, and Hispanic or Latino ethnicities. The primary transmission route was identified as sexual or close intimate contact, with the virus predominantly manifesting on the legs, arms, and genital areas. Further, a study in Spain highlighted significant disparities in diagnosis delays, transmission modes, and clinical manifestations between genders, indicating a different risk profile and disease progression in women. Additionally, a case from Vietnam, linked to a new Mpox sub-lineage in women, emphasized the role of women in the transmission dynamics and the importance of genomic monitoring. This review emphasizes the necessity for inclusive surveillance and research to fully understand Mpox dynamics across diverse population groups, including women. Highlighting gender and sexual orientation in public health responses is crucial for an effective approach to managing the spread and impact of this disease. The findings advocate for a gender-diverse assessment in health services and further research to explore the nuances of Mpox transmission, behavior, and progression among different groups, thereby enhancing the global response to Mpox and similar public health challenges.},
note = {Publisher: MDPI AG},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
The 2022–2023 Mpox multi-country outbreak, identified in over 110 WHO Member States, revealed a predominant impact on cisgender men, particularly those engaging in sex with men, while less frequently affecting women. This disparity prompted a focused investigation into the gender-specific characteristics of Mpox infections, particularly among women, to address a notable knowledge gap. This review systematically gathers and analyzes the scientific literature and case reports concerning Mpox infections in women, covering a broad geographical spectrum including regions such as Argentina, Brazil, Colombia, Nigeria, Europe, Vietnam, and the United States. The analysis delves into various aspects of Mpox in women, including clinical features, epidemiology, psychological impacts, preparedness strategies, and case studies, with particular attention to pregnant women and those with underlying health conditions. Empirical data from multiple studies underscore the unique epidemiological and clinical patterns of Mpox in women. In the United States, a small percentage of Mpox cases were reported among cisgender women, with a notable portion involving non-Hispanic Black or African American, non-Hispanic White, and Hispanic or Latino ethnicities. The primary transmission route was identified as sexual or close intimate contact, with the virus predominantly manifesting on the legs, arms, and genital areas. Further, a study in Spain highlighted significant disparities in diagnosis delays, transmission modes, and clinical manifestations between genders, indicating a different risk profile and disease progression in women. Additionally, a case from Vietnam, linked to a new Mpox sub-lineage in women, emphasized the role of women in the transmission dynamics and the importance of genomic monitoring. This review emphasizes the necessity for inclusive surveillance and research to fully understand Mpox dynamics across diverse population groups, including women. Highlighting gender and sexual orientation in public health responses is crucial for an effective approach to managing the spread and impact of this disease. The findings advocate for a gender-diverse assessment in health services and further research to explore the nuances of Mpox transmission, behavior, and progression among different groups, thereby enhancing the global response to Mpox and similar public health challenges.
Kurek, Krzysztof; Tomaszewska, Monika; Pruc, Michał; Szarpak, Lukasz
Role of neuron-specific enolase as a prognostic marker in pediatric cardiac arrest Journal Article
In: The American Journal of Emergency Medicine, vol. 76, pp. 258–260, 2024, ISSN: 0735-6757, (Publisher: Elsevier BV).
@article{kurek_role_2024,
title = {Role of neuron-specific enolase as a prognostic marker in pediatric cardiac arrest},
author = {Krzysztof Kurek and Monika Tomaszewska and Michał Pruc and Lukasz Szarpak},
url = {https://linkinghub.elsevier.com/retrieve/pii/S0735675723006563},
doi = {10.1016/j.ajem.2023.11.043},
issn = {0735-6757},
year = {2024},
date = {2024-02-01},
urldate = {2024-09-17},
journal = {The American Journal of Emergency Medicine},
volume = {76},
pages = {258–260},
note = {Publisher: Elsevier BV},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Chalcarz, Michał; Grabarek, Beniamin Oskar; Mezer, Mateusz De; Krokowicz, Piotr; Patera, Janusz; Czupryna, Krzysztof; Żurawski, Jakub
Serum Selenium Concentration as a Potential Diagnostic Marker for Early-Stage Colorectal Cancer: A Comparative Study Journal Article
In: Medical Science Monitor, vol. 30, 2024, ISSN: 1643-3750, (Publisher: International Scientific Information, Inc.).
@article{chalcarz_serum_2024,
title = {Serum Selenium Concentration as a Potential Diagnostic Marker for Early-Stage Colorectal Cancer: A Comparative Study},
author = {Michał Chalcarz and Beniamin Oskar Grabarek and Mateusz De Mezer and Piotr Krokowicz and Janusz Patera and Krzysztof Czupryna and Jakub Żurawski},
url = {https://www.medscimonit.com/abstract/index/idArt/942882},
doi = {10.12659/msm.942882},
issn = {1643-3750},
year = {2024},
date = {2024-02-01},
urldate = {2024-09-17},
journal = {Medical Science Monitor},
volume = {30},
note = {Publisher: International Scientific Information, Inc.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Marlęga-Linert, Joanna; Gąsecka, Aleksandra; Pol, Edwin Van Der; Kuchta, Agnieszka; Filipiak, Krzysztof J.; Fijałkowski, Marcin; Gruchała, Marcin; Nieuwland, Rienk; Mickiewicz, Agnieszka
Lipoprotein apheresis affects the concentration of extracellular vesicles in patients with elevated lipoprotein (a) Journal Article
In: Scientific Reports, vol. 14, no. 1, 2024, ISSN: 2045-2322, (Publisher: Springer Science and Business Media LLC).
@article{marlega-linert_lipoprotein_2024,
title = {Lipoprotein apheresis affects the concentration of extracellular vesicles in patients with elevated lipoprotein (a)},
author = {Joanna Marlęga-Linert and Aleksandra Gąsecka and Edwin Van Der Pol and Agnieszka Kuchta and Krzysztof J. Filipiak and Marcin Fijałkowski and Marcin Gruchała and Rienk Nieuwland and Agnieszka Mickiewicz},
url = {https://www.nature.com/articles/s41598-024-51782-5},
doi = {10.1038/s41598-024-51782-5},
issn = {2045-2322},
year = {2024},
date = {2024-02-01},
urldate = {2024-09-17},
journal = {Scientific Reports},
volume = {14},
number = {1},
abstract = {AbstractLipoprotein apheresis (LA) is a therapeutic option for hyperlipoproteinemia(a) (hyper-Lp(a)) and atherosclerotic cardiovascular disease (ASCVD). LA improves blood rheology, reduces oxidative stress parameters and improves endothelial function. The underlying molecular mechanisms of LA beneficial effects are unknown, but it has been suggested that LA exhibits multiple activities beyond simply removing lipoproteins. We hypothesized that LA removes not only lipoproteins, but also extracellular vesicles (EVs). To test this hypothesis, we performed a prospective study in 22 patients undergoing LA for hyper-Lp(a) and ASCVD. Different EVs subtypes were measured before and directly after LA, and after 7 days. We used calibrated flow cytometry to detect total particle concentration (diameter > textasciitilde 100 nm), total lipoproteins concentration (diameter > 200 nm, RI > 1.51), total EV concentration (diameter > 200 nm, RI < 1.41), concentrations of EVs derived from erythrocytes (CD235a+; diameter > 200 nm, RI < 1.41), leukocytes (CD45+; diameter > 200 nm, RI < 1.41) and platelets (CD61+, PEVs; diameter > 200 nm, RI < 1.41). LA reduced the concentrations of all investigated EVs subtypes and lipoproteins. Lp(a) concentration was lowered by 64.5% [(58% – 71%); p < 0.001]. Plasma concentrations of EVs > 200 nm in diameter derived from platelets (CD61 +), leukocytes (CD45+) and erythrocytes (CD235a+) decreased after single LA procedure by 42.7% [(12.8–54.7); p = 0.005], 42.6% [(29.7–54.1); p = 0.030] and 26.7% [(1.0–62.7); p = 0.018], respectively, compared to baseline. All EV subtypes returned to the baseline concentrations in blood plasma after 7 days. To conclude, LA removes not only Lp(a), but also cell-derived EVs, which may contribute to LA beneficial effects.},
note = {Publisher: Springer Science and Business Media LLC},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
AbstractLipoprotein apheresis (LA) is a therapeutic option for hyperlipoproteinemia(a) (hyper-Lp(a)) and atherosclerotic cardiovascular disease (ASCVD). LA improves blood rheology, reduces oxidative stress parameters and improves endothelial function. The underlying molecular mechanisms of LA beneficial effects are unknown, but it has been suggested that LA exhibits multiple activities beyond simply removing lipoproteins. We hypothesized that LA removes not only lipoproteins, but also extracellular vesicles (EVs). To test this hypothesis, we performed a prospective study in 22 patients undergoing LA for hyper-Lp(a) and ASCVD. Different EVs subtypes were measured before and directly after LA, and after 7 days. We used calibrated flow cytometry to detect total particle concentration (diameter > textasciitilde 100 nm), total lipoproteins concentration (diameter > 200 nm, RI > 1.51), total EV concentration (diameter > 200 nm, RI < 1.41), concentrations of EVs derived from erythrocytes (CD235a+; diameter > 200 nm, RI < 1.41), leukocytes (CD45+; diameter > 200 nm, RI < 1.41) and platelets (CD61+, PEVs; diameter > 200 nm, RI < 1.41). LA reduced the concentrations of all investigated EVs subtypes and lipoproteins. Lp(a) concentration was lowered by 64.5% [(58% – 71%); p < 0.001]. Plasma concentrations of EVs > 200 nm in diameter derived from platelets (CD61 +), leukocytes (CD45+) and erythrocytes (CD235a+) decreased after single LA procedure by 42.7% [(12.8–54.7); p = 0.005], 42.6% [(29.7–54.1); p = 0.030] and 26.7% [(1.0–62.7); p = 0.018], respectively, compared to baseline. All EV subtypes returned to the baseline concentrations in blood plasma after 7 days. To conclude, LA removes not only Lp(a), but also cell-derived EVs, which may contribute to LA beneficial effects.
Puce, Luca; Biz, Carlo; Ceylan, Halil Ibrahim; Bragazzi, Nicola Luigi; Formica, Matteo; Trabelsi, Khaled; Szarpak, Łukasz; Trompetto, Carlo; Rossin, Alessandro; Lanciano, Nicola Antonio; Ruggieri, Pietro
Adaptive Shooting Disciplines: A Scoping Review of the Literature with Bibliometric Analysis Journal Article
In: Healthcare, vol. 12, no. 4, pp. 463, 2024, ISSN: 2227-9032, (Publisher: MDPI AG).
@article{puce_adaptive_2024,
title = {Adaptive Shooting Disciplines: A Scoping Review of the Literature with Bibliometric Analysis},
author = {Luca Puce and Carlo Biz and Halil Ibrahim Ceylan and Nicola Luigi Bragazzi and Matteo Formica and Khaled Trabelsi and Łukasz Szarpak and Carlo Trompetto and Alessandro Rossin and Nicola Antonio Lanciano and Pietro Ruggieri},
url = {https://www.mdpi.com/2227-9032/12/4/463},
doi = {10.3390/healthcare12040463},
issn = {2227-9032},
year = {2024},
date = {2024-02-01},
urldate = {2024-09-17},
journal = {Healthcare},
volume = {12},
number = {4},
pages = {463},
abstract = {Para-archery and para-shooting, two very popular adaptive shooting disciplines that have earned their place as major official events in the Paralympic Games, share some similarities, as well as distinctive features in terms of rules, physiological requirements, and equipment used. The International Paralympic Committee has a clear responsibility to ensure that all sports within its jurisdiction, including adaptive shooting, can achieve excellence in their respective fields. To achieve this, the conduct of well-designed studies and rigorous research is essential. Although some research has been conducted in this area, a comprehensive and systematic evaluation is still needed. Therefore, the present study aims to provide a thorough review and synthesis of existing research on adaptive shooting disciplines, identify strengths and gaps, and suggest future directions. Arksey and O’Malley’s methodology is leveraged and enhanced with bibliometric and policy analyses to review literature on adaptive shooting. Databases like PubMed/MEDLINE, Scopus, Web of Science, OvidSP, and EMBASE were searched, focusing on studies in adaptive shooting disciplines and analysing these findings through a blend of thematic and statistical methods. Twenty-four studies totalling 483 para-athletes (299 para-shooters and 184 para-archers) are included in this scoping review, focusing on a range of aspects, including physiological responses (n = 9), research design and measurement methods for evidence-based classification (n = 6), biopsychosocial aspects (n = 3), development of new methods and technologies (n = 4), kinematic and biomechanical assessment (n = 1), and epidemiology of injuries (n = 1). Seven articles focused exclusively on para-archery, thirteen exclusively on para-shooting, and four on both para-archery and para-shooting. In conclusion, the available literature on adaptive shooting disciplines is still very limited, especially regarding para-archery compared to para-shooting. This highlights the need for further research in many key areas to ensure a better understanding of the different disciplines and to provide appropriate support for para-athletes. Future research in para-archery and para-shooting should focus on technological innovations, biomechanical studies, and psychological support to enhance athlete performance and accessibility. Addressing the imbalance between the two disciplines, along with injury prevention and global participation, can drive the sports towards greater inclusivity and equity for para-athletes worldwide.},
note = {Publisher: MDPI AG},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Para-archery and para-shooting, two very popular adaptive shooting disciplines that have earned their place as major official events in the Paralympic Games, share some similarities, as well as distinctive features in terms of rules, physiological requirements, and equipment used. The International Paralympic Committee has a clear responsibility to ensure that all sports within its jurisdiction, including adaptive shooting, can achieve excellence in their respective fields. To achieve this, the conduct of well-designed studies and rigorous research is essential. Although some research has been conducted in this area, a comprehensive and systematic evaluation is still needed. Therefore, the present study aims to provide a thorough review and synthesis of existing research on adaptive shooting disciplines, identify strengths and gaps, and suggest future directions. Arksey and O’Malley’s methodology is leveraged and enhanced with bibliometric and policy analyses to review literature on adaptive shooting. Databases like PubMed/MEDLINE, Scopus, Web of Science, OvidSP, and EMBASE were searched, focusing on studies in adaptive shooting disciplines and analysing these findings through a blend of thematic and statistical methods. Twenty-four studies totalling 483 para-athletes (299 para-shooters and 184 para-archers) are included in this scoping review, focusing on a range of aspects, including physiological responses (n = 9), research design and measurement methods for evidence-based classification (n = 6), biopsychosocial aspects (n = 3), development of new methods and technologies (n = 4), kinematic and biomechanical assessment (n = 1), and epidemiology of injuries (n = 1). Seven articles focused exclusively on para-archery, thirteen exclusively on para-shooting, and four on both para-archery and para-shooting. In conclusion, the available literature on adaptive shooting disciplines is still very limited, especially regarding para-archery compared to para-shooting. This highlights the need for further research in many key areas to ensure a better understanding of the different disciplines and to provide appropriate support for para-athletes. Future research in para-archery and para-shooting should focus on technological innovations, biomechanical studies, and psychological support to enhance athlete performance and accessibility. Addressing the imbalance between the two disciplines, along with injury prevention and global participation, can drive the sports towards greater inclusivity and equity for para-athletes worldwide.
Borghi, Claudio; Domienik-Karłowicz, Justyna; Tykarski, Andrzej; Filipiak, Krzysztof J.; Jaguszewski, Milosz J.; Narkiewicz, Krzysztof; Barylski, Marcin; Mamcarz, Artur; Wolf, Jacek; Mancia, Giuseppe
Expert consensus for the diagnosis and treatment of patients with hyperuricemia and high cardiovascular risk: 2023 update Journal Article
In: Cardiology Journal, vol. 31, no. 1, pp. 1–14, 2024, ISSN: 1898-018X, 1897-5593.
@article{borghi_expert_2024,
title = {Expert consensus for the diagnosis and treatment of patients with hyperuricemia and high cardiovascular risk: 2023 update},
author = {Claudio Borghi and Justyna Domienik-Karłowicz and Andrzej Tykarski and Krzysztof J. Filipiak and Milosz J. Jaguszewski and Krzysztof Narkiewicz and Marcin Barylski and Artur Mamcarz and Jacek Wolf and Giuseppe Mancia},
url = {https://journals.viamedica.pl/cardiology_journal/article/view/98254},
doi = {10.5603/cj.98254},
issn = {1898-018X, 1897-5593},
year = {2024},
date = {2024-02-01},
urldate = {2024-10-28},
journal = {Cardiology Journal},
volume = {31},
number = {1},
pages = {1–14},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Jonik, Szymon; Marchel, Michał; Pędzich-Placha, Ewa; Pietrasik, Arkadiusz; Rdzanek, Adam; Huczek, Zenon; Kochman, Janusz; Budnik, Monika; Piątkowski, Radosław; Scisło, Piotr; Kochanowski, Janusz; Czub, Paweł; Wilimski, Radosław; Hendzel, Piotr; Grabowski, Marcin; Filipiak, Krzysztof J.; Opolski, Grzegorz; Mazurek, Tomasz
In: Cardiology Journal, vol. 31, no. 1, pp. 62–71, 2024, ISSN: 1898-018X, 1897-5593.
@article{jonik_long-term_2024,
title = {Long-term outcomes and quality of life following implementation of dedicated mitral valve Heart Team decisions for patients with severe mitral valve regurgitation in tertiary cardiovascular care center},
author = {Szymon Jonik and Michał Marchel and Ewa Pędzich-Placha and Arkadiusz Pietrasik and Adam Rdzanek and Zenon Huczek and Janusz Kochman and Monika Budnik and Radosław Piątkowski and Piotr Scisło and Janusz Kochanowski and Paweł Czub and Radosław Wilimski and Piotr Hendzel and Marcin Grabowski and Krzysztof J. Filipiak and Grzegorz Opolski and Tomasz Mazurek},
url = {https://journals.viamedica.pl/cardiology_journal/article/view/85100},
doi = {10.5603/CJ.a2022.0011},
issn = {1898-018X, 1897-5593},
year = {2024},
date = {2024-02-01},
urldate = {2024-10-28},
journal = {Cardiology Journal},
volume = {31},
number = {1},
pages = {62–71},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Mokros, Łukasz; Rawska-Kabacińska, Aleksandra; Świtaj, Piotr; Wieczorek, Łukasz; Jabłońska, Anna; Anczewska, Marta
Adaptation and validation of the Columbia-Suicide Severity Rating Scale (C-SSRS) - screen version Journal Article
In: Psychiatria Polska, pp. 1–18, 2024, ISSN: 0033-2674, 2391-5854.
@article{mokros_adaptation_2024,
title = {Adaptation and validation of the Columbia-Suicide Severity Rating Scale (C-SSRS) - screen version},
author = {Łukasz Mokros and Aleksandra Rawska-Kabacińska and Piotr Świtaj and Łukasz Wieczorek and Anna Jabłońska and Marta Anczewska},
url = {https://www.psychiatriapolska.pl/Adaptation-and-validation-of-the-Columbia-Suicide-Severity-Rating-Scale-C-SSRS-screen,174591,0,2.html},
doi = {10.12740/PP/OnlineFirst/174591},
issn = {0033-2674, 2391-5854},
year = {2024},
date = {2024-02-01},
urldate = {2024-10-28},
journal = {Psychiatria Polska},
pages = {1–18},
abstract = {Cel pracy
Przeprowadzenie polskiej adaptacji i psychometrycznej walidacji wersji przesiewowej Skali Oceny Ryzyka Samobójstwa z Uniwersytetu Columbia (Columbia-Suicide Severity Rating Scale - C-SSRS), wśród pacjentów przyjętych do szpitala psychiatrycznego.
Metoda
Badanie jednoośrodkowe, obserwacyjne i przekrojowe. Po przyjęciu do stacjonarnego (ostrego) oddziału psychiatrycznego 318 kolejnych pacjentów wypełniło zestaw kwestionariuszy, który składał się z wersji przesiewowej Skali Oceny Ryzyka Samobójstwa z Uniwersytetu Columbia (C-SSRS) oraz narzędzi referencyjnych: Zrewidowanego Kwestionariusza Zachowań Samobójczych (SBQ-R), Skali Atrybucji Myśli Samobójczych (SIDAS), Zrewidowanej Skali Depresji Centrum Badań Epidemiologicznych (CESD-R), Skali Bólu Psychicznego, Skali Poczucia Sensu Życia (PIL) oraz testu przesiewowego nadużywania alkoholu (CAGE).
Wyniki Współczynnik α Cronbacha dla polskiej wersji C-SSRS wynosił 0,89. W analizie czynnikowej zidentyfikowano dwa czynniki latentne: (1) myśli, zamiary i plany samobójcze oraz (2) próby samobójcze w wywiadzie. Wystąpiły różnice w średnich wynikach wszystkich zastosowanych kwestionariuszy (mianowicie SBQ-R, Skali Bólu Psychicznego, CAGE, SIDAS, PIL i CESD-R) pomiędzy grupami ryzyka wg C-SSRS (p=0,01). Ryzyko samobójstwa wg C-SSRS miało związek z kategorią rozpoznania psychiatrycznego wg ICD-10 (p<0,001).
Wnioski
Polska wersja przesiewowej Skali Oceny Ryzyka Samobójstwa z Uniwersytetu Columbia (C-SSRS) jest narzędziem o dobrych właściwościach psychometrycznych. Może służyć do oceny ryzyka samobójstwa wśród pacjentów hospitalizowanych psychiatrycznie.
,
Objectives
To perform an adaptation and psychometric validation of the Polish version of the Columbia-Suicide Severity Rating Scale (C-SSRS) screen version in a clinical sample of patients admitted to the psychiatric hospital.
Methods
This was a single-center, observational and cross-sectional study. A total of 318 consecutive patients completed a set of questionnaires upon their admission to acute psychiatric units. The set comprised C-SSRS screener and the reference measures: the Suicidal Behaviors Questionnaire – Revised (SBQ-R), the Suicidal Ideation Attributes Scale (SIDAS), the Center of Epidemiological Studies Depression Scale – Revised (CESD-R), the Scale of Psychache, the Purpose in Life scale (PIL), and alcohol misuse screen test (CAGE).
Results Cronbach’s α of the C-SSRS was 0.89. Two latent components were identified in the factor analysis: (1) suicidal thoughts, intentions and plans, and (2) history of suicidal attempts. There were differences in the mean scores of all the utilized questionnaires (namely, SBQ-R, the Psychache scale, CAGE, SIDAS, PIL and CESD-R) between the C-SSRS risk groups (p=0.01). The C-SSRS risk group was associated with the category of the primary psychiatric diagnosis (p<0.001).
Conclusions
The Polish version of the Columbia-Suicide Severity Rating Scale screener is a questionnaire with good psychometric features to assess the suicidal risk among psychiatric in-patients. It can be used for the purposes of a routine assessment of suicidal risk among hospitalized patients.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Cel pracy
Przeprowadzenie polskiej adaptacji i psychometrycznej walidacji wersji przesiewowej Skali Oceny Ryzyka Samobójstwa z Uniwersytetu Columbia (Columbia-Suicide Severity Rating Scale - C-SSRS), wśród pacjentów przyjętych do szpitala psychiatrycznego.
Metoda
Badanie jednoośrodkowe, obserwacyjne i przekrojowe. Po przyjęciu do stacjonarnego (ostrego) oddziału psychiatrycznego 318 kolejnych pacjentów wypełniło zestaw kwestionariuszy, który składał się z wersji przesiewowej Skali Oceny Ryzyka Samobójstwa z Uniwersytetu Columbia (C-SSRS) oraz narzędzi referencyjnych: Zrewidowanego Kwestionariusza Zachowań Samobójczych (SBQ-R), Skali Atrybucji Myśli Samobójczych (SIDAS), Zrewidowanej Skali Depresji Centrum Badań Epidemiologicznych (CESD-R), Skali Bólu Psychicznego, Skali Poczucia Sensu Życia (PIL) oraz testu przesiewowego nadużywania alkoholu (CAGE).
Wyniki Współczynnik α Cronbacha dla polskiej wersji C-SSRS wynosił 0,89. W analizie czynnikowej zidentyfikowano dwa czynniki latentne: (1) myśli, zamiary i plany samobójcze oraz (2) próby samobójcze w wywiadzie. Wystąpiły różnice w średnich wynikach wszystkich zastosowanych kwestionariuszy (mianowicie SBQ-R, Skali Bólu Psychicznego, CAGE, SIDAS, PIL i CESD-R) pomiędzy grupami ryzyka wg C-SSRS (p=0,01). Ryzyko samobójstwa wg C-SSRS miało związek z kategorią rozpoznania psychiatrycznego wg ICD-10 (p<0,001).
Wnioski
Polska wersja przesiewowej Skali Oceny Ryzyka Samobójstwa z Uniwersytetu Columbia (C-SSRS) jest narzędziem o dobrych właściwościach psychometrycznych. Może służyć do oceny ryzyka samobójstwa wśród pacjentów hospitalizowanych psychiatrycznie.
,
Objectives
To perform an adaptation and psychometric validation of the Polish version of the Columbia-Suicide Severity Rating Scale (C-SSRS) screen version in a clinical sample of patients admitted to the psychiatric hospital.
Methods
This was a single-center, observational and cross-sectional study. A total of 318 consecutive patients completed a set of questionnaires upon their admission to acute psychiatric units. The set comprised C-SSRS screener and the reference measures: the Suicidal Behaviors Questionnaire – Revised (SBQ-R), the Suicidal Ideation Attributes Scale (SIDAS), the Center of Epidemiological Studies Depression Scale – Revised (CESD-R), the Scale of Psychache, the Purpose in Life scale (PIL), and alcohol misuse screen test (CAGE).
Results Cronbach’s α of the C-SSRS was 0.89. Two latent components were identified in the factor analysis: (1) suicidal thoughts, intentions and plans, and (2) history of suicidal attempts. There were differences in the mean scores of all the utilized questionnaires (namely, SBQ-R, the Psychache scale, CAGE, SIDAS, PIL and CESD-R) between the C-SSRS risk groups (p=0.01). The C-SSRS risk group was associated with the category of the primary psychiatric diagnosis (p<0.001).
Conclusions
The Polish version of the Columbia-Suicide Severity Rating Scale screener is a questionnaire with good psychometric features to assess the suicidal risk among psychiatric in-patients. It can be used for the purposes of a routine assessment of suicidal risk among hospitalized patients.
Przeprowadzenie polskiej adaptacji i psychometrycznej walidacji wersji przesiewowej Skali Oceny Ryzyka Samobójstwa z Uniwersytetu Columbia (Columbia-Suicide Severity Rating Scale - C-SSRS), wśród pacjentów przyjętych do szpitala psychiatrycznego.
Metoda
Badanie jednoośrodkowe, obserwacyjne i przekrojowe. Po przyjęciu do stacjonarnego (ostrego) oddziału psychiatrycznego 318 kolejnych pacjentów wypełniło zestaw kwestionariuszy, który składał się z wersji przesiewowej Skali Oceny Ryzyka Samobójstwa z Uniwersytetu Columbia (C-SSRS) oraz narzędzi referencyjnych: Zrewidowanego Kwestionariusza Zachowań Samobójczych (SBQ-R), Skali Atrybucji Myśli Samobójczych (SIDAS), Zrewidowanej Skali Depresji Centrum Badań Epidemiologicznych (CESD-R), Skali Bólu Psychicznego, Skali Poczucia Sensu Życia (PIL) oraz testu przesiewowego nadużywania alkoholu (CAGE).
Wyniki Współczynnik α Cronbacha dla polskiej wersji C-SSRS wynosił 0,89. W analizie czynnikowej zidentyfikowano dwa czynniki latentne: (1) myśli, zamiary i plany samobójcze oraz (2) próby samobójcze w wywiadzie. Wystąpiły różnice w średnich wynikach wszystkich zastosowanych kwestionariuszy (mianowicie SBQ-R, Skali Bólu Psychicznego, CAGE, SIDAS, PIL i CESD-R) pomiędzy grupami ryzyka wg C-SSRS (p=0,01). Ryzyko samobójstwa wg C-SSRS miało związek z kategorią rozpoznania psychiatrycznego wg ICD-10 (p<0,001).
Wnioski
Polska wersja przesiewowej Skali Oceny Ryzyka Samobójstwa z Uniwersytetu Columbia (C-SSRS) jest narzędziem o dobrych właściwościach psychometrycznych. Może służyć do oceny ryzyka samobójstwa wśród pacjentów hospitalizowanych psychiatrycznie.
,
Objectives
To perform an adaptation and psychometric validation of the Polish version of the Columbia-Suicide Severity Rating Scale (C-SSRS) screen version in a clinical sample of patients admitted to the psychiatric hospital.
Methods
This was a single-center, observational and cross-sectional study. A total of 318 consecutive patients completed a set of questionnaires upon their admission to acute psychiatric units. The set comprised C-SSRS screener and the reference measures: the Suicidal Behaviors Questionnaire – Revised (SBQ-R), the Suicidal Ideation Attributes Scale (SIDAS), the Center of Epidemiological Studies Depression Scale – Revised (CESD-R), the Scale of Psychache, the Purpose in Life scale (PIL), and alcohol misuse screen test (CAGE).
Results Cronbach’s α of the C-SSRS was 0.89. Two latent components were identified in the factor analysis: (1) suicidal thoughts, intentions and plans, and (2) history of suicidal attempts. There were differences in the mean scores of all the utilized questionnaires (namely, SBQ-R, the Psychache scale, CAGE, SIDAS, PIL and CESD-R) between the C-SSRS risk groups (p=0.01). The C-SSRS risk group was associated with the category of the primary psychiatric diagnosis (p<0.001).
Conclusions
The Polish version of the Columbia-Suicide Severity Rating Scale screener is a questionnaire with good psychometric features to assess the suicidal risk among psychiatric in-patients. It can be used for the purposes of a routine assessment of suicidal risk among hospitalized patients.
Wójcik, Michał; Zmarzły, Nikola; Derkacz, Alicja; Kulpok-Bagiński, Tomasz; Blek, Natasza; Grabarek, Beniamin Oskar
In: Cell Cycle, vol. 23, no. 3, pp. 279–293, 2024, ISSN: 1538-4101, 1551-4005.
@article{wojcik_gene_2024,
title = {Gene expression profile of mitogen-activated kinases and microRNAs controlling their expression in HaCaT cell culture treated with lipopolysaccharide A and cyclosporine A},
author = {Michał Wójcik and Nikola Zmarzły and Alicja Derkacz and Tomasz Kulpok-Bagiński and Natasza Blek and Beniamin Oskar Grabarek},
url = {https://www.tandfonline.com/doi/full/10.1080/15384101.2024.2320508},
doi = {10.1080/15384101.2024.2320508},
issn = {1538-4101, 1551-4005},
year = {2024},
date = {2024-02-01},
urldate = {2024-10-28},
journal = {Cell Cycle},
volume = {23},
number = {3},
pages = {279–293},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Andruszko, Agata; Szydłowski, Jarosław; Grabarek, Beniamin Oskar; Mazur, Katarzyna; Sirek, Tomasz; Ossowski, Piotr; Kozikowski, Mieszko; Kaminiów, Konrad; Zybek-Kocik, Ariadna; Banaszewski, Jacek
Impact of Nutritional Status of Patients with Head and Neck Squamous Cell Carcinoma on the Expression Profile of Ghrelin, Irisin, and Titin Journal Article
In: Cancers, vol. 16, no. 2, pp. 437, 2024, ISSN: 2072-6694, (Publisher: MDPI AG).
@article{andruszko_impact_2024,
title = {Impact of Nutritional Status of Patients with Head and Neck Squamous Cell Carcinoma on the Expression Profile of Ghrelin, Irisin, and Titin},
author = {Agata Andruszko and Jarosław Szydłowski and Beniamin Oskar Grabarek and Katarzyna Mazur and Tomasz Sirek and Piotr Ossowski and Mieszko Kozikowski and Konrad Kaminiów and Ariadna Zybek-Kocik and Jacek Banaszewski},
url = {https://www.mdpi.com/2072-6694/16/2/437},
doi = {10.3390/cancers16020437},
issn = {2072-6694},
year = {2024},
date = {2024-01-01},
urldate = {2024-09-17},
journal = {Cancers},
volume = {16},
number = {2},
pages = {437},
abstract = {The goal of this paper was the evaluation of the changes in the expression profile of irisin, ghrelin, and titin in the carcinoma tissue and in the blood of patients with head and neck squamous cell carcinoma (HNSCC), including determining the profile of their expression in relation to patient nutrition. The study included 56 patients with diagnosed squamous cell carcinoma of HNSCC in the T3 and T4 stages of the disease. Healthy control tissue specimens were collected from an area 10 mm outside the histologically negative margin. In turn, the blood and serum from the control group came from healthy volunteers treated for non-oncologic reasons (n = 70). The molecular analysis allowed us to determine the profile of irisin, ghrelin, and titin methylation, evaluate their expression on the level of mRNA (quantitative Reverse Transcription Polymerase Chain Reaction; qRT-PCR) and protein (Enzyme-Linked Immunosorbent Assay Reaction; ELISA) in the carcinoma tissue and the margin of healthy tissue, as well as in serum of patients in the study and control groups. At the start of our observations, a Body Mass Index (BMI) < 18.5 was noted in 42 of the patients, while six months after the treatment a BMI < 18.5 was noted in 29 patients. We also noted a decrease in the expression of irisin, ghrelin, and titin both on the level of mRNA and protein, as well as a potential regulation of their expression via DNA methylation. There is no convincing evidence that the proteins assayed in the present work are specific with regard to HNSSC.},
note = {Publisher: MDPI AG},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
The goal of this paper was the evaluation of the changes in the expression profile of irisin, ghrelin, and titin in the carcinoma tissue and in the blood of patients with head and neck squamous cell carcinoma (HNSCC), including determining the profile of their expression in relation to patient nutrition. The study included 56 patients with diagnosed squamous cell carcinoma of HNSCC in the T3 and T4 stages of the disease. Healthy control tissue specimens were collected from an area 10 mm outside the histologically negative margin. In turn, the blood and serum from the control group came from healthy volunteers treated for non-oncologic reasons (n = 70). The molecular analysis allowed us to determine the profile of irisin, ghrelin, and titin methylation, evaluate their expression on the level of mRNA (quantitative Reverse Transcription Polymerase Chain Reaction; qRT-PCR) and protein (Enzyme-Linked Immunosorbent Assay Reaction; ELISA) in the carcinoma tissue and the margin of healthy tissue, as well as in serum of patients in the study and control groups. At the start of our observations, a Body Mass Index (BMI) < 18.5 was noted in 42 of the patients, while six months after the treatment a BMI < 18.5 was noted in 29 patients. We also noted a decrease in the expression of irisin, ghrelin, and titin both on the level of mRNA and protein, as well as a potential regulation of their expression via DNA methylation. There is no convincing evidence that the proteins assayed in the present work are specific with regard to HNSSC.
The presence of cribriform pattern in prostate biopsy and radical prostatectomy is associated with negative postoperative pathological features Journal Article
In: Central European Journal of Urology, 2024, ISSN: 2080-4873, (Publisher: Polish Urological Association).
@article{noauthor_presence_2024,
title = {The presence of cribriform pattern in prostate biopsy and radical prostatectomy is associated with negative postoperative pathological features},
url = {https://ceju.online/journal/2023/cribriform-pattern-prostate-cancer-radical-prostatectomy-2315.php},
doi = {10.5173/ceju.2023.215},
issn = {2080-4873},
year = {2024},
date = {2024-01-01},
urldate = {2024-09-17},
journal = {Central European Journal of Urology},
note = {Publisher: Polish Urological Association},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Krawczyk, Artur; Kurek, Krzysztof; Nucera, Gabriella; Pruc, Michal; Swieczkowski, Damian; Kacprzyk, Dawid; Skrzypek, Ewa; Bragazzi, Nicola Luigi; Safiejko, Kamil; Szarpak, Lukasz
Effect of COVID-19 on the prevalence of bystanders performing cardiopulmonary resuscitation: A systematic review and meta-analysis Journal Article
In: Cardiology Journal, 2024, ISSN: 1898-018X, 1897-5593, (Publisher: VM Media Group sp. z o.o).
@article{krawczyk_effect_2024,
title = {Effect of COVID-19 on the prevalence of bystanders performing cardiopulmonary resuscitation: A systematic review and meta-analysis},
author = {Artur Krawczyk and Krzysztof Kurek and Gabriella Nucera and Michal Pruc and Damian Swieczkowski and Dawid Kacprzyk and Ewa Skrzypek and Nicola Luigi Bragazzi and Kamil Safiejko and Lukasz Szarpak},
url = {https://journals.viamedica.pl/cardiology_journal/article/view/98616},
doi = {10.5603/cj.98616},
issn = {1898-018X, 1897-5593},
year = {2024},
date = {2024-01-01},
urldate = {2024-09-17},
journal = {Cardiology Journal},
note = {Publisher: VM Media Group sp. z o.o},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Talarska, Patrycja; Błaszkiewicz, Paulina; Kostrzewa, Artur; Wirstlein, Przemysław; Cegłowski, Michał; Nowaczyk, Grzegorz; Dudkowiak, Alina; Grabarek, Beniamin Oskar; Głowacka-Stalmach, Paulina; Szarpak, Agnieszka; Żurawski, Jakub
Effects of Spherical and Rod-like Gold Nanoparticles on the Reactivity of Human Peripheral Blood Leukocytes Journal Article
In: Antioxidants, vol. 13, no. 2, pp. 157, 2024, ISSN: 2076-3921, (Publisher: MDPI AG).
@article{talarska_effects_2024,
title = {Effects of Spherical and Rod-like Gold Nanoparticles on the Reactivity of Human Peripheral Blood Leukocytes},
author = {Patrycja Talarska and Paulina Błaszkiewicz and Artur Kostrzewa and Przemysław Wirstlein and Michał Cegłowski and Grzegorz Nowaczyk and Alina Dudkowiak and Beniamin Oskar Grabarek and Paulina Głowacka-Stalmach and Agnieszka Szarpak and Jakub Żurawski},
url = {https://www.mdpi.com/2076-3921/13/2/157},
doi = {10.3390/antiox13020157},
issn = {2076-3921},
year = {2024},
date = {2024-01-01},
urldate = {2024-09-17},
journal = {Antioxidants},
volume = {13},
number = {2},
pages = {157},
abstract = {Gold nanoparticles (GNPs) are widely used in the technological and biomedical industries, which is a major driver of research on these nanoparticles. The main goal of this study was to determine the influence of GNPs (at 20, 100, and 200 μg/mL concentrations) on the reactivity of human peripheral blood leukocytes. Flow cytometry was used to evaluate the respiratory burst activity and pyroptosis in monocytes and granulocytes following incubation with GNPs for 30 and 60 min. Furthermore, the concentration of interleukin-1β (IL-1β) in human blood samples was assessed using enzyme-linked immunosorbent assay (ELISA) after their incubation with GNPs for 24 h. Under the conditions tested in the study, the GNPs did not significantly affect the production of reactive oxygen species in the granulocytes and monocytes that were not stimulated using phorbol 12-myristate 13-acetate (PMA) in comparison to the samples exposed to PMA (p < 0.05). Compared to the control sample, the greatest significant increase in the mean fluorescence intensity of the granulocytes occurred in the samples incubated with CGNPs = 100 and 200 µg/mL for tinc = 30 and 60 min (p < 0.05). From our results, we conclude that the physicochemical properties of the nanoparticles, chemical composition, and the type of nanoparticles used in the unit, along with the unit and incubation time, influence the induced toxicity.},
note = {Publisher: MDPI AG},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Gold nanoparticles (GNPs) are widely used in the technological and biomedical industries, which is a major driver of research on these nanoparticles. The main goal of this study was to determine the influence of GNPs (at 20, 100, and 200 μg/mL concentrations) on the reactivity of human peripheral blood leukocytes. Flow cytometry was used to evaluate the respiratory burst activity and pyroptosis in monocytes and granulocytes following incubation with GNPs for 30 and 60 min. Furthermore, the concentration of interleukin-1β (IL-1β) in human blood samples was assessed using enzyme-linked immunosorbent assay (ELISA) after their incubation with GNPs for 24 h. Under the conditions tested in the study, the GNPs did not significantly affect the production of reactive oxygen species in the granulocytes and monocytes that were not stimulated using phorbol 12-myristate 13-acetate (PMA) in comparison to the samples exposed to PMA (p < 0.05). Compared to the control sample, the greatest significant increase in the mean fluorescence intensity of the granulocytes occurred in the samples incubated with CGNPs = 100 and 200 µg/mL for tinc = 30 and 60 min (p < 0.05). From our results, we conclude that the physicochemical properties of the nanoparticles, chemical composition, and the type of nanoparticles used in the unit, along with the unit and incubation time, influence the induced toxicity.
Klingemann, Justyna; Mokros, Łukasz; Sienkiewicz-Jarosz, Halina; Świtaj, Piotr
The prevalence of occupational burnout and its individual and situational predictors among addiction therapists Journal Article
In: Alcohol and Alcoholism, vol. 59, no. 1, 2024, ISSN: 0735-0414, 1464-3502, (Publisher: Oxford University Press (OUP)).
@article{klingemann_prevalence_2024,
title = {The prevalence of occupational burnout and its individual and situational predictors among addiction therapists},
author = {Justyna Klingemann and Łukasz Mokros and Halina Sienkiewicz-Jarosz and Piotr Świtaj},
url = {https://academic.oup.com/alcalc/article/doi/10.1093/alcalc/agad074/7416981},
doi = {10.1093/alcalc/agad074},
issn = {0735-0414, 1464-3502},
year = {2024},
date = {2024-01-01},
urldate = {2024-09-17},
journal = {Alcohol and Alcoholism},
volume = {59},
number = {1},
abstract = {Abstract This study assesses the prevalence and individual and organizational predictors of occupational burnout among addiction therapists. A total of 452 addiction therapists from a representative sample of 184 Polish alcohol treatment facilities (outpatient and inpatient) participated in the study (facility response rate = 42%). The Oldenburg Burnout Inventory was used to measure occupational burnout, and 15 subscales of the Copenhagen Psychosocial Questionnaire II were administered to assess psychosocial work conditions. In addition, the Coronavirus Anxiety Scale, the Hospital Anxiety and Depression Scale and the abbreviated six-item De Jong Gierveld Loneliness Scale measured other important dimensions of addiction therapists' psychosocial functioning. Logistic regression was used for the analysis of the data. Occupational burnout was noticeably prevalent in the study group: 62% of respondents experienced exhaustion and 50% experienced disengagement from work, both to at least a moderate degree. Situational (organizational) variables were the most important predictors, explaining much more of the variance in both dimensions of burnout than the individual factors, of which only depression was significantly related to higher levels of exhaustion. Coronavirus anxiety played a marginal role in explaining the severity of burnout. The current study is one of the first attempts to assess the level of occupational burnout among addiction therapists and to comprehensively investigate the factors contributing to it. The findings provide useful information for the development of interventions aimed at preventing or reducing burnout in this professional group.},
note = {Publisher: Oxford University Press (OUP)},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Abstract This study assesses the prevalence and individual and organizational predictors of occupational burnout among addiction therapists. A total of 452 addiction therapists from a representative sample of 184 Polish alcohol treatment facilities (outpatient and inpatient) participated in the study (facility response rate = 42%). The Oldenburg Burnout Inventory was used to measure occupational burnout, and 15 subscales of the Copenhagen Psychosocial Questionnaire II were administered to assess psychosocial work conditions. In addition, the Coronavirus Anxiety Scale, the Hospital Anxiety and Depression Scale and the abbreviated six-item De Jong Gierveld Loneliness Scale measured other important dimensions of addiction therapists' psychosocial functioning. Logistic regression was used for the analysis of the data. Occupational burnout was noticeably prevalent in the study group: 62% of respondents experienced exhaustion and 50% experienced disengagement from work, both to at least a moderate degree. Situational (organizational) variables were the most important predictors, explaining much more of the variance in both dimensions of burnout than the individual factors, of which only depression was significantly related to higher levels of exhaustion. Coronavirus anxiety played a marginal role in explaining the severity of burnout. The current study is one of the first attempts to assess the level of occupational burnout among addiction therapists and to comprehensively investigate the factors contributing to it. The findings provide useful information for the development of interventions aimed at preventing or reducing burnout in this professional group.
Serafin, Pawel; Szeleszczuk, Łukasz; Zhukov, Igor; Szűcs, Edina; Gombos, Dávid; Stefanucci, Azzurra; Mollica, Adriano; Pisklak, Dariusz Maciej; Kleczkowska, Patrycja
Opioid/Dopamine Receptor Binding Studies, NMR and Molecular Dynamics Simulation of LENART01 Chimera, an Opioid-Bombesin-like Peptide Journal Article
In: Molecules, vol. 29, no. 1, pp. 272, 2024, ISSN: 1420-3049, (Publisher: MDPI AG).
@article{serafin_opioiddopamine_2024,
title = {Opioid/Dopamine Receptor Binding Studies, NMR and Molecular Dynamics Simulation of LENART01 Chimera, an Opioid-Bombesin-like Peptide},
author = {Pawel Serafin and Łukasz Szeleszczuk and Igor Zhukov and Edina Szűcs and Dávid Gombos and Azzurra Stefanucci and Adriano Mollica and Dariusz Maciej Pisklak and Patrycja Kleczkowska},
url = {https://www.mdpi.com/1420-3049/29/1/272},
doi = {10.3390/molecules29010272},
issn = {1420-3049},
year = {2024},
date = {2024-01-01},
urldate = {2024-09-17},
journal = {Molecules},
volume = {29},
number = {1},
pages = {272},
abstract = {The design and development of hybrid compounds as a new class of drug candidates remains an excellent opportunity to improve the pharmacological properties of drugs (including enzymatic stability, efficacy and pharmacokinetic and pharmacodynamic profiles). In addition, considering various complex diseases and/or disorders, the conjugate chemistry approach is highly acceptable and justified. Opioids have long been recognized as the most potent analgesics and serve as the basic pharmacophore for potent hybrid compounds that may be useful in pain management. However, a risk of tolerance and physical dependence exists. Since dopamine receptors have been implicated in the aforementioned adverse effects of opioids, the construction of a hybrid with dual action at opioid and dopamine receptors is of interest. Herein, we present nuclear magnetic resonance (NMR) spectroscopy and molecular dynamics simulation results for LENART01, an opioid–ranatensin hybrid peptide. Apart from molecular docking, protein–ligand interactions were also assessed in vitro using a receptor binding assay, which proved LENART01 to be bound to mu-opioid and dopamine receptors, respectively.},
note = {Publisher: MDPI AG},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
The design and development of hybrid compounds as a new class of drug candidates remains an excellent opportunity to improve the pharmacological properties of drugs (including enzymatic stability, efficacy and pharmacokinetic and pharmacodynamic profiles). In addition, considering various complex diseases and/or disorders, the conjugate chemistry approach is highly acceptable and justified. Opioids have long been recognized as the most potent analgesics and serve as the basic pharmacophore for potent hybrid compounds that may be useful in pain management. However, a risk of tolerance and physical dependence exists. Since dopamine receptors have been implicated in the aforementioned adverse effects of opioids, the construction of a hybrid with dual action at opioid and dopamine receptors is of interest. Herein, we present nuclear magnetic resonance (NMR) spectroscopy and molecular dynamics simulation results for LENART01, an opioid–ranatensin hybrid peptide. Apart from molecular docking, protein–ligand interactions were also assessed in vitro using a receptor binding assay, which proved LENART01 to be bound to mu-opioid and dopamine receptors, respectively.
Urbanowicz, Tomasz K.; Michalak, Michał; Olasińska-Wiśniewska, Anna; Żukowski, Marcel; Koczorowski, Kamil; Łasowski, Bartosz; Woźnicki, Michał; Filipiak, Krzysztof J.; Tykarski, Andrzej; Jemielity, Marek
Left main coronary artery disease treated with beating heart surgery: 10-year single center results Journal Article
In: Advances in Interventional Cardiology, vol. 20, no. 2, pp. 157–163, 2024, ISSN: 1734-9338.
@article{urbanowicz_left_2024,
title = {Left main coronary artery disease treated with beating heart surgery: 10-year single center results},
author = {Tomasz K. Urbanowicz and Michał Michalak and Anna Olasińska-Wiśniewska and Marcel Żukowski and Kamil Koczorowski and Bartosz Łasowski and Michał Woźnicki and Krzysztof J. Filipiak and Andrzej Tykarski and Marek Jemielity},
url = {https://www.termedia.pl/doi/10.5114/aic.2024.140319},
doi = {10.5114/aic.2024.140319},
issn = {1734-9338},
year = {2024},
date = {2024-01-01},
urldate = {2024-10-28},
journal = {Advances in Interventional Cardiology},
volume = {20},
number = {2},
pages = {157–163},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Serafin, Pawel; Szeleszczuk, Łukasz; Zhukov, Igor; Szűcs, Edina; Gombos, Dávid; Stefanucci, Azzurra; Mollica, Adriano; Pisklak, Dariusz Maciej; Kleczkowska, Patrycja
Opioid/Dopamine Receptor Binding Studies, NMR and Molecular Dynamics Simulation of LENART01 Chimera, an Opioid-Bombesin-like Peptide Journal Article
In: Molecules, vol. 29, no. 1, pp. 272, 2024, ISSN: 1420-3049.
@article{serafin_opioiddopamine_2024b,
title = {Opioid/Dopamine Receptor Binding Studies, NMR and Molecular Dynamics Simulation of LENART01 Chimera, an Opioid-Bombesin-like Peptide},
author = {Pawel Serafin and Łukasz Szeleszczuk and Igor Zhukov and Edina Szűcs and Dávid Gombos and Azzurra Stefanucci and Adriano Mollica and Dariusz Maciej Pisklak and Patrycja Kleczkowska},
url = {https://www.mdpi.com/1420-3049/29/1/272},
doi = {10.3390/molecules29010272},
issn = {1420-3049},
year = {2024},
date = {2024-01-01},
urldate = {2025-03-14},
journal = {Molecules},
volume = {29},
number = {1},
pages = {272},
abstract = {The design and development of hybrid compounds as a new class of drug candidates remains an excellent opportunity to improve the pharmacological properties of drugs (including enzymatic stability, efficacy and pharmacokinetic and pharmacodynamic profiles). In addition, considering various complex diseases and/or disorders, the conjugate chemistry approach is highly acceptable and justified. Opioids have long been recognized as the most potent analgesics and serve as the basic pharmacophore for potent hybrid compounds that may be useful in pain management. However, a risk of tolerance and physical dependence exists. Since dopamine receptors have been implicated in the aforementioned adverse effects of opioids, the construction of a hybrid with dual action at opioid and dopamine receptors is of interest. Herein, we present nuclear magnetic resonance (NMR) spectroscopy and molecular dynamics simulation results for LENART01, an opioid–ranatensin hybrid peptide. Apart from molecular docking, protein–ligand interactions were also assessed in vitro using a receptor binding assay, which proved LENART01 to be bound to mu-opioid and dopamine receptors, respectively.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
The design and development of hybrid compounds as a new class of drug candidates remains an excellent opportunity to improve the pharmacological properties of drugs (including enzymatic stability, efficacy and pharmacokinetic and pharmacodynamic profiles). In addition, considering various complex diseases and/or disorders, the conjugate chemistry approach is highly acceptable and justified. Opioids have long been recognized as the most potent analgesics and serve as the basic pharmacophore for potent hybrid compounds that may be useful in pain management. However, a risk of tolerance and physical dependence exists. Since dopamine receptors have been implicated in the aforementioned adverse effects of opioids, the construction of a hybrid with dual action at opioid and dopamine receptors is of interest. Herein, we present nuclear magnetic resonance (NMR) spectroscopy and molecular dynamics simulation results for LENART01, an opioid–ranatensin hybrid peptide. Apart from molecular docking, protein–ligand interactions were also assessed in vitro using a receptor binding assay, which proved LENART01 to be bound to mu-opioid and dopamine receptors, respectively.
2023
Koleżyńska, Barbara; Solarz, Krzysztof; Wieczorek, Weronika; Sagan, Dorota; Boroń, Dariusz; Staszkiewicz, Rafał; Sobański, Dawid; Sirek, Tomasz; Janik, Anna; Łojko, Piotr; Grabarek, Beniamin Oskar
High Prevalence of Borrelia burgdorferi Antibodies in Jaworzno, Poland: A Retrospective Study Revealing Endemic Lyme Borreliosis Journal Article
In: Medical Science Monitor, vol. 30, 2023, ISSN: 1643-3750, (Publisher: International Scientific Information, Inc.).
@article{kolezynska_high_2023,
title = {High Prevalence of Borrelia burgdorferi Antibodies in Jaworzno, Poland: A Retrospective Study Revealing Endemic Lyme Borreliosis},
author = {Barbara Koleżyńska and Krzysztof Solarz and Weronika Wieczorek and Dorota Sagan and Dariusz Boroń and Rafał Staszkiewicz and Dawid Sobański and Tomasz Sirek and Anna Janik and Piotr Łojko and Beniamin Oskar Grabarek},
url = {https://www.medscimonit.com/abstract/index/idArt/943203},
doi = {10.12659/msm.943203},
issn = {1643-3750},
year = {2023},
date = {2023-12-01},
urldate = {2024-09-17},
journal = {Medical Science Monitor},
volume = {30},
note = {Publisher: International Scientific Information, Inc.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Uliński, Robert; Dąbrowska, Marta; Domagała-Kulawik, Joanna
Lung cancer in the course of chronic obstructive pulmonary disease – the clinical picture in light of current diagnostic recommendations Journal Article
In: Nowotwory. Journal of Oncology, vol. 73, no. 6, pp. 325–337, 2023, ISSN: 2300-2115, 0029-540X, (Publisher: VM Media Group sp. z o.o).
@article{ulinski_lung_2023,
title = {Lung cancer in the course of chronic obstructive pulmonary disease – the clinical picture in light of current diagnostic recommendations},
author = {Robert Uliński and Marta Dąbrowska and Joanna Domagała-Kulawik},
url = {https://journals.viamedica.pl/nowotwory_journal_of_oncology/article/view/97112},
doi = {10.5603/njo.97112},
issn = {2300-2115, 0029-540X},
year = {2023},
date = {2023-12-01},
urldate = {2024-09-17},
journal = {Nowotwory. Journal of Oncology},
volume = {73},
number = {6},
pages = {325–337},
note = {Publisher: VM Media Group sp. z o.o},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Bragazzi, Nicola Luigi; Buchinger, Michele; Szarpak, Lukasz; Chmielewski, Jaroslaw; Goździewska, Małgorzata; Gotlib, Joanna; Farah, Rola Elias
Knowledge, attitudes, and practices towards COVID-19 and COVID-19 vaccines among Obstetrician-Gynaecologists Journal Article
In: Annals of Agricultural and Environmental Medicine, vol. 30, no. 4, pp. 669–676, 2023, ISSN: 1232-1966, 1898-2263, (Publisher: Institute of Rural Health).
@article{bragazzi_knowledge_2023,
title = {Knowledge, attitudes, and practices towards COVID-19 and COVID-19 vaccines among Obstetrician-Gynaecologists},
author = {Nicola Luigi Bragazzi and Michele Buchinger and Lukasz Szarpak and Jaroslaw Chmielewski and Małgorzata Goździewska and Joanna Gotlib and Rola Elias Farah},
url = {https://www.aaem.pl/Knowledge-attitudes-and-practices-towards-COVID-19-and-COVID-19-vaccines-among-Obstetrician,176959,0,2.html},
doi = {10.26444/aaem/176959},
issn = {1232-1966, 1898-2263},
year = {2023},
date = {2023-12-01},
urldate = {2024-09-17},
journal = {Annals of Agricultural and Environmental Medicine},
volume = {30},
number = {4},
pages = {669–676},
note = {Publisher: Institute of Rural Health},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Lewicki, Sławomir; Zwoliński, Michał; Hovagimyan, Adrian; Stelmasiak, Marta; Szarpak, Łukasz; Lewicka, Aneta; Pojda, Zygmunt; Szymański, Łukasz
Chitosan-Based Dressing as a Sustained Delivery System for Bioactive Cytokines Journal Article
In: International Journal of Molecular Sciences, vol. 25, no. 1, pp. 30, 2023, ISSN: 1422-0067, (Publisher: MDPI AG).
@article{lewicki_chitosan-based_2023,
title = {Chitosan-Based Dressing as a Sustained Delivery System for Bioactive Cytokines},
author = {Sławomir Lewicki and Michał Zwoliński and Adrian Hovagimyan and Marta Stelmasiak and Łukasz Szarpak and Aneta Lewicka and Zygmunt Pojda and Łukasz Szymański},
url = {https://www.mdpi.com/1422-0067/25/1/30},
doi = {10.3390/ijms25010030},
issn = {1422-0067},
year = {2023},
date = {2023-12-01},
urldate = {2024-09-17},
journal = {International Journal of Molecular Sciences},
volume = {25},
number = {1},
pages = {30},
abstract = {Wounds represent a common occurrence in human life. Consequently, scientific investigations are underway to advance wound healing methodologies, with a notable focus on dressings imbued with biologically active compounds capable of orchestrating the wound microenvironment through meticulously regulated release mechanisms. Among these bioactive agents are cytokines, which, when administered to the wound milieu without appropriate protection, undergo rapid loss of their functional attributes. Within the context of this research, we present a method for fabricating dressings enriched with G-CSF (granulocyte colony-stimulating factor) or GM-CSF (granulocyte-macrophage colony-stimulating factor), showcasing both biological activity and protracted release dynamics. Based on Ligasano, a commercial polyurethane foam dressing, and chitosan crosslinked with TPP (sodium tripolyphosphate), these dressings are noncytotoxic and enable cytokine incorporation. The recovery of cytokines from dressings varied based on the dressing preparation and storage techniques (without modification, drying, freeze-drying followed by storage at 4 °C or freeze-drying followed by storage at 24 °C) and cytokine type. Generally, drying reduced cytokine levels and their bioactivity, especially with G-CSF. The recovery of G-CSF from unmodified dressings was lower compared to GM-CSF (60% vs. 80%). In summary, our freeze-drying approach enables the storage of G-CSF or GM-CSF enriched dressings at 24 °C with minimal cytokine loss, preserving their biological activity and thus enhancing future clinical availability.},
note = {Publisher: MDPI AG},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Wounds represent a common occurrence in human life. Consequently, scientific investigations are underway to advance wound healing methodologies, with a notable focus on dressings imbued with biologically active compounds capable of orchestrating the wound microenvironment through meticulously regulated release mechanisms. Among these bioactive agents are cytokines, which, when administered to the wound milieu without appropriate protection, undergo rapid loss of their functional attributes. Within the context of this research, we present a method for fabricating dressings enriched with G-CSF (granulocyte colony-stimulating factor) or GM-CSF (granulocyte-macrophage colony-stimulating factor), showcasing both biological activity and protracted release dynamics. Based on Ligasano, a commercial polyurethane foam dressing, and chitosan crosslinked with TPP (sodium tripolyphosphate), these dressings are noncytotoxic and enable cytokine incorporation. The recovery of cytokines from dressings varied based on the dressing preparation and storage techniques (without modification, drying, freeze-drying followed by storage at 4 °C or freeze-drying followed by storage at 24 °C) and cytokine type. Generally, drying reduced cytokine levels and their bioactivity, especially with G-CSF. The recovery of G-CSF from unmodified dressings was lower compared to GM-CSF (60% vs. 80%). In summary, our freeze-drying approach enables the storage of G-CSF or GM-CSF enriched dressings at 24 °C with minimal cytokine loss, preserving their biological activity and thus enhancing future clinical availability.
Strózik, Mateusz; Wiciak, Hanna; Szarpak, Lukasz; Wroblewski, Pawel; Smereka, Jacek
EMS Interventions during Planned Out-of-Hospital Births with a Midwife: A Retrospective Analysis over Four Years in the Polish Population Journal Article
In: Journal of Clinical Medicine, vol. 12, no. 24, pp. 7719, 2023, ISSN: 2077-0383, (Publisher: MDPI AG).
@article{strozik_ems_2023,
title = {EMS Interventions during Planned Out-of-Hospital Births with a Midwife: A Retrospective Analysis over Four Years in the Polish Population},
author = {Mateusz Strózik and Hanna Wiciak and Lukasz Szarpak and Pawel Wroblewski and Jacek Smereka},
url = {https://www.mdpi.com/2077-0383/12/24/7719},
doi = {10.3390/jcm12247719},
issn = {2077-0383},
year = {2023},
date = {2023-12-01},
urldate = {2024-09-17},
journal = {Journal of Clinical Medicine},
volume = {12},
number = {24},
pages = {7719},
abstract = {Planned out-of-hospital births, facilitated by highly skilled and experienced midwives, offer expectant parents a distinct opportunity to partake in a personalized, intimate, and empowering birth experience. Many parents opt for the care provided by midwives who specialize in supporting home births. This retrospective study is based on 41,335 EMS emergency calls to women in advanced pregnancy, of which 209 concerned home birth situations documenting obstetrical emergencies over four years (January 2018 to December 2022), of which 60 involved the assistance of a midwife. Data were obtained from the Polish Central System for Emergency Medical Services Missions Monitoring, encompassing all EMS interventions in pregnant women. The most frequent reason for emergency calls for obstetrical emergencies with the assistance of a midwife was a failure to separate the placenta or incomplete afterbirth (18 cases; 30%), followed by perinatal haemorrhage (12 cases; 20%) and deterioration of the newborn’s condition (8 cases; 13%). Paramedic-staffed EMS teams conducted most interventions (43 cases; 72%), with only 17 (28%) involving the presence of a physician. Paramedics with extensive medical training and the ability to provide emergency care are in a unique position that allows them to play a pivotal role in supporting planned out-of-hospital births. The analysed data from 2018–2022 show that EMS deliveries in Poland are infrequent and typically uncomplicated. Continuing education, training, and adequate funding are required to ensure the EMS is ready to provide the best care. EMS medical records forms should be adapted to the specific aspects of care for pregnant patients and newborns.},
note = {Publisher: MDPI AG},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Planned out-of-hospital births, facilitated by highly skilled and experienced midwives, offer expectant parents a distinct opportunity to partake in a personalized, intimate, and empowering birth experience. Many parents opt for the care provided by midwives who specialize in supporting home births. This retrospective study is based on 41,335 EMS emergency calls to women in advanced pregnancy, of which 209 concerned home birth situations documenting obstetrical emergencies over four years (January 2018 to December 2022), of which 60 involved the assistance of a midwife. Data were obtained from the Polish Central System for Emergency Medical Services Missions Monitoring, encompassing all EMS interventions in pregnant women. The most frequent reason for emergency calls for obstetrical emergencies with the assistance of a midwife was a failure to separate the placenta or incomplete afterbirth (18 cases; 30%), followed by perinatal haemorrhage (12 cases; 20%) and deterioration of the newborn’s condition (8 cases; 13%). Paramedic-staffed EMS teams conducted most interventions (43 cases; 72%), with only 17 (28%) involving the presence of a physician. Paramedics with extensive medical training and the ability to provide emergency care are in a unique position that allows them to play a pivotal role in supporting planned out-of-hospital births. The analysed data from 2018–2022 show that EMS deliveries in Poland are infrequent and typically uncomplicated. Continuing education, training, and adequate funding are required to ensure the EMS is ready to provide the best care. EMS medical records forms should be adapted to the specific aspects of care for pregnant patients and newborns.
Kurek, Krzysztof; Swieczkowski, Damian; Pruc, Michal; Tomaszewska, Monika; Cubala, Wieslaw Jerzy; Szarpak, Lukasz
In: Journal of Clinical Medicine, vol. 12, no. 24, pp. 7655, 2023, ISSN: 2077-0383, (Publisher: MDPI AG).
@article{kurek_predictive_2023,
title = {Predictive Performance of Neuron-Specific Enolase (NSE) for Survival after Resuscitation from Cardiac Arrest: A Systematic Review and Meta-Analysis},
author = {Krzysztof Kurek and Damian Swieczkowski and Michal Pruc and Monika Tomaszewska and Wieslaw Jerzy Cubala and Lukasz Szarpak},
url = {https://www.mdpi.com/2077-0383/12/24/7655},
doi = {10.3390/jcm12247655},
issn = {2077-0383},
year = {2023},
date = {2023-12-01},
urldate = {2024-09-17},
journal = {Journal of Clinical Medicine},
volume = {12},
number = {24},
pages = {7655},
abstract = {The prediction of outcomes following cardiac arrest continues to provide significant difficulties. A preferred strategy involves adopting a multimodal approach, which encompasses the careful evaluation of the biomarker neuron-specific enolase (NSE). This systematic review and meta-analysis aimed to gather and summarize new and existing evidence on the prediction effect of neuron-specific enolase for survival to hospital discharge among adult patients with cardiac arrest. We searched PubMed Central, Scopus, EMBASE databases, and the Cochrane Library without language restrictions from their inceptions until 30 October 2023 and checked the reference lists of the included studies. Pooled results were reported as standardized mean differences (SMDs) and were presented with corresponding 95% confidence intervals (CIs). The primary outcome was survival to hospital discharge (SHD). Eighty-six articles with 10,845 participants were included. NSE showed a notable degree of specificity in its ability to predict mortality as well as neurological status among individuals who experienced cardiac arrest (p < 0.05). This study demonstrates the ability to predict fatality rates and neurological outcomes, both during the time of admission and at various time intervals after cardiac arrest. The use of NSE in a multimodal neuroprognostication algorithm has promise in improving the accuracy of prognoses for persons who have undergone cardiac arrest.},
note = {Publisher: MDPI AG},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
The prediction of outcomes following cardiac arrest continues to provide significant difficulties. A preferred strategy involves adopting a multimodal approach, which encompasses the careful evaluation of the biomarker neuron-specific enolase (NSE). This systematic review and meta-analysis aimed to gather and summarize new and existing evidence on the prediction effect of neuron-specific enolase for survival to hospital discharge among adult patients with cardiac arrest. We searched PubMed Central, Scopus, EMBASE databases, and the Cochrane Library without language restrictions from their inceptions until 30 October 2023 and checked the reference lists of the included studies. Pooled results were reported as standardized mean differences (SMDs) and were presented with corresponding 95% confidence intervals (CIs). The primary outcome was survival to hospital discharge (SHD). Eighty-six articles with 10,845 participants were included. NSE showed a notable degree of specificity in its ability to predict mortality as well as neurological status among individuals who experienced cardiac arrest (p < 0.05). This study demonstrates the ability to predict fatality rates and neurological outcomes, both during the time of admission and at various time intervals after cardiac arrest. The use of NSE in a multimodal neuroprognostication algorithm has promise in improving the accuracy of prognoses for persons who have undergone cardiac arrest.
Fialek, Bartosz; Roquetaillade, Charles De; Pruc, Michal; Navolokina, Alla; Chirico, Francesco; Ladny, Jerzy Robert; Peacock, Frank William; Szarpak, Lukasz
Systematic review with meta-analysis of mid-regional pro-adrenomedullin (MR-proadm) as a prognostic marker in Covid-19-hospitalized patients Journal Article
In: Annals of Medicine, vol. 55, no. 1, pp. 379–387, 2023, ISSN: 0785-3890, 1365-2060, (Publisher: Informa UK Limited).
@article{fialek_systematic_2023,
title = {Systematic review with meta-analysis of mid-regional pro-adrenomedullin (MR-proadm) as a prognostic marker in Covid-19-hospitalized patients},
author = {Bartosz Fialek and Charles De Roquetaillade and Michal Pruc and Alla Navolokina and Francesco Chirico and Jerzy Robert Ladny and Frank William Peacock and Lukasz Szarpak},
url = {https://www.tandfonline.com/doi/full/10.1080/07853890.2022.2162116},
doi = {10.1080/07853890.2022.2162116},
issn = {0785-3890, 1365-2060},
year = {2023},
date = {2023-12-01},
urldate = {2024-09-17},
journal = {Annals of Medicine},
volume = {55},
number = {1},
pages = {379–387},
note = {Publisher: Informa UK Limited},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Urbanowicz, Tomasz; Hanć, Anetta; Olasińska-Wiśniewska, Anna; Komosa, Anna; Filipiak, Krzysztof J.; Radziemski, Artur; Matejuk, Mateusz; Uruski, Paweł; Tykarski, Andrzej; Jemielity, Marek
In: Reviews in Cardiovascular Medicine, vol. 24, no. 12, pp. 358, 2023, ISSN: 1530-6550.
@article{urbanowicz_relation_2023,
title = {Relation between Systemic Inflammatory Index (SII) and Hair Trace Elements, Metals and Metalloids Concentration in Epicardial Coronary Artery Disease—Preliminary Report},
author = {Tomasz Urbanowicz and Anetta Hanć and Anna Olasińska-Wiśniewska and Anna Komosa and Krzysztof J. Filipiak and Artur Radziemski and Mateusz Matejuk and Paweł Uruski and Andrzej Tykarski and Marek Jemielity},
url = {https://www.imrpress.com/journal/RCM/24/12/10.31083/j.rcm2412358},
doi = {10.31083/j.rcm2412358},
issn = {1530-6550},
year = {2023},
date = {2023-12-01},
urldate = {2024-10-28},
journal = {Reviews in Cardiovascular Medicine},
volume = {24},
number = {12},
pages = {358},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Urbanowicz, Tomasz; Olasińska-Wiśniewska, Anna; Michalak, Michał; Komosa, Anna; Filipiak, Krzysztof J.; Uruski, Paweł; Radziemski, Artur; Tykarski, Andrzej; Jemielity, Marek
Predictive role of monocyte count for significant coronary artery disease identification in patients with stable coronary artery disease Journal Article
In: Cardiology Journal, pp. VM/OJS/J/95131, 2023, ISSN: 1898-018X, 1897-5593.
@article{urbanowicz_predictive_2023,
title = {Predictive role of monocyte count for significant coronary artery disease identification in patients with stable coronary artery disease},
author = {Tomasz Urbanowicz and Anna Olasińska-Wiśniewska and Michał Michalak and Anna Komosa and Krzysztof J. Filipiak and Paweł Uruski and Artur Radziemski and Andrzej Tykarski and Marek Jemielity},
url = {https://journals.viamedica.pl/cardiology_journal/article/view/95131},
doi = {10.5603/cj.95131},
issn = {1898-018X, 1897-5593},
year = {2023},
date = {2023-12-01},
urldate = {2024-10-28},
journal = {Cardiology Journal},
pages = {VM/OJS/J/95131},
keywords = {},
pubstate = {published},
tppubtype = {article}
}